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Alpha-1 antitrypsin deficiency

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Search Period All yearsLast 12 monthsLast 5 years Topic All topicsGeneralNutrition and dietAlternative treatment methods Type of research Any type of researchHighest Level of Evidence Only (35)Meta-analysis (8)Treatment guideline (5)Phase 3 study (8)Randomized trial (8)Systematic review (6)Clinical Trial (169)Review article (176)Early study (phase 1 or 2) (18)Case report (114)Laboratory or animal study (26)Commentary or editorial (90)Retracted publication (1) Only studies currently recruiting participants (28)

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Publications and studies (1172)

• Physico-chemically different carbon nanomaterials may elicit similar inflammatory molecular pathways within the lungs of mice. (2025/07/06) ♡
• Clinical characteristics of AATD-related COPD patients vary with age at diagnosis: data from the EARCO international registry. (2025/07/04) ♡
• Exome-based genotype-first reverse phenotyping using structured electronic health record data identifies novel SERPINA1 variants associated with liver markers and demonstrates a dominant effect for specific variants on liver phenotype. (2025/07/01) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Further Insights into Emphysema Progression and Lung Function Decline in MZ Alpha-1 Antitrypsin Deficiency. (2025/07/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Clinical Utility of Non-Invasive Tests for Liver Fibrosis in People Living With Alpha-1 Antitrypsin Deficiency. (2025/07/01) ♡
• Biochemical Alteration in Serum Alpha-1 Antitrypsin Levels in Patients with Chronic Obstructive Pulmonary Disease. (2025/07/01) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Alpha-1 Antitrypsin Deficiency: A Potential Cause of Poor Asthma Control. (2025/07/01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Alpha-1 antitrypsin in COVID-19 patients: a dual-center screening study in Malaysia. (2025/07/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. A Mysterious Trigger for Serum Amyloid A (SAA)-Associated Amyloidosis: Insights From an Autopsy Study. (2025/06/27) ♡
• Alpha-1 Antitrypsin Deficiency-Associated panniculitis: A survey of lived experience. (2025/06/26) ♡
• Quantification of serum elastase inhibitory activity in patients with pulmonary emphysema with and without alpha-1 antitrypsin deficiency. (2025/06/05) ♡
• Alpha-1 antitrypsin modulates neutrophil phenotype and function: implications for inflammatory regulation. (2025/06/04) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Alpha-1 Antitrypsin Deficiency and Bronchial Asthma: Current Challenges. (2025/06/03) ♡
• Effect of Alpha-1 Antitrypsin Deficiency on Zinc Homeostasis Gene Regulation and Interaction with Endoplasmic Reticulum Stress Response-Associated Genes. (2025/06/02) ♡
• Thresholds for conjugated hyperbilirubinaemia and hepatobiliary scintigraphy in biliary atresia: A 12-year national follow-up. (2025/06/01) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Fazirsiran for the treatment of alpha-1 antitrypsin deficiency-associated liver disease findings from the SEQUOIA phase 2 trial. (2025/05/30) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Can Proteomics Play a Significant Role in the Identification of Biomarkers for Alpha1-Antitrypsin Deficiency? (2025/05/26) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Unmasking Pulmonary Nocardiosis in an Asthmatic Host Presenting With Chronic Cough, Pulmonary Nodularity, and Ground-Glass Opacities. (2025/05/24) ♡
• A Compact Base Editor Rescues AATD-associated Liver and Lung Disease in Mouse Models. (2025/05/09) ♡
• Amyloid precursor protein as a fibrosis marker in infants with biliary atresia. (2025/04/01) ♡
• Severe alpha-1 antitrypsin deficiency is associated with a higher risk of complications after first decompensation than other aetiologies of cirrhosis. (2025/03/20) ♡
• Reduction of Z alpha-1 antitrypsin polymers in human iPSC-hepatocytes and mice by LRRK2 inhibitors. (2025/03/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Goals of chronic obstructive pulmonary disease management: a focused review for clinicians. (2025/03/01) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Fazirsiran Unveiled: Methodological Considerations for Optimizing Treatment in Alpha-1 Antitrypsin Deficiency. (2025/03/01) ♡
• Does hypersialylation compensate the functional Alpha1-AntiTrypsin (A1AT) deficiency in all critically ill patients? (2025/03/01) ♡
• Plasma Extracellular Vesicle-derived MicroRNA Associated with Human Alpha-1 Antitrypsin Deficiency-mediated Liver Disease. (2025/02/28) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Genetic characterization of a rare case of pheochromocytoma in a pulmonary transplant patient. (2025/02/06) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Editing Approaches to Treat Alpha-1 Antitrypsin Deficiency. (2025/02/01) ♡
