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Primary immunodeficiencies (severe)

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Search Period All yearsLast 12 monthsLast 5 years Topic All topicsGeneralNutrition and dietAlternative treatment methods Type of research Any type of researchHighest evidence only (82)Meta-analysis (18)Treatment guideline (8)Randomized Research (24)Phase 3 study (20)Systematic review (12)Clinical Research (661)Review article (238)Early study (phase 1 or 2) (8)Case descriptions (290)Laboratory or animal research (22)Commentary or Editorial (18)Retracted publication (1) Studies currently recruiting participants only (34)

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Publications and studies (2086)

• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Assessment of the State of Health, Quality of Life and Expectations of Patients With Hereditary Angioedema (2023-05-10) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. French CAC-HIV Cohort Study (2023-04-18) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. A Study to Assess the Clinical Efficacy of Donidalorsen (Also Known as Ionis-PKK-LRx and ISIS 721744) in Participants With Hereditary Angioedema (2023-04-03) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Study to Assess the Tolerability and Safety of Ecallantide in Children and Adolescents With Hereditary Angioedema (2023-03-31) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. A Study of Lanadelumab in Persons With Hereditary Angioedema (HAE) Type I or II in North America (2023-03-30) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Status of Dental Care Practices in Patients With Hereditary Angioedema (2023-03-20) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Early Detection of Primary Antibody Deficiencies in Primary Care Facilities by an Algorithm Driven Selection of Serologic Testing in Individuals at Risk. (2023-02-21) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Extraordinarily Fun Training Project in Compulsory Secondary Education - Sexually Transmitted Infections (2023-02-14) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Intensive Care Unit and Secondary and Primary Immune Deficiency (2023-02-13) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. A Study About Low Blood Pressure in Patients With Primary Immunodeficiency Disease Treated With Immune Globulin Products (2023-02-01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Study to Evaluate Safety and Pharmacokinetics of BIVIGAM® in Primary Immune Deficiency Subjects Aged 2 to 16 (2023-02-01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Comparative Bioavailability of Betamethasone Oral Solution Metered Spray (GTX-102) in Healthy Subjects (2023-01-23) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. A Study in Teenagers and Adults With Hereditary Angioedema (HAE) Type I or Type II Who Use Lanadelumab as Long-Term Prophylaxis (2023-01-13) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Post-Authorization Safety, Tolerability, and Immunogenicity Evaluation of HyQvia in Pediatric PIDD Subjects (2023-01-11) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Seroincidence Study Among Men Who Have Sex With Men and Transgender Women - The ImPrep Seroincidence Study (2023-01-06) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Efavirenz: History, Development and Future. (2022/12/31) ♡
• Iatrogenic immunodeficiency-associated lymphoproliferative disorders of the central nervous system: a treatment paradox. (2022/12/31) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Clinical characteristics associated with mortality of COVID-19 patients admitted to an intensive care unit of a tertiary hospital in South Africa. (2022/12/30) ♡
• Loneliness and mortality in cats: A single institution necropsy study of 3108 cases (1989-2019). (2022/12/29) ♡
• Loss of Function TGFBR2 Variant as a Contributing Factor in Generalized Pustular Psoriasis and Adult-Onset Immunodeficiency. (2022/12/29) ♡
• Cumulative Human Immunodeficiency Virus (HIV) -1 Viremia Is Associated With Increased Risk of Multimorbidity Among US Women With HIV, 1997-2019. (2022/12/28) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Case report: Challenges in immune reconstitution following hematopoietic stem cell transplantation for CTLA-4 insufficiency-like primary immune regulatory disorders. (2022/12/27) ♡
