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Primary immunodeficiencies (severe)

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Search Period All yearsLast 12 monthsLast 5 years Topic All topicsGeneralNutrition and dietAlternative treatment methods Type of research Any type of researchHighest evidence only (82)Meta-analysis (18)Treatment guideline (8)Randomized Research (24)Phase 3 study (20)Systematic review (12)Clinical Research (661)Review article (238)Early study (phase 1 or 2) (8)Case Description (288)Laboratory or animal research (22)Commentary or Editorial (18)Retracted publication (1) Studies currently recruiting participants only (33)

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Publications and studies (2085)

• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. The Sequestration of Holistic Stress Management Techniques for Adults (2026-02-04) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. A Study About How TAK-881 is Processed by the Body and Side Effects in People With Primary Immunodeficiency Diseases (2026-02-03) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Observational Study of People Living With HIV Treated With CD19-directed CAR T Cell (2026-02-02) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. An Phase Ib/II Clinical Trial of TCC1727 Combination Therapy in Advanced Solid Tumors (2026-01-28) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Sexual Health Access at Retail Pharmacies: Advancing Pharmacy-based Delivery of Primary STI and HIV Prevention for Cisgender Women (2026-01-28) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Adoptive T Lymphocyte Administration for Chronic Norovirus Treatment in Immunocompromised Hosts (2026-01-26) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. A Study of Lanadelumab (Takhzyro) and Icatibant (Firazyr®) in Persons With HAE in China (2026-01-21) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. V-IMMUNE: A Novel Immunoglobulin Therapy for Immunodeficiency (2026-01-20) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Study of BP-SCIG 20% in Patients With Primary Immunodeficiency (PID) (2026-01-16) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Institutional Registry of Rare Diseases (2026-01-14) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Data Collection Study of Patients With Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT With RIC (2026-01-13) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. A Study Observing US Patients With HAE Type I or II Who Take Icatibant to Treat HAE Attacks (2026-01-13) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Severe PID With Lymphoproliferation and Neutropenia (2026-01-08) ♡
• An integrated platform for concurrent structural and single-nucleotide variants improves copy-number detection and reveals pathogenic alleles in undiagnosed Mendelian families. (2025/12/31) ♡
• Mechanistic study of LINC01296 mediating TRIP13 regulation of neuroblastoma progression. (2025/12/31) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Progressive cerebellar ataxia with extensive peripheral telangiectasias in ataxia-telangiectasia. (2025/12/30) ♡
• Prevalence and knowledge about cross-generational sexual relationships among undergraduates in a Nigerian tertiary institution. (2025/12/30) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Unmasking Wiskott-Aldrich Syndrome in Adulthood in a Case of Long-Standing Bleeding, Infections, and Steroid-Induced Morbidity. (2025/12/30) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Rapidly Progressive Disseminated Bacillus Calmette-Guérin Infection (BCGitis) in a 3-Month-Old Infant Without Immunodeficiency: A Case Report. (2025/12/29) ♡
• Development of an Ultrasensitive ELISA Assay for Evaluating HIV-1 Envelope Glycoprotein as a Marker for Targeted Activator of Cell Kill. (2025/12/28) ♡
• Age-Related Patterns of Type II Interferon Immunity: Implications for Intramacrophagic Infections and MSMD Diagnosis During Childhood. (2025/12/26) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Primary Humoral Immunodeficiencies and Bronchiectasis in Adults. (2025/12/26) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Pre-exposure prophylaxis (PrEP) and medications for opioid use disorder for persons who inject drugs: the CHORUS + randomized controlled trial study protocol. (2025/12/25) ♡