• Novel Lobe-based Transformer model (LobTe) to predict emphysema progression in Alpha-1 Antitrypsin Deficiency. (2025/02/01) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Regarding: Alpha-1 antitrypsin deficiency associated with increased risks of skin cancer, leukemia, and hepatic cancer: A nationwide cohort study. (2025/02/01) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Authors reply: Alpha-1 antitrypsin deficiency associated with increased risks of skin cancer, leukemia, and hepatic cancer: A nationwide cohort study. (2025/02/01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Longitudinal Evaluation of Individuals With Severe Alpha-1 Antitrypsin Deficiency (Pi∗ZZ Genotype). (2025/02/01) ♡
• Spatial covariance reveals isothiocyanate natural products adjust redox stress to restore function in alpha-1-antitrypsin deficiency. (2025/01/21) ♡
• The NE/AAT/CBG axis regulates adipose tissue glucocorticoid exposure. (2025/01/09) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Sex-Differences in Alpha-1 Antitrypsin Deficiency: Data From the EARCO Registry. (2025/01/01) ♡
• Randomized researchiParticipants were divided into groups by lottery and compared with each other. This reduces the chance that a difference is due to something other than the treatment. A High-Intensity versus Moderate-Intensity Exercise Training Programme in Alpha-1 Antitrypsin Deficiency-Related COPD (IMAC): A Randomized, Controlled Trial. (2025/01/01) ♡
• Alpha-1 Antitrypsin Inclusions Sequester GRP78 in a Bile Acid-Inducible Manner. (2025/01/01) ♡
• Early-stage study (phase 1 or 2)iEarly research in a small group, primarily aimed at safety and dosage. Whether it actually works still needs to be determined afterward. Study of ARO-AAT in Normal Adult Volunteers (2025-12-24) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Polygen Defi-Alpha: Genetic Polymorphisms Study in Children With Alpha-1 Antitrypsin Deficiency, Included in the DEFI-ALPHA Cohort (2025-12-19) ♡
• Early-stage study (phase 1 or 2)iEarly research in a small group, primarily aimed at safety and dosage. Whether it actually works still needs to be determined afterward. Safety, Tolerability and Effect of ARC-AAT Injection on Circulating and Intrahepatic Alpha-1 Antitrypsin Levels (2025-12-18) ♡
• Early-stage study (phase 1 or 2)iEarly research in a small group, primarily aimed at safety and dosage. Whether it actually works still needs to be determined afterward. A Study to Evaluate Safety, Tolerability and Pharmacokinetics of Two Different Doses of Alpha1-Proteinase Inhibitor Subcutaneous (Human) 15% in Participants With Alpha1-Antitrypsin Deficiency (2025-12-12) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. The Alpha-1 Foundation's and University of Florida's Alpha-1 Coded Testing (ACT) Study (2025-11-24) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Effect Of Pulmonary Rehabilitation in Patients With Alpha-1 Antitrypsin Deficiency (2025-11-21) ♡
• Phase 3 studyiResearch in a large group of patients, the final step before a treatment can be approved. What comes out here carries significant weight. Genetic Variation in IgG in Alpha 1 Antitrypsin Deficiency (2025-11-10) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Lung Disease and Its Affect on the Work of White Blood Cells in the Lungs (2025-11-06) ♡
• Early-stage study (phase 1 or 2)iEarly research in a small group, primarily aimed at safety and dosage. Whether it actually works still needs to be determined afterward. Safety, Tolerability and Pharmacodynamic Effect of Fazirsiran (TAK-999, ARO-AAT) (2025-11-04) ♡
• Early-stage study (phase 1 or 2)iEarly research in a small group, primarily aimed at safety and dosage. Whether it actually works still needs to be determined afterward. Study of Fazirsiran (TAK-999, ARO-AAT) in Patients With Alpha-1 Antitrypsin Deficiency Associated Liver Disease (AATD) (2025-10-15) ♡
• Phase 3 studyiResearch in a large group of patients, the final step before a treatment can be approved. What comes out here carries significant weight. An Extension Study to Learn About the Long-Term Safety of Fazirsiran and if Fazirsiran Can Help People With Alpha-1 Antitrypsin Liver Disease (2025-10-14) ♡
• Early-stage study (phase 1 or 2)iEarly research in a small group, primarily aimed at safety and dosage. Whether it actually works still needs to be determined afterward. Study of YOLT-202 in the Treatment of Alpha-1 Antitrypsin Deficiency (AATD) (2025-09-26) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Screening for Alpha-1 Antitrypsin Deficiency in Patients With Airway Obstruction (2025-09-10) ♡

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