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Primary lateral sclerosis

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Search Period All yearsLast 12 monthsLast 5 years Topic All topicsGeneralNutrition and dietAlternative treatment methods Type of research Any type of researchHighest evidence only (123)Meta-analysis (29)Treatment guideline (6)Systematic review (51)Randomized controlled trial (19)Phase 3 study (18)Clinical trial (658)Review article (336)Early-stage study (phase 1 or 2) (13)Laboratory or animal research (123)Case description (120)Commentary or editorial (46)Retracted publication (1) Studies currently recruiting participants only (31)

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Publications and studies (2508)

• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Malnutrition at diagnosis in amyotrophic lateral sclerosis (ALS) and its influence on survival: Using GLIM criteria. (2021/01/01) ♡
• Metal(loid)s role in the pathogenesis of amyotrophic lateral sclerosis: Environmental, epidemiological, and genetic data. (2021/01/01) ♡
• Blood Metal Levels and Amyotrophic Lateral Sclerosis Risk: A Prospective Cohort. (2021/01/01) ♡
• Peripheral inflammation preceeding ischemia impairs neuronal survival through mechanisms involving miR-127 in aged animals. (2021/01/01) ♡
• Longitudinal clinical and neuroanatomical correlates of memory impairment in motor neuron disease. (2021/01/01) ♡
• Deregulation of phosphatidylinositol-4-phosphate in the development of amyotrophic lateral sclerosis 8. (2021/01/01) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Response to letter: A decision for life - Treatment decisions in newly diagnosed families with spinal muscular atrophy. (2021/01/01) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Probiotic Clostridium butyricum ameliorated motor deficits in a mouse model of Parkinson's disease via gut microbiota-GLP-1 pathway. (2021/01/01) ♡
• SMN Depleted Mice Offer a Robust and Rapid Onset Model of Nonalcoholic Fatty Liver Disease. (2021/01/01) ♡
• Nusinersen treatment of Spinal Muscular Atrophy Type 1 - results of expanded access programme in Poland. (2021/01/01) ♡
• Treatment guidelineiAn official agreement between doctors about how this disease should be treated. This is not a single study but the conclusion of an entire medical field. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)(1). (2021/01/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Effects of vitamin E on neurodegenerative diseases: an update. (2021/01/01) ♡
• Contradictory Responses to the COVID-19 Pandemic in Amyotrophic Lateral Sclerosis Patients and Their Families and Caregivers in Japan. (2021/01/01) ♡
• Use of a new ALS specific respiratory questionnaire: the ARES score. (2021/01/01) ♡
• Factors associated with Noninvasive ventilation compliance in patients with ALS/MND. (2021/01/01) ♡
• Factors Affecting Energy Metabolism and Prognosis in Patients with Amyotrophic Lateral Sclerosis. (2021/01/01) ♡
• The Importance of Diagnostic and Prognostic Biomarker Identification and Classification Towards Understanding ALS Pathogenesis. (2021/01/01) ♡
• Photo-Oxygenation: An Innovative New Therapeutic Approach Against Amyloidoses. (2021/01/01) ♡
• Pathological manifestation of human endogenous retrovirus K in frontotemporal dementia. (2021/01/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Mixed pathologies mimicking motor neuron disease: a case report and review of the literature. (2021/01/01) ♡
• Inflammatory Cytokine Levels in Patients with Sporadic Amyotrophic Lateral Sclerosis. (2021/01/01) ♡
• Continuous lengthening potential after four years of magnetically controlled spinal deformity correction in children with spinal muscular atrophy. (2020/12/30) ♡
• Advances in genetics research in the pathogenesis of amyotrophic lateral sclerosis. (2020/12/28) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Circulating microRNAs as potential biomarkers and therapeutic targets in spinal muscular atrophy. (2020/12/25) ♡
• Lack of astrocytes hinders parenchymal oligodendrocyte precursor cells from reaching a myelinating state in osmolyte-induced demyelination. (2020/12/24) ♡
• TDP-43-specific Autoantibody Decline in Patients With Amyotrophic Lateral Sclerosis. (2020/12/24) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Pretreatment Effect of Inflammatory Stimuli and Characteristics of Tryptophan Transport on Brain Capillary Endothelial (TR-BBB) and Motor Neuron Like (NSC-34) Cell Lines. (2020/12/24) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. How to Build and to Protect the Neuromuscular Junction: The Role of the Glial Cell Line-Derived Neurotrophic Factor. (2020/12/24) ♡
• LSM12-EPAC1 defines a neuroprotective pathway that sustains the nucleocytoplasmic RAN gradient. (2020/12/23) ♡
• Cognitive Performance of Patients with Adult 5q-Spinal Muscular Atrophy and with Amyotrophic Lateral Sclerosis. (2020/12/23) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Case Report: Association of a Variant of Unknown Significance in the FIG4 Gene With Frontotemporal Dementia and Slowly Progressing Motoneuron Disease: A Case Report Depicting Common Challenges in Clinical and Genetic Diagnostics of Rare Neuropsychiatric and Neurologic Disorders. (2020/12/22) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Rare cause of unilateral upper limb weakness in a young adolescent. (2020/12/21) ♡
• Poor Bone Quality in Patients With Amyotrophic Lateral Sclerosis. (2020/12/18) ♡
• Wildtype σ1 receptor and the receptor agonist improve ALS-associated mutation-induced insolubility and toxicity. (2020/12/18) ♡
• AggreCount: an unbiased image analysis tool for identifying and quantifying cellular aggregates in a spatially defined manner. (2020/12/18) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Mixed Upper and Lower Motor Neuron Damage in Japanese Encephalitis Virus Infection. (2020/12/18) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. C9orf72 Frontotemporal Dementia and/or Amyotrophic Lateral Sclerosis. (2020/12/17) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Metabolic and Nutritional Issues Associated with Spinal Muscular Atrophy. (2020/12/16) ♡
• Regeneration of Functional Neurons After Spinal Cord Injury via in situ NeuroD1-Mediated Astrocyte-to-Neuron Conversion. (2020/12/16) ♡
• Systematic reviewiAll research on one question is searched according to fixed rules and compared side by side, so that no studies with poor outcomes are missed. Palmitoylethanolamide: A Nutritional Approach to Keep Neuroinflammation within Physiological Boundaries-A Systematic Review. (2020/12/15) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. The Benefit of Non-invasive Ventilation in Motor Neuron Disease. (2020/12/15) ♡
• Skeletal Muscle-Restricted Expression of Human SOD1 in Transgenic Mice Causes a Fatal ALS-Like Syndrome. (2020/12/14) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. The Convergence of Alpha-Synuclein, Mitochondrial, and Lysosomal Pathways in Vulnerability of Midbrain Dopaminergic Neurons in Parkinson's Disease. (2020/12/14) ♡
• Correlational Analysis of ALS Progression and Serum NfL Measured by Simoa Assay in Chinese Patients. (2020/12/03) ♡
• Genomic Portrait of a Sporadic Amyotrophic Lateral Sclerosis Case in a Large Spinocerebellar Ataxia Type 1 Family. (2020/12/02) ♡
• Neuromuscular manifestations of lead poisoning in opium and herbal users in Iran. (2020/12/01) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Infantile spinal muscular atrophy (SMA). (2020/12/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Spinal muscular atrophy (SMA) type I (Werdnig-Hoffmann disease). (2020/12/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Clinical features of spinal muscular atrophy (SMA) type 2. (2020/12/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Clinical features of spinal muscular atrophy (SMA) type 3 (Kugelberg-Welander disease). (2020/12/01) ♡

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