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Primary immunodeficiencies (severe)

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Search Period All yearsLast 12 monthsLast 5 years Topic All topicsGeneralNutrition and dietAlternative treatment methods Type of research Any type of researchHighest evidence only (82)Meta-analysis (18)Treatment guideline (8)Randomized Research (24)Phase 3 study (20)Systematic review (12)Clinical trial (662)Review article (238)Early study (phase 1 or 2) (8)Description of some patients (291)Laboratory or animal research (22)Commentary or Editorial (18)Retracted publication (1) Studies currently recruiting participants only (34)

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Publications and studies (2088)

• Differences in immunoglobulin utilization when treating patients with primary immune disease in the United States. (2025/12/06) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Disseminated BCG infection and rotavirus enteritis in an infant with severe immunodeficiency: a causal association study. (2025/12/05) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Ozone as an Immunomodulator-New Therapeutic Possibilities in the Treatment of Immunodeficiencies-A Narrative Review. (2025/12/05) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. ICF syndrome: An epigenetic paradigm for primary immunodeficiencies. (2025/12/05) ♡
• Standardization of Imaging Criteria for Detecting Macular Fibrosis in Neovascular Age-Related Macular Degeneration. (2025/12/03) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. TYK2 Deficiency Presenting as Refractory Disseminated BCG/Tuberculosis Infection in a Kazakh Child: A Case Report with Genetic Confirmation. (2025/12/02) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. [Van Wyk-Grombach syndrome as a result of late diagnosis of autoimmune thyroiditis (ait) in a patient with chromosome 22 deletion syndrome. Description of the clinical case and a brief review of the literature]. (2025/12/02) ♡
• Risk of HIV viral rebound after SARS-CoV-2 infection among people living with HIV on antiretroviral therapy: a retrospective matched cohort study. (2025/12/01) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. In vitro Control of RNA Virus Infections by M1-Polarized Human Monocyte-Derived Macrophages. (2025/12/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Functional Characterization of an IL2RG Variant, a Case Report of X-Linked T- B + NK + SCID. (2025/12/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Severe SARS-CoV-2 Infection and Campylobacter coli Bacteremia in a Patient With Good's Syndrome. (2025/12/01) ♡
• Exploring the Link between Mental Health and Treatment Adherence in People Living with HIV: A Structured Questionnaire-Based Study. (2025/12/01) ♡
• Persisting infections under IgG substitution: Need for further improvement. (2025/12/01) ♡
• What prevention approaches and technologies are we using? Analysing HIV and AIDS communication campaigns in Brazil. (2025/12/01) ♡
• Randomized researchiParticipants were divided into groups by lottery and compared with each other. This reduces the chance that a difference is due to something other than the treatment. Ozonized sunflower oil as an integrative therapy for feline sporotrichosis: a randomized clinical trial. (2025/12/01) ♡
• Meta-analysisiAll studies on one question combined and calculated together. This is the strongest form of research that exists: a single loose study can be coincidence, dozens together much less so. The label says something about the design, not about the outcome — which can also be that something does NOT work. Moxibustion for human immunodeficiency virus and acquired immunodeficiency syndrome and its complications: a systematic review of randomized controlled trials. (2025/12/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Pulmonary Manifestations of Inborn Errors of Immunity: Diagnostic and Therapeutic Insights. (2025/11/29) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Fulminant liver failure due to Epstein-Barr virus in immunodeficiency disorders. (2025/11/26) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Breastfeeding with HIV in a high-income setting: equipoise and beyond - time to question the zero-risk policy. (2025/11/25) ♡
• Senescent B cells regulate CD38 expression via FOXO1 in pneumonia resulting from PIK3CD (R437C) mutations. (2025/11/25) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. BCGitis and BCGosis: Clinical Spectrum, Immunological Mechanisms, and Risk Management. (2025/11/21) ♡
