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Primary immunodeficiencies (severe)

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Search Period All yearsLast 12 monthsLast 5 years Topic All topicsGeneralNutrition and dietAlternative treatment methods Type of research Any type of researchHighest evidence only (82)Meta-analysis (18)Treatment guideline (8)Randomized Research (24)Phase 3 study (20)Systematic review (12)Clinical Research (661)Review article (238)Early study (phase 1 or 2) (8)Case Description (288)Laboratory or animal research (22)Commentary or Editorial (18)Retracted publication (1) Studies currently recruiting participants only (33)

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Publications and studies (2085)

• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Hospital dental management as an adjunct to systemic therapy in refractory oral candidiasis in severe combined immunodeficiency. (2026/09/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. HIV Preventive Measures' Adoption Among Men Who Have Sex With Men in West and Central Africa: A Scoping Review On Pre-exposure Prophylaxis and Condom Use. (2026/08/10) ♡
• Clinical and Economic Burden of Autologous Skin Grafting for Nonthermal Full-Thickness Wounds Across Care Settings: A US Retrospective Claims Study. (2026/08/10) ♡
• Randomized researchiParticipants were divided into groups by lottery and compared with each other. This reduces the chance that a difference is due to something other than the treatment. Efficacy and safety of the Chinese herbal medicine Yiaikang capsule in treating AIDS: a randomized, double-blind, controlled trial. (2026/08/10) ♡
• Phase 3 studyiResearch in a large group of patients, the final step before a treatment can be approved. What comes out here carries significant weight. High-dose chemotherapy followed by autologous stem-cell transplantation versus non-myeloablative consolidation in primary CNS lymphoma (MATRix/IELSG43): a randomised phase 3 trial. (2026/08/08) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Lanadelumab Use for Hereditary Angioedema Long-Term Prophylaxis Over the Last 7 Years: A Narrative Review of Clinical and Real-World Data. (2026/08/08) ♡
• Safety and tolerability of a new intravenous immunoglobulin 10% in patients with primary immunodeficiency. (2026/08/07) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. CRISPR-Cas9 gene editing approaches in colorectal cancer: Current progress and future prospects. (2026/08/07) ♡
• Impaired immune response to polysaccharide antigens and warning signs in children with recurrent respiratory infections. (2026/08/06) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Gastrointestinal manifestations of common variable immunodeficiency: what a gastroenterologist needs to be aware of. (2026/08/06) ♡
• Systematic and proactive evaluation of AIRE missense variant effects. (2026/08/06) ♡
• The heparan sulfate mimetic PI-88 is a potent inhibitor of HIV-1 independently of its anti-heparanase activity. (2026/08/05) ♡
• Multiyear Recurrent Pericarditis Disease Duration: Clinical Outcomes After Cessation of Long-Term Interleukin-1 Pathway Inhibition Provide Insights for Chronic Management. (2026/08/04) ♡
• Functional restoration of immune defects in STAT1 gain-of-function disease following stem cell gene editing. (2026/08/04) ♡
• Ensitrelvir in hospitalized patients with COVID-19 who were moderately to severely immunocompromised: a single-center cohort study. (2026/08/04) ♡
• Burden and determinants of self-reported non-communicable disease comorbidities among HIV positive adults in Tanzania: insights from the Tanzania HIV Impact Survey 2022-2023. (2026/08/03) ♡
• Assessing Overall and Mental/Emotional Health Among People Living With HIV/AIDS. (2026/08/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. The Hidden Burden: Endocrinopathies in Adolescents after Hematopoietic Stem Cell Transplantation. (2026/08/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Gastrointestinal Adverse Events Following Rotavirus Vaccination in Children: A Systematic Review. (2026/08/01) ♡
• Prevalence of Drug Allergy Labels Among Pediatric Patients With Inborn Errors of Immunity. (2026/08/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. The Structure of Vertebrate Antigen Receptor Repertoires: An Evolutionary Perspective. (2026/08/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Tricho-Hepato-Enteric Syndromic Immunodeficiency: Clinical Spectrum, Pathobiology, and Emerging Therapies. (2026/08/01) ♡
