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Alpha-1 antitrypsin deficiency

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Search Period All yearsLast 12 monthsLast 5 years Topic All topicsGeneralNutrition and dietAlternative treatment methods Type of research Any type of researchHighest Level of Evidence Only (35)Meta-analysis (8)Treatment guideline (5)Phase 3 study (8)Randomized trial (8)Systematic review (6)Clinical Trial (169)Review article (176)Early study (phase 1 or 2) (18)Case report (114)Laboratory or animal study (26)Commentary or editorial (90)Retracted publication (1) Only studies currently recruiting participants (28)

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Publications and studies (1172)

• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Study Comparing Weekly Intravenous Administration of OctaAlpha1 With a Marketed Preparation Glassia® in Subjects With Alpha-1-antitrypsin Deficiency (2018-04-10) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. The Effects of Discontinuation of Vitamin K Antagonists on the Rate of Elastin Degradation (2018-01-25) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. The Use of High Resolution Chest Computed Tomography in Alpha-1 Antitrypsin Deficiency (2018-01-23) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Alpha 1 Antitrypsin Deficiency, Two Cases of Heterozygous S and Clayton Null Alleles. (2017/12/19) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Nuclease-Mediated Gene Therapies for Inherited Metabolic Diseases of the Liver. (2017/12/19) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Small Cell Lung Cancer. Methodology and Preliminary Results of the SMALL CELL Study. (2017/12/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Alpha-1-Antitrypsin Deficiency Associated With Null Alleles. (2017/12/01) ♡
• Randomized researchiParticipants were divided into groups by lottery and compared with each other. This reduces the chance that a difference is due to something other than the treatment. Bioequivalence of a Liquid Formulation of Alpha(1)-Proteinase Inhibitor Compared with Prolastin®-C (Lyophilized Alpha(1)-PI) in Alpha(1)-Antitrypsin Deficiency. (2017/12/01) ♡
• A1AT polymorphisms may be associated with clinical characteristics of retrovirus infections in a mixed ethnic population from the Brazilian Amazon region. (2017/12/01) ♡
• Smoking-Related Interstitial Fibrosis: Evidence of Radiologic Regression with Advancing Age and Smoking Cessation. (2017/12/01) ♡
• Mildly Elevated Liver Transaminase Levels: Causes and Evaluation. (2017/12/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. European Respiratory Society statement: diagnosis and treatment of pulmonary disease in α(1)-antitrypsin deficiency. (2017/11/30) ♡
• Gene and miRNA expression profiles in PBMCs from patients with severe and mild emphysema and PiZZ alpha1-antitrypsin deficiency. (2017/11/29) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Diagnosing alpha-1 antitrypsin deficiency: the first step in precision medicine. (2017/11/27) ♡
• An RNA structure-mediated, posttranscriptional model of human α-1-antitrypsin expression. (2017/11/21) ♡
• Screening for Chronic Obstructive Pulmonary Disease. (2017/11/07) ♡
• Lung transplantation and survival outcomes in patients with oxygen-dependent COPD with regard to their alpha-1 antitrypsin deficiency status. (2017/11/07) ♡
• Pulmonary (3)He Magnetic Resonance Imaging Biomarkers of Regional Airspace Enlargement in Alpha-1 Antitrypsin Deficiency. (2017/11/01) ♡
• Quantitative disease progression model of α-1 proteinase inhibitor therapy on computed tomography lung density in patients with α-1 antitrypsin deficiency. (2017/11/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. A Rare Phenotype of Alpha-1-Antitrypsin Deficiency Owing to PI*IS in a Newborn With Liver Disease. (2017/11/01) ♡
• Biochemical comparison of four commercially available human α(1)-proteinase inhibitors for treatment of α(1)-antitrypsin deficiency. (2017/11/01) ♡
• SERPINA1 and MAN1B1 polymorphisms are not linked to severe liver disease in a French cohort of alpha-1 antitrypsin deficiency children. (2017/11/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. The important role of primary care providers in the detection of alpha-1 antitrypsin deficiency. (2017/11/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Genetic Testing in Liver Disease: What to Order, in Whom, and When. (2017/11/01) ♡
• Survival Advantage of Both Human Hepatocyte Xenografts and Genome-Edited Hepatocytes for Treatment of α-1 Antitrypsin Deficiency. (2017/11/01) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Chronic Obstructive Pulmonary Disease (COPD): "Not a Cigarette Only Pulmonary Disease". (2017/11/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. COPD in individuals with the PiMZ alpha-1 antitrypsin genotype. (2017/10/25) ♡
• Case-finding for alpha1-antitrypsin deficiency in Kazakh patients with COPD. (2017/10/25) ♡
• Alpha-1 antitrypsin augmentation therapy decreases miR-199a-5p, miR-598 and miR-320a expression in monocytes via inhibition of NFκB. (2017/10/23) ♡
• Oncostatin M and TNF-α Induce Alpha-1 Antitrypsin Production in Undifferentiated Adipose Stromal Cells. (2017/10/15) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Risk of cancer after lung transplantation for COPD. (2017/10/03) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. A New SERPINA-1 Missense Mutation Associated with Alpha-1 Antitrypsin Deficiency and Bronchiectasis. (2017/10/01) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Genetically engineered cell lines for α1-antitrypsin expression. (2017/10/01) ♡
• Identification of a new defective SERPINA1 allele (PI*Z(la palma)) encoding an alpha-1-antitrypsin with altered glycosylation pattern. (2017/10/01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. The prevalence of PI*S and PI*Z SERPINA1 alleles in healthy individuals and COPD patients in Saudi Arabia: A case-control study. (2017/10/01) ♡
• Vitamin K deficit and elastolysis theory in pulmonary elasto-degenerative diseases. (2017/10/01) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Alpha-1 antitrypsin deficiency associated to the variant PI*Mpalermo: Analysis of 8 cases. (2017/09/20) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Cardiovascular risk in patients with alpha-1-antitrypsin deficiency. (2017/09/15) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Impact of alpha 1-antitrypsin deficiency and prior augmentation therapy on patients' survival after lung transplantation. (2017/09/10) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Survival in individuals with severe alpha 1-antitrypsin deficiency (PiZZ) in comparison to a general population with known smoking habits. (2017/09/09) ♡
• Genome-wide analysis of health-related biomarkers in the UK Household Longitudinal Study reveals novel associations. (2017/09/08) ♡
• [Alpha-2 Macroglobulin Serum Level in Patients with Alpha-1 Antitrypsin Deficiency]. (2017/09/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. [A Rare Cause of a Spontaneous Pneumothorax]. (2017/09/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Epidermal Cyst in the Breast: A Diagnostic Dilemma. (2017/09/01) ♡
• Intensive smoking diminishes the differences in quality of life and exacerbation frequency between the alpha-1-antitrypsin deficiency genotypes PiZZ and PiSZ. (2017/09/01) ♡
• Comparison of exercise training responses in COPD patients with and without Alpha-1 antitrypsin deficiency. (2017/09/01) ♡
• Artificial DnaJ Protein for protein production and conformational diseases. (2017/08/17) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Supraclavicular aneurysm as a presentation of alpha-1 antitrypsin deficiency. (2017/08/02) ♡
• Exacerbations and duration of smoking abstinence are associated with the annual loss of FEV(1) in individuals with PiZZ alpha-1-antitrypsin deficiency. (2017/08/01) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Improving adherence to alpha-1 antitrypsin deficiency screening guidelines using the pulmonary function laboratory. (2017/07/31) ♡

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