← All diseases Lungs and airways

Alpha-1 antitrypsin deficiency

Automatically tracked from PubMed and ClinicalTrials.gov, newest on top. Nothing ever disappears here: what you keep in your favorites remains findable. · RSS feed of this disease · only the strongest evidence

Search Period All yearsLast 12 monthsLast 5 years Topic All topicsGeneralNutrition and dietAlternative treatment methods Type of research Any type of researchHighest evidence only (32)Meta-analysis (8)Treatment guideline (5)Randomized trial (8)Systematic review (6)Phase 3 study (5)Clinical trial (181)Review article (176)Early study (phase 1 or 2) (9)Case report (114)Laboratory or animal study (26)Commentary or editorial (90)Retracted publication (1)

Filter

Publications and studies (1172)

• Undetected mutations across different serum alpha1 antitrypsin thresholds: An analysis of the avatar cohort. (2026/12/01) ♡
• Characterization of US patients with alpha-1 antitrypsin deficiency treated with an alpha-1 proteinase inhibitor. (2026/12/01) ♡
• p62/SQSTM1-KEAP1 complex prevents clearance of ubiquitinated Z alpha-1 antitrypsin and aggravates liver proteotoxicity. (2026/08/07) ♡
• Small airway dysfunction across alpha-1 antitrypsin deficiency genotypes with preserved spirometry. (2026/08/01) ♡
• Amplification of genetic and metabolic factors in alpha-1 antitrypsin deficiency. (2026/08/01) ♡
• Meta-analysisiAll studies on one question combined and calculated together. This is the strongest form of research that exists: a single loose study can be coincidence, dozens together much less so. The label says something about the design, not about the outcome — which can also be that something does NOT work. Meta-Analysis: Redefining Liver Disease Risk in Heterozygous Alpha-1 Antitrypsin Deficiency. (2026/08/01) ♡
• Treatment guidelineiAn official agreement between doctors about how this disease should be treated. This is not a single study but the conclusion of an entire medical field. Reproductive health guidance for the cystic fibrosis community: a Cystic Fibrosis Foundation Position Paper. (2026/08/01) ♡
• Pizza versus Pi*ZZ: The metabolic amplifiers in alpha-1 antitrypsin deficiency. (2026/08/01) ♡
• Emphysema in an 11-month-old boy with alpha-1 antitrypsin deficiency. (2026/07/30) ♡
• From one-size-fits-all to on-demand: personalized crispr gene editing for rare genetic liver diseases. (2026/07/28) ♡
• Gene Therapy: Knowledge, Attitudes, and Preferences Among Individuals with Alpha-1 Antitrypsin Deficiency. (2026/07/22) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Base editing for precision therapeutics. (2026/07/22) ♡
• Evaluating Alpha-1 Antitrypsin Deficiency testing across Europe to ensure diagnostic accuracy: an EARCO multicentre project. (2026/07/21) ♡
• Coexistence of Multiple Endocrine Neoplasia Type 2B and Centri-Acinar Emphysema With Alpha-1 Antitrypsin Deficiency: A Case Report. (2026/07/14) ♡
• Community-Based SERPINA1 Genotyping in an Isolated Alpine Town Reveals Heterozygous Pi*Mheerlen Carriers: Implications for Targeted Screening. (2026/07/10) ♡
• Delineating a reference interval for functional alpha-1 antitrypsin in the serum of healthy Pi*MM donors using an anti-neutrophil elastase capacity assay. (2026/07/09) ♡
• Clinical phenotypes in α(1)-antitrypsin deficiency: a cluster analysis on EARCO data. (2026/07/06) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Routine Blood Biomarkers in Patients With the PI*SZ Genotype of Alpha-1 Antitrypsin Deficiency: Data From the EARCO Registry. (2026/07/01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Demographic and Physiological Differences Between Fibrotic and Nonfibrotic CT Subtypes of Sarcoidosis. (2026/07/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Advancing Precision Approaches to Chronic Obstructive Pulmonary Disease. (2026/07/01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Affinity Proteomics-Based Non-Invasive Detection of Clinically Significant Liver Disease. (2026/07/01) ♡
• Optimization of Alpha-1 Antitrypsin Expression from Adeno-Associated Virus Vectors. (2026/07/01) ♡
• Alpha-1 Antitrypsin Deficiency Alleles in Non-Cirrhotic Hepatocellular Carcinoma: Insights from a Multicenter French Cohort. (2026/07/01) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Glycoengineered Recombinant Alpha1-Antitrypsin Results in Comparable In Vitro and In Vivo Activities to Human Plasma-Derived Protein. (2026/07/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Connecting the dots: historical perspective on lung volume reduction. (2026/06/30) ♡
