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Mitochondrial diseases

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Search Period All yearsLast 12 monthsLast 5 years Topic All topicsGeneralNutrition and dietAlternative treatment methods Type of research Any type of researchHighest level of evidence only (34)Meta-analysis (3)Treatment guideline (1)Systematic review (16)Randomized trial (11)Phase 3 study (3)Clinical Trial (599)Review article (684)Early-stage study (phase 1 or 2) (13)Laboratory or animal research (269)Case Description (79)Commentary or Editorial (11)Retracted Publication (9) Studies currently recruiting participants only (30)

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Publications and studies (3448)

• Bone marrow mesenchymal stem cells ameliorate diet-induced obesity by activating thermogenesis and alleviating inflammation in adipose tissue. (2025/02/02) ♡
• Mir221- and Mir222-enriched adsc-exosomes mitigate PM exposure-exacerbated cardiac ischemia-reperfusion injury through the modulation of the BNIP3-MAP1LC3B-BBC3/PUMA pathway. (2025/02/01) ♡
• Jinlida granules alleviate podocyte apoptosis and mitochondrial dysfunction via the AMPK/PGC‑1α pathway in diabetic nephropathy. (2025/02/01) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Integrated HPLC, pharmacodynamics, and immunoprofiling to explore active components and mechanism of Zhi Bai Heye Fang on glycolipid metabolic disorders in mice. (2025/02/01) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Proteomics analysis in rats reveals convergent mechanisms between major depressive disorder and dietary zinc deficiency. (2025/02/01) ♡
• Systematic reviewiAll research on one question is searched according to fixed rules and compared side by side, so that no studies with poor outcomes are missed. Betaine and aging: A narrative review of findings, possible mechanisms, research perspectives, and practical recommendations. (2025/02/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Molecular mechanisms and potential interventions during aging-associated sarcopenia. (2025/02/01) ♡
• Inhibition of L-threonine dehydrogenase from Trypanosoma cruzi reduces glycine and acetate production and interferes with parasite growth and viability. (2025/02/01) ♡
• Evolution of Lipid Metabolism in the Injured Mouse Spinal Cord. (2025/02/01) ♡
• Disruption of deoxyribonucleotide triphosphate biosynthesis leads to RAS proto-oncogenic activation and perturbation of mitochondrial metabolism. (2025/02/01) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. NXT629 Ameliorates Cholesterol Gallstones in Mice Model by Improving Lipid Metabolism Disorder and Cholesterol Homeostasis Through Inhibiting the GPAM Pathway. (2025/02/01) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Hederagenin ameliorates ferroptosis-induced damage by regulating PPARα/NRF2/GPX4 signaling pathway in HT22 cells: An in vitro and in silico study. (2025/02/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Mitochondria and myocardial ischemia/reperfusion injury: Effects of Chinese herbal medicine and the underlying mechanisms. (2025/02/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. DRP1: shedding light on the complex nexus of mitochondrial fission and breast cancer. (2025/02/01) ♡
• Pan AMPK activation protects tubules in rat ischemic acute kidney injury. (2025/02/01) ♡
• Escalomol rescues mitochondrial copper deficiency in disease models without triggering cuprotosis. (2025/02/01) ♡
• Uncovering the pharmacological mechanism and the main herbal medicine contributing to the efficacy of Xiaoyanlidan Tablet (XYLDT) in treating cholestatic liver injury. (2025/01/31) ♡
• Mechanistic study of the regulation of mitochondrial function by the gpnmb/nrf2/NF-κB signaling pathway mediated by Quzhi Tang to alleviate chondrocyte senescence. (2025/01/31) ♡
• Modified Tou Nong Powder obstructs ulcerative colitis by regulating autophagy and mitochondrial function. (2025/01/31) ♡
• Buyang huanwu decoction inhibits the activation of the RhoA/rock2 signaling pathway through the phenylalanine metabolism pathway, thereby reducing neuronal apoptosis following cerebral ischemia-reperfusion injury. (2025/01/31) ♡
• Jingfang Granule promotes the tricarboxylic acid cycle to improve chronic fatigue syndrome by increasing the expression of Idh1 and Idh2. (2025/01/31) ♡
• Astragalus membranaceus-Carthamus tinctorius herb pair antagonizes parthanatos in cerebral ischemia/reperfusion injury via regulating PARP-1/TAX1BP1-mediated mitochondrial respiratory chain complex I. (2025/01/31) ♡