• Granulomatous Lymphocytic Interstitial Lung Disease in Common Variable Immunodeficiency. (2026/08/01) ♡
• Phase 3 Trial of Weekly Oral Islatravir-Lenacapavir for HIV-1 Treatment. (2026/07/29) ♡
• Allogeneic hematopoietic cell transplantation is curative in CARMIL2 deficiency. (2026/07/29) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Evolution of Inborn Errors of Immunity in China: Discoveries and Treatment Paradigms. (2026/07/28) ♡
• The rebound-initiating viral reservoir (RIVR) in SIV/SHIV infection is dominated by plasma virus sequences present at the time of ART initiation. (2026/07/28) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Multidisciplinary approach to early identification of inborn errors of immunity in patients with lymphoproliferation. (2026/07/28) ♡
• 2026 ISH guidelines for the management of hypertension in Africa: the International Society of Hypertension (ISH) African Regional Advisory Group and the Pan African Society of Cardiology (PASCAR). (2026/07/28) ♡
• Novel pathogenic CTLA4 missense variant associated with autoimmune enteropathy and systemic immune dysregulation. (2026/07/27) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. How I treat: Diagnostic clues and treatment for activated phosphoinositide 3-kinase delta syndrome. (2026/07/27) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Mechanical versus Electronic Infusion Systems in Subcutaneous Immunoglobulin Therapy: A Structured Literature Review of Infusion-Site Reactions and Device Performance. (2026/07/27) ♡
• Support needs for chronic disease self-management among persons attending a Primary Health Care facility in Victor Khanye, Mpumalanga. (2026/07/27) ♡
• Persistently Elevated Serum IgM: A Diagnostic Red Flag for Primary Immunodeficiencies: A Case-Based Review and Clinical Approach. (2026/07/27) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. [Construction of a chimeric cell model expressing human immunodeficiency virus-1 envelope protein based on transposon system and evaluation of chimeric antigen receptor t-cell cytotoxicity in vitro]. (2026/07/25) ♡
• Geographic Barriers to Subspecialty Care Access for Patients with Primary Immune Disorders in the United States. (2026/07/24) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Invasive pneumococcal disease unmasks monoclonal immunoglobulins and antibody deficiencies: a multicenter prospective study in adults. (2026/07/24) ♡
• Longitudinal changes in inflammatory markers and body weight in adults with primary immunodeficiency receiving immunoglobulin replacement therapy: A retrospective cohort study. (2026/07/24) ♡
• [Professional practices and commitments in the care of people living with HIV/AIDS]. (2026/07/24) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Case Report: Papillon-Lefèvre syndrome beyond keratoderma: two index presentations and sibling screening in two families. (2026/07/24) ♡
• Clinical and Laboratory Features of Pediatric Agammaglobulinemia: A Comparative Analysis of Classical, Common Variable Immunodeficiency, and Syndromic Forms. (2026/07/23) ♡
• Psycho-social-cultural barriers among sexual minority men living with HIV in Nigeria. (2026/07/23) ♡
• Eczema in inborn errors of immunity with atopy: frequency, timing, phenotypic clustering. (2026/07/22) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Splenectomy revisited in Wiskott-Aldrich syndrome in the era of HSCT and gene therapy: a bridge, a rescue, or simply obsolete? (2026/07/22) ♡
• A systematic review and meta synthesis of barriers and facilitators to Black women's participation in healthcare research. (2026/07/21) ♡
• Preserved SARS-CoV-2 T-cell responses despite impaired humoral immunity in children with profound B-cell lymphopenia. (2026/07/20) ♡
• Long-term predictors of recurrence in pediatric recurrent respiratory papillomatosis. (2026/07/19) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. DADA2 as a Model of Monogenic Immune Vasculopathy: From Immunopathogenesis to Precision Therapeutics. (2026/07/19) ♡
• Inflammatory mediators are predictors of clinical outcomes in cirrhotic patients with non-acute decompensation. (2026/07/17) ♡
• A hybrid type 2 cluster randomized trial of an enhanced combined cognitive behavioral therapy and medication management algorithm for treatment of depression among youth living with HIV: study protocol. (2026/07/17) ♡

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