• Novel de novo dominant PSMB10 variants in three patients with immune deficiency and liver disease. (2025/11/18) ♡
• A Comparison of the Risk of Viral Load Blips in Human Immunodeficiency Virus Patients on Two-Drug Versus Three-Drug Antiretroviral Regimens. (2025/11/12) ♡
• Human adenosine deaminase type 2 deficiency enhances NK cell activation but impairs maturation and function. (2025/11/04) ♡
• Gene Correction of Wiskott-Aldrich syndrome iPS Cells Rescues Proplatelet Defects and Improves Platelet Size. (2025/11/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. ITCH Deficiency Causing Immunodeficiency and Immune Dysregulation. (2025/11/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. CVID Enteropathy Associated With Chronic Norovirus Infection: Background, Clinical Features, and Therapeutic Aspects. (2025/11/01) ♡
• A systematic literature review of CVID reveals pervasive detrimental noninfectious manifestations. (2025/10/24) ♡
• DOCK8 deficiency presenting with sclerosing cholangitis, raised immunoglobulin E, and bronchiectasis: A fatal pediatric case report. (2025/10/23) ♡
• A heterozygous USB1 variant linked to immunodeficiency. (2025/10/22) ♡
• Gene therapy for inborn errors of immunity: past progress, current status and future directions. (2025/10/14) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. [Clinical and genetic analysis of a child with X-linked Hoyeraal-Hreidarsson syndrome due to variant of DKC1 gene and a literature review]. (2025/10/10) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Dual cancers in Ataxia-Telangiectasia: a case report and literature review. (2025/10/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. [Hemophagocytic lymphohistiocytosis]. (2025/10/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Lung metastasis with primary conjunctival mucoepidermoid carcinoma. (2025/10/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Immune reconstitution inflammatory syndrome presenting as genital ulcers due to herpes simplex virus: A case report. (2025/10/01) ♡
• Toll-like Receptor 2 Signaling Abnormalities Are Associated with Clinical Manifestations in Common Variable Immunodeficiency. (2025/09/30) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Oral Squamous Cell Carcinoma in a Patient with Myelodysplastic Syndrome: Report of a Case and Literature Review. (2025/09/13) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Case Report: Hematopoietic stem cell transplantation in an adult patient with X-linked agammaglobulinemia and severe refractory enteropathy. (2025/09/02) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Clinical and Immunological Prognostic Factors With Novel Variants in a Large Cohort of Diacylglycerol Acyltransferase 1 Deficiency. (2025/09/01) ♡
• Tryptophan-kynurenine metabolites associate with inflammation and immunologic phenotypes in common variable immunodeficiency. (2025/09/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Gastrointestinal Manifestations of Common Variable Immunodeficiency: A Mentored Review. (2025/09/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Masquerading as lymphoma: the accelerated phase of Chediak-Higashi syndrome and its novel mutation. (2025/09/01) ♡
• Treatment guidelineiAn official agreement between doctors about how this disease should be treated. This is not a single study but the conclusion of an entire medical field. 2025 US Public Health Service Guidelines for the Management of Occupational Exposures to Human Immunodeficiency Virus and Recommendations for Post-exposure Prophylaxis in Healthcare Settings. (2025/09/01) ♡
• Gastrointestinal Tract Findings in Patients with Primary Immunodeficiency: A Single-Center 6-Year Experience. (2025/08/25) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Activated PI3K Delta Syndrome: A Case Presentation and Literature Review. (2025/08/12) ♡
• p62 Binding to Protein Kinase C Regulates HIV-1 gp120 V3 Loop Induced Microglial Inflammation. (2025/08/01) ♡
• Phase 3 studyiResearch in a large group of patients, the final step before a treatment can be approved. What comes out here carries significant weight. Patient-Reported Outcomes in the Phase III OASIS-HAE Study of Donidalorsen for Hereditary Angioedema. (2025/08/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Unmet needs in autoimmune liver diseases. (2025/08/01) ♡
• Bibliometrics of scientific biomedical publications on Primary Immunodeficiency Diseases in the Arab World (2020-2024). (2025/08/01) ♡

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