• Rostellularia procumbens (L) Nees. extract attenuates adriamycin-induced nephropathy by maintaining mitochondrial dynamics balance via SIRT1/PGC-1α signaling pathway activation. (2025/01/31) ♡
• Against Qinlian Decoction inhibits liver ferroptosis in type 2 diabetes mellitus models by targeting Nrf2. (2025/01/31) ♡
• Association between folate and glutamine metabolism and prognosis of kidney cancer. (2025/01/31) ♡
• Comparison of chemical composition between imitation wild and transplanted Astragali Radix and their therapeutic effects on heart failure. (2025/01/30) ♡
• Study on the role of Dihuang Yinzi in regulating the AMPK/SIRT1/PGC-1α pathway to promote mitochondrial biogenesis and improve Alzheimer's disease. (2025/01/30) ♡
• Po-Ge-Jiu-Xin decoction alleviate sepsis-induced cardiomyopathy via regulating phosphatase and tensin homolog-induced putative kinase 1 /parkin-mediated mitophagy. (2025/01/30) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Yimu-qinggong san alleviates lipopolysaccharide-induced endometritis in mice via inhibiting inflammation and oxidative stress through regulating macrophage polarization. (2025/01/30) ♡
• Effect of potato glycoside alkaloids on mitochondria energy metabolism of Fusarium solani, the root rot pathogen of Lycium barbarum. (2025/01/29) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. 4-Aminoquinoline as a privileged scaffold for the design of leishmanicidal agents: structure-property relationships and key biological targets. (2025/01/29) ♡
• Licorice and dried ginger decoction inhibits inflammation and alleviates mitochondrial dysfunction in chronic obstructive pulmonary disease by targeting siglec-1. (2025/01/27) ♡
• Inhibition of ZFP281/ZNF281-RIPK1/RIPK3/MLKL signaling in hepatocytes by pterostilbene relieves hepatic lipometabolic disorder and inflammation in non-alcoholic steatohepatitis. (2025/01/27) ♡
• Identification and preliminary validation of biomarkers associated with mitochondrial and programmed cell death in pre-eclampsia. (2025/01/23) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Sirtuins in kidney homeostasis and disease: where are we now? (2025/01/22) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Brain network and energy imbalance in Parkinson's disease: linking ATP reduction and α-synuclein pathology. (2025/01/22) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Clonorchis sinensis and Echinostoma hortense detected by endoscopy and molecular characterization: two case reports and update on diagnosis. (2025/01/22) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Decoding mitochondrial DNA damage and repair associated with H. pylori infection. (2025/01/21) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Mitochondrial abnormalities as a target of intervention in acute myeloid leukemia. (2025/01/20) ♡
• Metabolic consequences of erastin-induced ferroptosis in human ovarian cancer cells: an untargeted metabolomics study. (2025/01/20) ♡
• Semaglutide alleviates pancreatic β cell function via the METTL14 signaling and modulating gut microbiota in type 2 diabetes mellitus mice. (2025/01/15) ♡
• Iron improves the antiviral activity of NK cells. (2025/01/14) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Gualou Xiebai Banxia Decoction suppresses cardiomyocyte apoptosis in mice after myocardial infarction through activation of acetaldehyde dehydrogenase 2. (2025/01/13) ♡
• Histone deacetylase 6 inhibition prevents hypercholesterolemia-induced erectile dysfunction independent of changes in markers of autophagy. (2025/01/09) ♡
• Protective effects of Cordyceps militaris against hepatocyte apoptosis and liver fibrosis induced by high palmitic acid diet. (2025/01/09) ♡
• Elucidating the mechanism of action of astragalus polysaccharide on ionizing radiation-induced myocardial damage based on network pharmacology and experimental research. (2025/01/03) ♡
• The isoflavone puerarin promotes generation of human iPSC-derived pre-oligodendrocytes and enhances endogenous remyelination in rodent models. (2025/01/01) ♡
• Isorhamnetin ameliorates dopaminergic neuronal damage by targeting FOSL1 to activate Akt/mTOR in 6-OHDA-induced SH-SY5Y cells. (2025/01/01) ♡
• Matrine relieved DHAV-1-induced hepatocyte excessive interferon and pyroptosis by activating mitophagy. (2025/01/01) ♡
• Kechuan Decoction mitigates apoptosis of airway epithelial cells by improving lipid metabolism disorders and mitochondria dysfunction in HDM-induced asthma. (2025/01/01) ♡

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