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Primary lateral sclerosis

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Search Period All yearsLast 12 monthsLast 5 years Topic All topicsGeneralNutrition and dietAlternative treatment methods Type of research Any type of researchHighest evidence only (123)Meta-analysis (29)Treatment guideline (6)Systematic review (51)Randomized controlled trial (19)Phase 3 study (18)Clinical trial (658)Review article (336)Early-stage study (phase 1 or 2) (13)Laboratory or animal research (123)Case description (120)Commentary or editorial (46)Retracted publication (1) Studies currently recruiting participants only (31)

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Publications and studies (2508)

• Widespread tissue hypoxia dysregulates cell and metabolic pathways in SMA. (2020/09/01) ♡
• Glut1 Deficiency Syndrome (Glut1DS): State of the art in 2020 and recommendations of the international Glut1DS study group. (2020/08/13) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Renal pathology in a mouse model of severe Spinal Muscular Atrophy is associated with downregulation of Glial Cell-Line Derived Neurotrophic Factor (GDNF). (2020/08/11) ♡
• [Analysis of genetic variant in a child with concomitant spinal muscular atrophy and Citrin protein deficiency]. (2020/08/10) ♡
• Baicalein Attenuates Neuroinflammation by Inhibiting NLRP3/caspase-1/GSDMD Pathway in MPTP Induced Mice Model of Parkinson's Disease. (2020/08/06) ♡
• Dietary Amino Acids Impact LRRK2-Induced Neurodegeneration in Parkinson's Disease Models. (2020/08/05) ♡
• Systematic reviewiAll research on one question is searched according to fixed rules and compared side by side, so that no studies with poor outcomes are missed. Interventions to promote oral nutritional behaviours in people living with neurodegenerative disorders of the motor system: A systematic review. (2020/08/01) ♡
• ALSUntangled 53: Carnitine supplements. (2020/08/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Primary lateral sclerosis: diagnosis and management. (2020/08/01) ♡
• Amyotrophic lateral sclerosis care and research in the United States during the COVID-19 pandemic: Challenges and opportunities. (2020/08/01) ♡
• The role of managed care professionals in improving care for patients with ALS. (2020/08/01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Quality of life in children and adolescents with Spinal Muscular Atrophy. (2020/08/01) ♡
• A comparative study of South African and Portuguese amyotrophic lateral sclerosis cohorts. (2020/07/15) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Minimal weight loss related to a short fasting period causes superior mesenteric artery syndrome in a patient with amyotrophic lateral sclerosis: A case report. (2020/07/02) ♡
• Systematic reviewiAll research on one question is searched according to fixed rules and compared side by side, so that no studies with poor outcomes are missed. The role of gut microbiota, butyrate and proton pump inhibitors in amyotrophic lateral sclerosis: a systematic review. (2020/07/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Synaptic Nuclear Envelope Protein 1 (SYNE 1) Ataxia with Amyotrophic Lateral Sclerosis-like Presentation: A Novel Synaptic Nuclear Envelope Protein 1 (SYNE 1) Gene Deletion Mutation from India. (2020/07/01) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Hypoglycaemia in patients with type 1 SMA: an underdiagnosed problem? (2020/07/01) ♡
• Living near waterbodies as a proxy of cyanobacteria exposure and risk of amyotrophic lateral sclerosis: a population based case-control study. (2020/07/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Common mutations of interest in the diagnosis of amyotrophic lateral sclerosis: how common are common mutations in ALS genes? (2020/07/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. [Fatherhood achieved in a case of nonobstructive azoospermia with Kennedy's disease via microdissection testicular sperm extraction and ICSI: A case report and literature review]. (2020/07/01) ♡
• Living with motor neurone disease: an insider's sociological perspective. (2020/07/01) ♡
