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Alpha-1 antitrypsin deficiency

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Search Period All yearsLast 12 monthsLast 5 years Topic All topicsGeneralNutrition and dietAlternative treatment methods Type of research Any type of researchHighest Level of Evidence Only (35)Meta-analysis (8)Treatment guideline (5)Phase 3 study (8)Randomized trial (8)Systematic review (6)Clinical Trial (169)Review article (176)Early study (phase 1 or 2) (18)Case report (114)Laboratory or animal study (27)Commentary or editorial (90)Retracted publication (1) Only studies currently recruiting participants (28)

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Publications and studies (1173)

• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Limited GPA and Alpha-1 Antitrypsin Deficiency in a Pediatric Patient. (2019/05/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Pharmacogenomics of chronic obstructive pulmonary disease. (2019/05/01) ♡
• Early-onset emphysema in a large French-Canadian family: a genetic investigation. (2019/05/01) ♡
• A proteomic approach to identify novel disease biomarkers in LCAT deficiency. (2019/04/30) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Understanding the role of neutrophils in chronic inflammatory airway disease. (2019/04/26) ♡
• Modulation of calreticulin expression reveals a novel exosome-mediated mechanism of Z variant α(1)-antitrypsin disposal. (2019/04/19) ♡
• The Clinical Features of Bronchiectasis Associated with Alpha-1 Antitrypsin Deficiency, Common Variable Immunodeficiency and Primary Ciliary Dyskinesia--Results from the U.S. Bronchiectasis Research Registry. (2019/04/09) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Emphysema: looking beyond alpha-1 antitrypsin deficiency. (2019/04/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. An NP's guide to diagnosing and treating alpha-1 antitrypsin deficiency. (2019/04/01) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Rare Disease Registries: Steps Forward. (2019/04/01) ♡
• Greater survival despite increased complication rates following lung transplant for alpha-1-antitrypsin deficiency compared to chronic obstructive pulmonary disease. (2019/04/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. [Alpha-1 antitrypsin deficiency, a commonly missed cause of chronic liver disease in the adult: presentation of 9 cases with review of current literature]. (2019/04/01) ♡
• Diagnosis and management of α(1)-antitrypsin deficiency in Europe: an expert survey. (2019/03/11) ♡
• Reactive centre loop dynamics and serpin specificity. (2019/03/07) ♡
• NFκB mitigates the pathological effects of misfolded α1-antitrypsin by activating autophagy and an integrated program of proteostasis mechanisms. (2019/03/01) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Glyco-engineered CHO cell lines producing alpha-1-antitrypsin and C1 esterase inhibitor with fully humanized N-glycosylation profiles. (2019/03/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Liver damage in a patient with Gaucher's disease type 1 and alpha-1 antitrypsin deficiency: a potential epigenetic effect? (2019/03/01) ♡
• Survival in the Swedish cohort with alpha-1-antitrypsin deficiency, up to the age of 43-45 years. (2019/02/28) ♡
• Bridging from Intramuscular to Limb Perfusion Delivery of rAAV: Optimization in a Non-human Primate Study. (2019/02/02) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Double lung transplantation in an HIV-positive patient with Mycobacterium kansasii infection. (2019/02/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. An unusual case of alpha-1-antitrypsin deficiency: SZ/Z. (2019/02/01) ♡
• Assessment of liver fibrosis by transient elastography (Fibroscan(®)) in patients with A1AT deficiency. (2019/02/01) ♡
• Identifying Alpha-1 Antitrypsin Deficiency Based on Computed Tomography Evidence of Emphysema. (2019/01/28) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Hyperpolarized (3) He MRI ventilatory apparent diffusion coefficient of alpha-1 antitrypsin deficiency. (2019/01/01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Safety and pharmacokinetics of Alpha-1 MP (Prolastin(®)-C) in Japanese patients with alpha(1)-antitrypsin (AAT) deficiency. (2019/01/01) ♡
• Bone Density in Children With Chronic Liver Disease Correlates With Growth and Cholestasis. (2019/01/01) ♡
• Systematic reviewiAll research on one question is searched according to fixed rules and compared side by side, so that no studies with poor outcomes are missed. Alpha1-Antitrypsin Deficiency: Transition of Care for the Child With AAT Deficiency into Adulthood. (2019/01/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Pharmaceutical Research for Inherited Metabolic Disorders of the Liver Using Human Induced Pluripotent Stem Cell and Genome Editing Technologies. (2019/01/01) ♡
• Toward In Vivo Gene Therapy Using CRISPR. (2019/01/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. A review on proteomics analysis to reveal biological pathways and predictive proteins in sulfur mustard exposed patients: roles of inflammation and oxidative stress. (2019/01/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. The importance of effective registries in pulmonary diseases and how to optimize their output. (2019/01/01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. International Study Evaluating the Safety and Efficacy of Inhaled, Human, Alpha-1 Antitrypsin (AAT) in Alpha-1 Antitrypsin Deficient Patients With Emphysema (2019-11-29) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. AL1TER™: Alpha-1 Therapy, Evaluation, and Research Patient Registry (2019-09-23) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Environment Effect on Six-Minute Walk Test Performance (2019-08-22) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Alpha-1 Carrier Genomics Study (2019-07-22) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Effect of Double Dose of Alpha 1-antitrypsin Augmentation Therapy on Lung Inflammation. (2019-05-08) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Safety & Efficacy Study of rAAV1-CB-hAAT for Alpha-1 Antitrypsin Deficiency (2019-03-28) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Effects of Different Exercise Training Modalities in Alpha-1 Antitrypsin Deficiency Patients (2019-01-16) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. A Study of an Investigational Drug, ALN-AAT, in Healthy Adult Subjects and Patients With ZZ Type Alpha-1 Antitrypsin Deficiency Liver Disease (2019-01-07) ♡
• Clinical expression of cystic fibrosis in a large cohort of Italian siblings. (2018/12/22) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Challenges in interpreting trends in testing for α(1)-antitrypsin deficiency in COPD patients from UK primary care. (2018/12/20) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Challenges in interpreting trends in testing for α(1)-antitrypsin deficiency in COPD patients from UK primary care. (2018/12/20) ♡
• [Production of transgenic mice for alpha-1 antitrypsin deficiency disease]. (2018/12/20) ♡
• Clinical and histologic features of adults with alpha-1 antitrypsin deficiency in a non-cirrhotic cohort. (2018/12/01) ♡
• Expression, Purification, and Characterization of Recombinant Human α(1)-Antitrypsin Produced Using Silkworm-Baculovirus Expression System. (2018/12/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Acquired Donor Peanut Allergy From Lung Transplantation Resulting in Respiratory Failure: A Case Report. (2018/12/01) ♡
• Portuguese consensus document for the management of alpha-1-antitrypsin deficiency. (2018/12/01) ♡
• Virus-free and oncogene-free induced pluripotent stem cell reprogramming in cord blood and peripheral blood in patients with lung disease. (2018/12/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Targeting Chronic Obstructive Pulmonary Disease Phenotypes, Endotypes, and Biomarkers. (2018/12/01) ♡
• Comparing Patients with ZZ Versus SZ Alpha-1 Antitrypsin Deficiency: Findings from AlphaNet's Disease Management Program. (2018/11/30) ♡

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