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ALS (amyotrophic lateral sclerosis)

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Search Period All yearsLast 12 monthsLast 5 years Topic All topicsGeneralNutrition and dietAlternative treatment methods Type of research Any type of researchOnly the strongest evidence (98)Meta-analysis (26)Treatment guideline (4)Systematic review (40)Phase 3 study (14)Randomized trial (14)Clinical trial (627)Review article (532)Early study (phase 1 or 2) (11)Single patient description (77)Laboratory or animal research (69)Commentary or editorial (40)Retracted publication (1) Studies currently recruiting participants only (30)

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Publications and studies (2463)

• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Jaw Clonus and Limb Fasciculations. (2018/12/27) ♡
• Epidural anesthesia combined with sedation with dexmedetomidine for appendectomy in a patient with amyotrophic lateral sclerosis: a case report. (2018/12/26) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. A Novel Mutation in the Stalk Domain of KIF5A Causes a Slowly Progressive Atypical Motor Syndrome. (2018/12/22) ♡
• The Japanese Early-Stage Trial of High-Dose Methylcobalamin for Amyotrophic Lateral Sclerosis (JETALS): Protocol for a Randomized Controlled Trial. (2018/12/21) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Dynamic changes of CX3CL1/CX3CR1 axis during microglial activation and motor neuron loss in the spinal cord of ALS mouse model. (2018/12/21) ♡
• The Impact of Coffee and Caffeine on Multiple Sclerosis Compared to Other Neurodegenerative Diseases. (2018/12/21) ♡
• CSF and blood biomarkers in amyotrophic lateral sclerosis: protocol for a systematic review and meta-analysis. (2018/12/20) ♡
• β-N-methylamino-L-alanine (BMAA) suppresses cell cycle progression of non-neuronal cells. (2018/12/20) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Neuroanatomical Quantitative Proteomics Reveals Common Pathogenic Biological Routes between Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). (2018/12/20) ♡
• Analysis of spinal and muscle pathology in transgenic mice overexpressing wild-type and ALS-linked mutant MATR3. (2018/12/19) ♡
• The clinical assessment of amyotrophic lateral sclerosis patients' prognosis by ZNF512B gene, neck flexor muscle power score and body mass index (BMI). (2018/12/19) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Metabolomics Biomarkers: A Strategy Toward Therapeutics Improvement in ALS. (2018/12/18) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. A near miss: Autonomic dysfunction in a 2% total burn surface area burn patient with ventilator-dependent amyotrophic lateral sclerosis. (2018/12/18) ♡
• Randomized researchiParticipants were divided into groups by lottery and compared with each other. This reduces the chance that a difference is due to something other than the treatment. Efficacy of different interaction devices using non-immersive virtual tasks in individuals with Amyotrophic Lateral Sclerosis: a cross-sectional randomized trial. (2018/12/17) ♡
• Astrocyte-Mediated Neuromodulatory Regulation in Preclinical ALS: A Metadata Analysis. (2018/12/17) ♡
• Properties of LINE-1 proteins and repeat element expression in the context of amyotrophic lateral sclerosis. (2018/12/15) ♡
• CSF Neurofilament Light Chain Levels in Primary Progressive MS: Signs of Axonal Neurodegeneration. (2018/12/14) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Transcriptomic Analysis of Zebrafish TDP-43 Transgenic Lines. (2018/12/13) ♡
• Distinct Incidence of Takotsubo Syndrome Between Amyotrophic Lateral Sclerosis and Synucleinopathies: A Cohort Study. (2018/12/13) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Yeast Models of Prion-Like Proteins That Cause Amyotrophic Lateral Sclerosis Reveal Pathogenic Mechanisms. (2018/12/11) ♡
• Cyanobacterial Neurotoxin Beta-Methyl-Amino-l-Alanine Affects Dopaminergic Neurons in Optic Ganglia and Brain of Daphnia magna. (2018/12/08) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. KIF5A and ALS2 Variants in a Family With Hereditary Spastic Paraplegia and Amyotrophic Lateral Sclerosis. (2018/12/07) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Amyotrophic Lateral Sclerosis and its Mimics/Variants: A Comprehensive Review. (2018/12/06) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Kinase-Based Taming of Brain Microglia Toward Disease-Modifying Therapy. (2018/12/05) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Biomarkers for Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Associated With Hexanucleotide Expansion Mutations in C9orf72. (2018/12/05) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Developing a Neuroimaging Biomarker for Amyotrophic Lateral Sclerosis: Multi-Center Data Sharing and the Road to a "Global Cohort". (2018/12/04) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Emerging Magnetic Resonance Imaging Techniques and Analysis Methods in Amyotrophic Lateral Sclerosis. (2018/12/04) ♡
• Prognostic Nomogram Associated with Longer Survival in Amyotrophic Lateral Sclerosis Patients. (2018/12/04) ♡
• Death Anxiety and Depression in Amyotrophic Lateral Sclerosis Patients and Their Primary Caregivers. (2018/12/03) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. A novel VRK1 mutation associated with recessive distal hereditary motor neuropathy. (2018/12/03) ♡
• Lingual and Jaw Kinematic Abnormalities Precede Speech and Swallowing Impairments in ALS. (2018/12/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Environmental Selenium and Human Health: an Update. (2018/12/01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Serum irisin is upregulated in patients affected by amyotrophic lateral sclerosis and correlates with functional and metabolic status. (2018/12/01) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Editorial. (2018/12/01) ♡
• A De Novo RAPGEF2 Variant Identified in a Sporadic Amyotrophic Lateral Sclerosis Patient Impairs Microtubule Stability and Axonal Mitochondria Distribution. (2018/12/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Respiratory muscle testing in amyotrophic lateral sclerosis: a practical approach. (2018/12/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Rab-dependent cellular trafficking and amyotrophic lateral sclerosis. (2018/12/01) ♡
• An emerging role of dysfunctional axon-oligodendrocyte coupling in neurodegenerative diseases. (2018/12/01) ♡
• Gene-Environment-Time Interactions in Neurodegenerative Diseases: Hypotheses and Research Approaches. (2018/12/01) ♡
• Clustering, Pathway Enrichment, and Protein-Protein Interaction Analysis of Gene Expression in Neurodevelopmental Disorders. (2018/11/27) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Motor and Nonmotor Symptoms of Parkinson's Disease: Antagonistic Pleiotropy Phenomena Derived from α-Synuclein Evolvability? (2018/11/22) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Utility of threshold tracking transcranial magnetic stimulation in ALS. (2018/11/17) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Traditional Korean Medicine Treatment for Patients with Wilting Disorder: A Literature Review of In Vivo Studies. (2018/11/13) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Pathogenic commonalities between spinal muscular atrophy and amyotrophic lateral sclerosis: Converging roads to therapeutic development. (2018/11/01) ♡
• Relationship of statins and other cholesterol-lowering medications and risk of amyotrophic lateral sclerosis in the US elderly. (2018/11/01) ♡
• Pilot trial of inosine to elevate urate levels in amyotrophic lateral sclerosis. (2018/10/22) ♡
• Functional and Endoscopic Indicators for Percutaneous Endoscopic Gastrostomy (PEG) in Amyotrophic Lateral Sclerosis Patients. (2018/10/14) ♡
• Protein production is an early biomarker for RNA-targeted therapies. (2018/10/14) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. A case of amyotrophic lateral sclerosis which was diagnosed with progressive dysphagia and muscle atrophy. (2018/10/13) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. [Nutritional management of amyotrophic lateral sclerosis: summary of recommendations]. (2018/10/08) ♡

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