• The epidemiological burden and societal cost of 14 respiratory conditions in the World Health Organization European region: systematic evidence map and economic analysis. (2026/06/29) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Case Report: Early recognition of neonatal alpha-1 antitrypsin deficiency: a case of subtle presentation and prompt diagnosis. (2026/06/24) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Dissociation of the Hepatic and Pulmonary Axes in Alpha-1 Antitrypsin Deficiency: Independent Trajectories of Organ-Specific Disease. (2026/06/24) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Immunotherapy-related interstitial lung disease: a call to improve risk stratification and diagnostic consistency. (2026/06/22) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Hepatic Alpha-1 Antitrypsin Globules in Compound Heterozygous SERPINA1 Variants Previously Considered Non-Polymerizing: A Case Report. (2026/06/20) ♡
• Retraction: The Irish National Alpha-1 Antitrypsin Deficiency (AATD) Registry: Examining the Prevalence of Radiological Abnormalities in a Population With Severe AATD. (2026/06/18) ♡
• Treatment guidelineiAn official agreement between doctors about how this disease should be treated. This is not a single study but the conclusion of an entire medical field. Spanish Clinical Practice Guidelines for the Diagnosis and Management of Alpha-1 Antitrypsin Deficiency: 2026 Update. (2026/06/13) ♡
• Biophysical and Computational Insights into Alpha-1 Antitrypsin Aggregation and Its Inhibition by Natural Polyphenols. (2026/06/09) ♡
• Loss of the Mechanistic Target of Rapamycin Complex 1 Causes a Lethal Alpha-1 Antitrypsin Deficiency-Associated Liver Disease. (2026/06/04) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Alpha-1 antitrypsin: therapeutic applications beyond serine protease inhibition. (2026/06/01) ♡
• Systematic reviewiAll research on one question is searched according to fixed rules and compared side by side, so that no studies with poor outcomes are missed. The Relationship Between Gas Transfer Measurements, Lung Volumes, and Spirometric Indices in Alpha-1 Antitrypsin Deficiency and Non-AATD COPD: A Systematic Review. (2026/05/28) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. The Association of Alpha-1 Antitrypsin Deficiency and Arterial Aneurysms: An Update and Review. (2026/05/28) ♡
• Clinical Characteristics and Health Care Resource Utilization Among Individuals Undergoing Alpha-1 Antitrypsin Testing in a Quaternary Health System. (2026/05/27) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. The Role of Alpha-1 Antitrypsin in the Pathophysiology and Treatment of Inflammatory Lung Diseases. (2026/05/23) ♡
• Primary ciliary dyskinesia in pediatric persons: A microscopic movement malady. (2026/05/14) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. The Metabolic Architecture of Glaucoma: A Unified Framework of Cofactor Failure and Kynurenine Dysregulation. (2026/05/12) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Making the case to highlight the burden of respiratory diseases in Europe. (2026/05/07) ♡
• Retracted publicationiThis research has been withdrawn by science itself, for example due to a flaw in the method or unreliable data. Do not use it as support and do not discuss it as evidence. The Irish National Alpha-1 Antitrypsin Deficiency (AATD) Registry: Examining the Prevalence of Radiological Abnormalities in a Population With Severe AATD. (2026/05/04) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. In Response to Increased Risk of Cholesteatoma in Individuals With Alpha-1 Antitrypsin Deficiency: A Cohort Study. (2026/05/01) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. In Reference to Increased Risk of Cholesteatoma in Individuals With Alpha-1 Antitrypsin Deficiency: A Cohort Study. (2026/05/01) ♡
• Quantitative CT of emphysema, wall thickness and mucus plugs in alpha-1-antitrypsin deficiency: relationship to clinical outcomes. (2026/05/01) ♡
• The Alpha-1 Pi*MZ Genotype Is an Independent Risk Factor for Hepatocellular Carcinoma Development in Patients With ACLD. (2026/05/01) ♡
• Alpha-1 Antitrypsin Replacement Improves Walking Capacity in Subjects With Severe Deficiency. (2026/05/01) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. BMN 349, a small molecule inhibitor of Z alpha-1 antitrypsin polymerization, increases secretion and reduces intrahepatic inclusions in a mouse model of disease. (2026/05/01) ♡
• Meta-analysisiAll studies on one question combined and calculated together. This is the strongest form of research that exists: a single loose study can be coincidence, dozens together much less so. The label says something about the design, not about the outcome — which can also be that something does NOT work. Prevalence of liver disease and liver transplantation in pediatric ZZ alpha-1 antitrypsin deficiency: A systematic review and meta-analysis. (2026/05/01) ♡

↑ Back to top

codex.care does not provide medical advice. Always discuss symptoms, medication, and treatment choices with your own healthcare provider.