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Thalassemia (severe form)

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Search Period All yearsLast 12 monthsLast 5 years Topic All topicsGeneralNutrition and dietAlternative treatment methods Type of research Any type of researchHighest level of evidence only (54)Meta-analysis (12)Treatment guideline (1)Randomized trial (20)Systematic review (12)Phase 3 study (9)Clinical trial (378)Review article (138)Early study (phase 1 or 2) (18)Case report (134)Laboratory or animal research (17)Commentary or editorial (44)Retracted publication (2) Studies currently recruiting participants only (32)

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Publications and studies (1521)

• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. NAC Effect on Iron Overload and Blood Transfusion in β-thalassemia Major (2023-08-23) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Growth and Development-related Outcomes in Children With Transfusion-dependent Beta-thalassemia After Gene Therapy (2023-08-14) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Cardiac Management of Patients With Thalassemia Minor and Breast Cancer (2023-07-25) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Assessment of Cognitive Function, Fatigue and Health Related Quality of Life in Children With Beta Thalassemia (2023-06-22) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Study to Determine the Safety and Tolerability of Sotatercept (ACE-011) in Adults With Beta (β)- Thalassemia. (2023-06-18) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. A Study Evaluating the Efficacy and Safety of the LentiGlobin® BB305 Drug Product in Participants With Transfusion-Dependent β-Thalassemia, Who do Not Have a β0/β0 Genotype (2023-06-18) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Enhancing Use of Hydroxyurea In Sickle Cell Disease Using Patient Navigators (2023-06-02) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Pumilio1 (PUM1) Expression, Sickle Cell Anemia, β-thalassemia Intermedia (2023-05-31) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. A Study Evaluating the Safety and Efficacy of LentiRed Drug Product in Transfusion-dependent β-Thalassemia [TDT] (2023-05-09) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. An Efficacy and Safety Study of Luspatercept (ACE-536) Versus Placebo in Adults Who Require Regular Red Blood Cell Transfusions Due to Beta (β) Thalassemia (2023-04-18) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. The Relevance Between the Level of Fetal Hemoglobin and Short-term Complications in Extremely Preterm Infants (2023-03-29) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Dose-Escalation Study of SCD-101 in Sickle Cell Disease (2023-03-21) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. PK of SOF/LED in HCV - Infected Adolescents With Haematological Disorders (2023-03-06) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Phase I/II Pilot Study of Mixed Chimerism to Treat Hemoglobinopathies (2023-03-03) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. The Prevalence of HBB c.93-21 G-A in β Thalassemia Patients (2023-01-31) ♡
• Hematological Parameters and Demographic Distribution of Hemoglobinopathies and Various Hemoglobin Variants. (2022/12/29) ♡
• A Cell-Permeant Nanobody-Based Degrader That Induces Fetal Hemoglobin. (2022/12/28) ♡
• Effects of green tea extract treatment on erythropoiesis and iron parameters in iron-overloaded β-thalassemic mice. (2022/12/23) ♡
• Incidental Detection of a Chromosomal Aberration by Array-CGH in an Early Prenatal Diagnosis for Monogenic Disease on Coelomic Fluid. (2022/12/21) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. A case report of H-syndrome from Baghdad Medical City treated with tocilizumab. (2022/12/19) ♡
• Increased risk of eclampsia and preeclampsia during delivery hospitalizations in women with beta-thalassemia; An analysis of the National Inpatient Sample database. (2022/12/19) ♡
• Insulin-Like Growth Factor -1 (IGF-1) and Glucose Dysregulation in Young Adult Patients with β-Thalassemia Major: Causality or Potential Link? (2022/12/16) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Complications in Transfusion-Dependent Thalassemia. (2022/12/15) ♡
