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ALS (amyotrophic lateral sclerosis)

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Search Period All yearsLast 12 monthsLast 5 years Topic All topicsGeneralNutrition and dietAlternative treatment methods Type of research Any type of researchOnly the heaviest evidence (99)Meta-analysis (26)Treatment guideline (4)Systematic review (40)Phase 3 Study (15)Randomized trial (14)Clinical trial (625)Review article (534)Early study (phase 1 or 2) (12)Single patient description (77)Laboratory or animal research (69)Commentary or editorial (40)Retracted publication (1) Studies currently recruiting participants only (31)

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Publications and studies (2467)

• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. A Study to Assess the Safety, Tolerability, and Pharmacokinetics of BIIB078 in Adults With C9ORF72-Associated Amyotrophic Lateral Sclerosis (2022-01-14) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Longitudinal Study of Innate Lymphoid Cells in Peripheral Blood in ALS (2022-01-12) ♡
• Defective cyclophilin A induces TDP-43 proteinopathy: implications for amyotrophic lateral sclerosis and frontotemporal dementia. (2021/12/31) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Support Needs and Interventions for Family Caregivers of Patients with Amyotrophic Lateral Sclerosis (ALS): A Narrative Review with Report of Telemedicine Experiences at the Time of COVID-19 Pandemic. (2021/12/30) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Coenzyme Q10 effects in neurological diseases. (2021/12/30) ♡
• Heterozygous DHTKD1 Variants in Two European Cohorts of Amyotrophic Lateral Sclerosis Patients. (2021/12/29) ♡
• Vitamin B12 Reduces TDP-43 Toxicity by Alleviating Oxidative Stress and Mitochondrial Dysfunction. (2021/12/29) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Mitochondria-targeted nanoparticles in treatment of neurodegenerative diseases. (2021/12/28) ♡
• Investigating the Genetic Profile of the Amyotrophic Lateral Sclerosis/Frontotemporal Dementia (ALS-FTD) Continuum in Patients of Diverse Race, Ethnicity and Ancestry. (2021/12/28) ♡
• Molecular structure of an amyloid fibril formed by FUS low-complexity domain. (2021/12/27) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Hydrogen Peroxide and Amyotrophic Lateral Sclerosis: From Biochemistry to Pathophysiology. (2021/12/27) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Mimicking Amyotrophic Lateral Sclerosis: A Case of a Spinal Dural Arteriovenous Fistula. (2021/12/27) ♡
• Morphometry and Stiffness of Red Blood Cells-Signatures of Neurodegenerative Diseases and Aging. (2021/12/25) ♡
• Overlapping Genetic Architecture Between Schizophrenia and Neurodegenerative Disorders. (2021/12/24) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Opportunities Offered by Graphene Nanoparticles for MicroRNAs Delivery for Amyotrophic Lateral Sclerosis Treatment. (2021/12/24) ♡
• A Deletion of the Nuclear Localization Signal Domain in the Fus Protein Induces Stable Post-stress Cytoplasmic Inclusions in SH-SY5Y Cells. (2021/12/23) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Proteinopathies as Hallmarks of Impaired Gene Expression, Proteostasis and Mitochondrial Function in Amyotrophic Lateral Sclerosis. (2021/12/23) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. MiR-155: An Important Regulator of Neuroinflammation. (2021/12/22) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Current Drug Repurposing Strategies for Rare Neurodegenerative Disorders. (2021/12/21) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Coenzyme Q10, Ageing and the Nervous System: An Overview. (2021/12/21) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. The NRF2-Dependent Transcriptional Regulation of Antioxidant Defense Pathways: Relevance for Cell Type-Specific Vulnerability to Neurodegeneration and Therapeutic Intervention. (2021/12/21) ♡
• Spatially Resolved Expression of Transposable Elements in Disease and Somatic Tissue with SpatialTE. (2021/12/20) ♡
• Transcriptional Analysis of Nuclear-Encoded Mitochondrial Genes in Eight Neurodegenerative Disorders: The Analysis of Seven Diseases in Reference to Friedreich's Ataxia. (2021/12/20) ♡
• Altered Metabolic Profiles of the Plasma of Patients with Amyotrophic Lateral Sclerosis. (2021/12/18) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Amyotrophic Lateral Sclerosis: A Diet Review. (2021/12/17) ♡