• Interstitial Lung Disease in Immunocompromised Children. (2022/12/26) ♡
• A Retrospective Study on the Efficacy of Subcutaneous Immunoglobulin as Compared to Intravenous Formulation in Patients with Chronic Lymphocytic Leukemia and Secondary Antibody Deficiency. (2022/12/25) ♡
• Immunoglobulin replacement therapy in patients with immunodeficiencies: impact of infusion method on patient-reported outcomes. (2022/12/24) ♡
• Identification of a novel WAS mutation and the non-splicing effect of a second-site mutation in a Chinese pedigree with Wiskott-Aldrich syndrome. (2022/12/22) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. A Novel Tongue Squamous Cell Carcinoma Cell Line Escapes from Immune Recognition due to Genetic Alterations in HLA Class I Complex. (2022/12/22) ♡
• SARS-CoV-2 booster vaccination results attenuated IgG1 memory B cell response in primary antibody deficiency patients. (2022/12/22) ♡
• Insights into mucosal associated invariant T cell biology from human inborn errors of immunity. (2022/12/22) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Autoimmunity and Immunodeficiency in Severe SARS-CoV-2 Infection and Prolonged COVID-19. (2022/12/21) ♡
• Predictors of first-line antiretroviral treatment failure among children on antiretroviral therapy at the University of Gondar comprehensive specialised hospital, North-West, Ethiopia: a 14-year long-term follow-up study. (2022/12/20) ♡
• Dominant-negative signal transducer and activator of transcription (STAT)3 variants in adult patients: A single center experience. (2022/12/20) ♡
• Mapping age- and sex-specific HIV prevalence in adults in sub-Saharan Africa, 2000-2018. (2022/12/19) ♡
• The Effect of Heterozygous Mutation of Adenylate Kinase 2 Gene on Neutrophil Differentiation. (2022/12/17) ♡
• Frontier and hotspot evolution in Wiskott-Aldrich syndrome: A bibliometric analysis from 2001 to 2021. (2022/12/16) ♡
• Ataxia-Telangiectasia Mutated Loss of Heterozygosity in Melanoma. (2022/12/16) ♡
• Care of patients with inborn errors of immunity in thirty J Project countries between 2004 and 2021. (2022/12/16) ♡
• Human Immunodeficiency Virus Type 1 RNA Genital Tract Shedding After Cryotherapy for Cervical Intraepithelial Neoplasia in Western Kenya. (2022/12/16) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. BTK inhibitor combined with anti-PD-1 monoclonal antibody for the treatment of CD20-negative primary central nervous system lymphoma: A case report. (2022/12/15) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Ten-year population trends of immunoglobulin use, burden of adult antibody deficiency and feasibility of subcutaneous immunoglobulin (SCIg) replacement in Hong Kong Chinese. (2022/12/14) ♡
• Integrated bioinformatics analysis of IFITM1 as a prognostic biomarker and investigation of its immunological role in prostate adenocarcinoma. (2022/12/14) ♡
• Complications of rabbit anti-thymocyte globulin induction immunosuppression in HIV-infected kidney transplant recipients. (2022/12/14) ♡
• Challenges in Gene Therapy for Somatic Reverted Mosaicism in X-Linked Combined Immunodeficiency by CRISPR/Cas9 and Prime Editing. (2022/12/13) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. X-Linked Agammaglobulinemia Leading to Chronic Obstructive Lung Disease. (2022/12/13) ♡
• Diversity of malignancies in patients with different types of inborn errors of immunity. (2022/12/12) ♡
• The Impact of a Walk-in Human Immunodeficiency Virus Care Model for People Who Are Incompletely Engaged in Care: The Moderate Needs (MOD) Clinic. (2022/12/12) ♡
• Evaluation of S- and M-Proteins Expressed in Escherichia coli and HEK Cells for Serological Detection of Antibodies in Response to SARS-CoV-2 Infections and mRNA-based Vaccinations. (2022/12/10) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Transcriptomic insights into the role of the spleen in a mouse model of Wiskott‑Aldrich syndrome. (2022/12/09) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Editorial: DADA2 and other monogenic vasculitides. (2022/12/08) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Case report: Persistent shedding of a live vaccine-derived rubella virus in a young man with severe combined immunodeficiency and cutaneous granuloma. (2022/12/08) ♡

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