• Correlation of Transient Elastography With MRI T2* and Serum Ferritin Levels in Children With Transfusion-Dependent Thalassemia. (2022/12/15) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Thalassemia: A Review of the Challenges to the Families and Caregivers. (2022/12/13) ♡
• Transcranial Doppler ultrasonography in patients with hemoglobinopathy: An experience from a tertiary center. (2022/12/13) ♡
• Deferiprone, an iron chelator, alleviates platelet hyperactivity in patients with β-thalassaemia/HbE. (2022/12/12) ♡
• Metabolomics Study of Serum Samples of β-YAC Transgenic Mice Treated with Tenofovir Disoproxil Fumarate. (2022/12/12) ♡
• Hemoglobinopathy is Associated With Total Hip Arthroplasty Indication Even Beyond Sickle Cell Anemia. (2022/12/10) ♡
• Evaluation of the efficacy of signal-averaged electrocardiogram testing in the cardiac assessment of beta-thalassemia major patients. (2022/12/07) ♡
• Feasibility of combining short tandem repeats (STRs) haplotyping with preimplantation genetic diagnosis (PGD) in screening for beta thalassemia. (2022/12/07) ♡
• Endocrine Complications and the Effect of Compliance with Chelation Therapy in Patients with Beta Thalassemia Major in Eastern Province of Saudi Arabia. (2022/12/07) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Perforated duodenal ulcer secondary to deferasirox use in a child successfully managed with laparoscopic drainage: A case report. (2022/12/06) ♡
• Long-term safety and erythroid response with luspatercept treatment in patients with β-thalassemia. (2022/12/05) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. The Optimized γ-Globin Lentiviral Vector GGHI-mB-3D Leads to Nearly Therapeutic HbF Levels In Vitro in CD34(+) Cells from Sickle Cell Disease Patients. (2022/12/05) ♡
• A MALDI-TOF mass spectrometry-based haemoglobin chain quantification method for rapid screen of thalassaemia. (2022/12/01) ♡
• Systematic reviewiAll research on one question is searched according to fixed rules and compared side by side, so that no studies with poor outcomes are missed. Prevalence of Cardiovascular Complications in Individuals with Sickle Cell Anemia and Other Hemoglobinopathies: A Systematic Review. (2022/12/01) ♡
• Extramedullary Hematopoiesis Visualized on FDG-PET/CT in a Patient with Beta-Thalassemia. (2022/12/01) ♡
• [Expression Levels of MiR-451 in Erythroid Differentiation and Its Correlation with Hematological Diseases]. (2022/12/01) ♡
• Application of third-generation sequencing for genetic testing of thalassemia in Guizhou Province, Southwest China. (2022/12/01) ♡
• Thalassaemia - part 2: the patient perspective. (2022/12/01) ♡
• Novel Decision Tool for More Severe α-Thalassemia Genotypes Screening with Functional Loss of Two or More α-Globin Genes: A Diagnostic Test Study. (2022/12/01) ♡
• Peripheral Neuropathy in Beta-Thalassemia: Corneal Confocal Microscopy-Based Study. (2022/12/01) ♡
• Auditory Brainstem Response in Children with Thalassemia Major under Chelating Therapy. (2022/12/01) ♡
• Molecular and hematological studies in a cohort of beta zero South East Asia deletion (β°-thal SEA) from Malaysian perspective. (2022/11/30) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Markers of Renal Complications in Beta Thalassemia Patients with Iron Overload Receiving Chelation Agent Therapy: A Systematic Review. (2022/11/28) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Whole-exome sequencing analysis of amniotic fluid cells in 5 pregnant women with thalassemia: Case report. (2022/11/25) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Kruppel-like factor 1-GATA1 fusion protein improves the sickle cell disease phenotype in mice both in vitro and in vivo. (2022/11/24) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Intracranial extramedullary hematopoiesis in a patient with beta-thalassemia presenting with head trauma. (2022/11/18) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Use of cell salvage and HBOC-201 in a pregnant Jehovah's Witness with sickle beta+thalassaemia undergoing emergency caesarean section. (2022/11/17) ♡

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