• Human immunodeficiency virus recency testing coverage and partner-notification-services among people-living with human immunodeficiency virus in low- and middle-income countries. (2025/12/25) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Human parvovirus B-19 meningitis: a sentinel event unmasking primary immunodeficiency in an infant. (2025/12/23) ♡
• IKAROS regulates human T cell phenotype at a thymic and postthymic level. (2025/12/22) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Longitudinally Extensive Transverse Myelitis and Vasculitis by Cryptococcosis in a Non-HIV Patient: A Case Report. (2025/12/22) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. A man in his 60s with immunodeficiency and hepatitis. (2025/12/22) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Recurrent Talaromyces Marneffei Infection Revealing X-Linked Hyper IgM Syndrome in an HIV-Negative Infant: A Diagnostic and Therapeutic Challenge. (2025/12/19) ♡
• Clinical, Genetic, and Immunological Spectrum of CHAI and LATAIE Patients from a Tertiary Referral Centre in India. (2025/12/19) ♡
• Status of Notifiable Infectious Diseases Reporting in the Republic of Korea: 2024 Surveillance Report. (2025/12/18) ♡
• Knowledge, attitudes and practices of primary care nurses regarding human immunodeficiency virus pre-exposure prophylaxis in Mhlontlo sub-district municipality, Eastern Cape, South Africa. (2025/12/18) ♡
• Beyond the stop: Oxadiazole TRIDs restore LRBA protein expression in nonsense-driven primary immunodeficiency. (2025/12/18) ♡
• Adverse reactions to intravenous immunoglobulin in primary immunodeficiency: a retrospective analysis. (2025/12/18) ♡
• Mendelian susceptibility to mycobacterial disease: Clinical, immunological, and genetic study in India. (2025/12/18) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Case Report: Novel variants in the MYD88 gene (c.104T>C, c.141G>C) in a patient with recurrent abscesses as a cause of type 68 immunodeficiency. (2025/12/17) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Insights into pulmonary lophomoniasis infection in a Bruton's disease patient; A case report study and literature review. (2025/12/17) ♡
• Neurodevelopmental outcomes following hematopoietic cell transplantation for patients with severe combined immunodeficiency (SCID): A PIDTC study. (2025/12/17) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Real-world retrospective cohort study evaluating the tolerability of immune globulin intravenous 10% (BIVIGAM(®)). (2025/12/16) ♡
• A Pathway to High Quality Clinical Trials in IgA Vasculitis Nephritis: Meeting Proceedings From a Multiprofessional International Collaborative Workshop. (2025/12/16) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Granulomatous Lymphocytic Interstitial Lung Disease as the Initial Manifestation of Common Variable Immunodeficiency in a Young Adult. (2025/12/14) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. STAT3 c.1915C > T variant-associated Hyper-IgE syndrome in a child: a case report. (2025/12/12) ♡
• Primary immunodeficiency disorders increase the risk of postoperative complications following total hip and knee arthroplasty: A national matched cohort study. (2025/12/12) ♡
• Newborn screening for SCID and severe T- and B-cell lymphopenia in Ukraine: the first analysis of the results, 2022-2025. (2025/12/11) ♡
• Meta-analysisiAll studies on one question combined and calculated together. This is the strongest form of research that exists: a single loose study can be coincidence, dozens together much less so. The label says something about the design, not about the outcome — which can also be that something does NOT work. Incidence, risk factors and outcomes of BCGosis following BCG vaccination in infants: a systematic review and meta-analyses. (2025/12/11) ♡
• Compassionate Use of Olorofim for Invasive Mold Infections: A Nationwide Observational Study in France. (2025/12/11) ♡
• Risk model based on neutrophil-related genes constructs to assess prognosis and immune landscape in sepsis. (2025/12/11) ♡
• Differences in immunoglobulin utilization when treating patients with primary immune disease in the United States. (2025/12/06) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Disseminated BCG infection and rotavirus enteritis in an infant with severe immunodeficiency: a causal association study. (2025/12/05) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Ozone as an Immunomodulator-New Therapeutic Possibilities in the Treatment of Immunodeficiencies-A Narrative Review. (2025/12/05) ♡

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