• Preclinical Investigation in Neuroprotective Effects of the GPR55 Ligand VCE-006.1 in Experimental Models of Parkinson's Disease and Amyotrophic Lateral Sclerosis. (2021/12/16) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. DNA Damage and Repair Deficiency in ALS/FTD-Associated Neurodegeneration: From Molecular Mechanisms to Therapeutic Implication. (2021/12/16) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Silencing of Activity During Hypoxia Improves Functional Outcomes in Motor Neuron Networks in vitro. (2021/12/16) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Diagnostic and Therapeutic Potential of Exosomes in Neurodegenerative Diseases. (2021/12/16) ♡
• Meta-analysisiAll studies on one question combined and calculated together. This is the strongest form of research that exists: a single loose study can be coincidence, dozens together much less so. The label says something about the design, not about the outcome — which can also be that something does NOT work. Causal role of high body mass index in multiple chronic diseases: a systematic review and meta-analysis of Mendelian randomization studies. (2021/12/15) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Emerging Mechanisms Underpinning Neurophysiological Impairments in C9ORF72 Repeat Expansion-Mediated Amyotrophic Lateral Sclerosis/Frontotemporal Dementia. (2021/12/15) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Neuroinflammation in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia and the Interest of Induced Pluripotent Stem Cells to Study Immune Cells Interactions With Neurons. (2021/12/14) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Structural Insights Support Targeting ASK1 Kinase for Therapeutic Interventions. (2021/12/13) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Aberrance of Zinc Metalloenzymes-Induced Human Diseases and Its Potential Mechanisms. (2021/12/13) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Immune Signaling Kinases in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). (2021/12/10) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Friend or Foe? The Varied Faces of Homeostatic Synaptic Plasticity in Neurodegenerative Disease. (2021/12/10) ♡
• Sigma-1 Receptor is a Pharmacological Target to Promote Neuroprotection in the SOD1(G93A) ALS Mice. (2021/12/10) ♡
• Systematic reviewiAll research on one question is searched according to fixed rules and compared side by side, so that no studies with poor outcomes are missed. Wearable GPS and Accelerometer Technologies for Monitoring Mobility and Physical Activity in Neurodegenerative Disorders: A Systematic Review. (2021/12/10) ♡
• Sequestosome 1 Is Part of the Interaction Network of VAPB. (2021/12/09) ♡
• Assessing Causal Relationship Between Human Blood Metabolites and Five Neurodegenerative Diseases With GWAS Summary Statistics. (2021/12/09) ♡
• The split-elbow index: A biomarker of the split elbow sign in ALS. (2021/12/09) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Characterization of Neuromuscular Junctions in Mice by Combined Confocal and Super-Resolution Microscopy. (2021/12/08) ♡
• MOBP rs616147 Polymorphism and Risk of Amyotrophic Lateral Sclerosis in a Greek Population: A Case-Control Study. (2021/12/07) ♡
• Traditional East Asian Herbal Medicine for Amyotrophic Lateral Sclerosis: A Scoping Review. (2021/12/06) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Aptamer Applications in Neuroscience. (2021/12/03) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Ataxin-2 is essential for cytoskeletal dynamics and neurodevelopment in Drosophila. (2021/12/03) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Deregulation of ncRNA in Neurodegenerative Disease: Focus on circRNA, lncRNA and miRNA in Amyotrophic Lateral Sclerosis. (2021/12/02) ♡
• The nutritional management of people living with amyotrophic lateral sclerosis: A national survey of dietitians. (2021/12/01) ♡
• Systematic reviewiAll research on one question is searched according to fixed rules and compared side by side, so that no studies with poor outcomes are missed. The clinical use of curcumin on neurological disorders: An updated systematic review of clinical trials. (2021/12/01) ♡
• Stress load and neurodegeneration after gastrostomy tube placement in amyotrophic lateral sclerosis patients. (2021/12/01) ♡

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