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Alpha-1 antitrypsin deficiency

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Search Period All yearsLast 12 monthsLast 5 years Topic All topicsGeneralNutrition and dietAlternative treatment methods Type of research Any type of researchHighest Level of Evidence Only (35)Meta-analysis (8)Treatment guideline (5)Phase 3 study (8)Randomized trial (8)Systematic review (6)Clinical Trial (169)Review article (176)Early study (phase 1 or 2) (18)Case report (114)Laboratory or animal study (26)Commentary or editorial (90)Retracted publication (1) Only studies currently recruiting participants (28)

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Publications and studies (1172)

• One-year Prevalence, Comorbidities, and Cost of Hospitalizations for Alpha-1 Antitrypsin Deficiency among Patients with Chronic Obstructive Pulmonary Disease in the United States. (2017/07/21) ♡
• Serum Proteins Associated with Emphysema Progression in Severe Alpha-1 Antitrypsin Deficiency. (2017/07/15) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Clinical utility of alpha-1 proteinase inhibitor in the management of adult patients with severe alpha-1 antitrypsin deficiency: a review of the current literature. (2017/07/14) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. The pathological Trento variant of alpha-1-antitrypsin (E75V) shows nonclassical behaviour during polymerization. (2017/07/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Alpha-1-antitrypsin deficiency-related panniculitis: two cases with diverse clinical courses. (2017/07/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Alpha-1-antitrypsin deficiency: Genetic variations, clinical manifestations and therapeutic interventions. (2017/07/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. The Role of Diagnosis and Treatment of Underlying Liver Disease for the Prognosis of Primary Liver Cancer. (2017/07/01) ♡
• ERAD defects and the HFE-H63D variant are associated with increased risk of liver damages in Alpha 1-Antitrypsin Deficiency. (2017/06/15) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Alpha-1 antitrypsin Pi*SZ genotype: estimated prevalence and number of SZ subjects worldwide. (2017/06/08) ♡
• Autophagy in Hepatocytes in Infants With Alpha-1 ATD and Different Liver Disease Outcomes: A Retrospective Analysis. (2017/06/01) ♡
• Selenium status and fungi in the protein-losing enteropathy of persistent diarrhea. (2017/06/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Long-term clinical outcomes following treatment with alpha 1-proteinase inhibitor for COPD associated with alpha-1 antitrypsin deficiency: a look at the evidence. (2017/05/30) ♡
• Deterioration of quality of life is associated with the exacerbation frequency in individuals with alpha-1-antitrypsin deficiency - analysis from the German Registry. (2017/05/12) ♡
• Exogenous alpha 1-antitrypsin down-regulates SERPINA1 expression. (2017/05/09) ♡
• Meta-analysisiAll studies on one question combined and calculated together. This is the strongest form of research that exists: a single loose study can be coincidence, dozens together much less so. The label says something about the design, not about the outcome — which can also be that something does NOT work. Treatment of lung disease in alpha-1 antitrypsin deficiency: a systematic review. (2017/05/02) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Liver Transplantation in Alpha-1 Antitrypsin Deficiency. (2017/05/01) ♡
• Emerging Concepts and Human Trials in Alpha-1-Antitrypsin Deficiency Liver Disease. (2017/05/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Intraoperative Aortic Dissection during Lung Transplantation in a Patient with Alpha-1 Antitrypsin Deficiency. (2017/05/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. The first report of two cases of fatal liver injury due to anti-tuberculosis drugs in the presence of alpha-1 antitrypsin deficiency. (2017/04/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. A Challenging Case of Severe Infantile Cholestasis in Alpha-1 Antitrypsin Deficiency. (2017/03/01) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Bile Duct Ligation Induces ATZ Globule Clearance in a Mouse Model of α-1 Antitrypsin Deficiency. (2017/02/10) ♡
• Immunohistochemical Analysis of the Stem Cell Marker LGR5 in Pediatric Liver Disease. (2017/01/01) ♡
• Pushing the boundaries in liver graft utilisation in transplantation: Case report of a donor with previous bile duct injury repair. (2017/01/01) ♡
• Pathophysiology of Alpha-1 Antitrypsin Deficiency Liver Disease. (2017/01/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Pathophysiology of Alpha-1 Antitrypsin Lung Disease. (2017/01/01) ♡
• Measuring and Interpreting Serum AAT Concentration. (2017/01/01) ♡
• Laboratory Diagnosis by Genotyping. (2017/01/01) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Genotyping Protocol for the Alpha-1 Antitrypsin (PiZ) Mouse Model. (2017/01/01) ♡
• Practical Methods for Assessing Emphysema Severity Based on Estimation of Linear Mean Intercept (Lm) in the Context of Animal Models of Alpha-1 Antitrypsin Deficiency. (2017/01/01) ♡
• Knockdown of Z Mutant Alpha-1 Antitrypsin In Vivo Using Modified DNA Antisense Oligonucleotides. (2017/01/01) ♡
• Immunohistochemistry Staining for Human Alpha-1 Antitrypsin. (2017/01/01) ♡
• Periodic Acid-Schiff Staining with Diastase. (2017/01/01) ♡
• Protocol for Directed Differentiation of Human Induced Pluripotent Stem Cells (iPSCs) to a Hepatic Lineage. (2017/01/01) ♡
• Measuring the Effect of Histone Deacetylase Inhibitors (HDACi) on the Secretion and Activity of Alpha-1 Antitrypsin. (2017/01/01) ♡
• Quantification of Z-AAT by a Z-Specific "Sandwich" ELISA. (2017/01/01) ♡
• Semiquantitation of Monomer and Polymer Alpha-1 Antitrypsin by Centrifugal Separation and Assay by Western Blot of Soluble and Insoluble Components. (2017/01/01) ♡
• Electrophoresis- and FRET-Based Measures of Serpin Polymerization. (2017/01/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Therapeutics: Alpha-1 Antitrypsin Augmentation Therapy. (2017/01/01) ♡
• Therapeutic Options in Alpha-1 Antitrypsin Deficiency: Liver Transplantation. (2017/01/01) ♡
• Therapeutics: Gene Therapy for Alpha-1 Antitrypsin Deficiency. (2017/01/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Should Serum Protein Electrophoresis Be a Surrogate for Liver Biopsy in Some Cases of Alpha(1) Antitrypsin Deficiency? (2017/01/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Epidemiology of Rare Lung Diseases: The Challenges and Opportunities to Improve Research and Knowledge. (2017/01/01) ♡
• Pulmonary langerhans cell histiocytosis - insight into the incidence of alfa-1-antitrypsin (A1ATD) deficiency alleles. (2017/01/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Successful Outcome and Biliary Drainage in an Infant with Concurrent Alpha-1-Antitrypsin Deficiency and Biliary Atresia. (2017/01/01) ♡
• Living with a Rare Health Condition: The Influence of a Support Community and Public Stigma on Communication, Stress, and Available Support. (2017/01/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Liver Disease in Alpha-1 Antitrypsin Deficiency: Current Approaches and Future Directions. (2017/01/01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Inhaled A1AT in Adult Stable Bronchiectasis (2017-12-27) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Identification of Genes Associated With Lung Disease in Patients With Rheumatoid Arthritis (2017-07-02) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Liver Disease in Patients With alpha1-antitrypsin Deficiency (2017-05-31) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Lung Volume Reduction Coils for Emphysema in Alpha-1 Antitrypsin Deficiency (2017-05-02) ♡

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