• X-ray phase contrast tomography for the investigation of amyotrophic lateral sclerosis. (2020/07/01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Effects of nusinersen after one year of treatment in 123 children with SMA type 1 or 2: a French real-life observational study. (2020/06/12) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Multidisciplinary care in amyotrophic lateral sclerosis: a 4-year longitudinal observational study. (2020/06/09) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. The ultrasonography: another weapon to counter the amyotrophic lateral sclerosis. (2020/06/01) ♡
• Effect of home-based Tai Chi, Yoga or conventional balance exercise on functional balance and mobility among persons with idiopathic Parkinson's disease: An experimental study. (2020/06/01) ♡
• [Connotation of ancient "stroke" and Qianyin Yaofang Xiaoxuming Decoction treating cerebral infarction and cerebral hemorrhage]. (2020/06/01) ♡
• [Experience of treating facial neuritis, unexplained limb weakness, cervical spondylosis, acute myelitis, acute radiculitis, Guillain Barre syndrome, multiple sclerosis, myasthenia gravis, motor neuron disease, dermatomyositis with Xiaoxuming Decoction]. (2020/06/01) ♡
• Energy Balance as a Moderator of Neurologic Disease Risk and Progression. (2020/06/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. [Stress induced ketoacidosis in spinal muscular atrophy. Report of one case]. (2020/06/01) ♡
• The study of levels from redox-active elements in cerebrospinal fluid of amyotrophic lateral sclerosis patients carrying disease-related gene mutations shows potential copper dyshomeostasis. (2020/05/27) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Neuro-Cells therapy improves motor outcomes and suppresses inflammation during experimental syndrome of amyotrophic lateral sclerosis in mice. (2020/05/01) ♡
• Systematic reviewiAll research on one question is searched according to fixed rules and compared side by side, so that no studies with poor outcomes are missed. The current use of telehealth in ALS care and the barriers to and facilitators of implementation: a systematic review. (2020/05/01) ♡
• ALS clinical research learning institutes (ALS-CRLI): empowering people with ALS to be research ambassadors. (2020/05/01) ♡
• Development of behenic acid-ethyl cellulose oleogel stabilized Pickering emulsions as low calorie fat replacer. (2020/05/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. The effects of statins on microglial cells to protect against neurodegenerative disorders: A mechanistic review. (2020/05/01) ♡
• Biochemical parameters in determination of nutritional status in amyotrophic lateral sclerosis. (2020/05/01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Predictive energy equations for spinal muscular atrophy type I children. (2020/05/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. The effects of diet and sex in amyotrophic lateral sclerosis. (2020/05/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. ALSUntangled No. 54: "LEAP2BFIT". (2020/05/01) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice. (2020/04/30) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. [Severe ketoacidosis induced by short-term starvation in a patient with spinal muscular atrophy]. (2020/04/24) ♡
• Environmental and Occupational Risk Factors of Amyotrophic Lateral Sclerosis: A Population-Based Case-Control Study. (2020/04/22) ♡
• The French national protocol for Kennedy's disease (SBMA): consensus diagnostic and management recommendations. (2020/04/10) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. A clinicopathological study of ALS with L126S mutation in the SOD1 gene presenting with isolated inferior olivary hypertrophy. (2020/04/01) ♡
• Soluble iron accumulation induces microglial glutamate release in the spinal cord of sporadic amyotrophic lateral sclerosis. (2020/04/01) ♡
• Diffusion tensor imaging evidence of corticospinal pathway involvement in frontotemporal lobar degeneration. (2020/04/01) ♡
• Early focality and spread of cortical dysfunction in amyotrophic lateral sclerosis: A regional study across the motor cortices. (2020/04/01) ♡
• Polysomnography findings in pediatric spinal muscular atrophy types 1-3. (2020/04/01) ♡
• Systematic reviewiAll research on one question is searched according to fixed rules and compared side by side, so that no studies with poor outcomes are missed. The evolving role of surface electromyography in amyotrophic lateral sclerosis: A systematic review. (2020/04/01) ♡

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