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Alpha-1 antitrypsin deficiency

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Search Period All yearsLast 12 monthsLast 5 years Topic All topicsGeneralNutrition and dietAlternative treatment methods Type of research Any type of researchHighest Level of Evidence Only (35)Meta-analysis (8)Treatment guideline (5)Phase 3 study (8)Randomized trial (8)Systematic review (6)Clinical Trial (169)Review article (176)Early study (phase 1 or 2) (18)Case report (114)Laboratory or animal study (26)Commentary or editorial (90)Retracted publication (1) Only studies currently recruiting participants (28)

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Publications and studies (1172)

• Retrospective Study on the Association of Biomarkers With Real-world Outcomes of Omalizumab-treated Patients With Allergic Asthma. (2019/10/01) ♡
• Intestinal permeability and inflammation mediate the association between nutrient density of complementary foods and biochemical measures of micronutrient status in young children: results from the MAL-ED study. (2019/10/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Airway pharmacology: treatment options and algorithms to treat patients with chronic obstructive pulmonary disease. (2019/10/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Genetic Advances in Chronic Obstructive Pulmonary Disease. Insights from COPDGene. (2019/09/15) ♡
• Exome Sequencing Reveals Immune Genes as Susceptibility Modifiers in Individuals with α(1)-Antitrypsin Deficiency. (2019/09/11) ♡
• Systematic reviewiAll research on one question is searched according to fixed rules and compared side by side, so that no studies with poor outcomes are missed. An analysis of the degree of concordance among international guidelines regarding alpha-1 antitrypsin deficiency. (2019/09/05) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Surgery for patients with Alpha 1 Antitrypsin Deficiency: A review. (2019/09/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Pulmonary Emphysema in a Child With Alpha-1 Antitrypsin Deficiency: Evaluation of 2 Years of Intravenous Augmentation Therapy. (2019/09/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Beyond the lungs: Alpha-1 antitrypsin's potential role in human gestation. (2019/09/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Imaging Evaluation of Lung Transplantation Patients: A Time and Etiology-based Approach to High-resolution Computed Tomography Interpretation. (2019/09/01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Liver Fibrosis and Metabolic Alterations in Adults With alpha-1-antitrypsin Deficiency Caused by the Pi*ZZ Mutation. (2019/09/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Alpha-1 Antitrypsin Deficiency and Accelerated Aging: A New Model for an Old Disease? (2019/09/01) ♡
• SERPINA1 gene polymorphisms in a population-based ALSPAC cohort. (2019/09/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Imaging and the Lung Transplant Patient. (2019/09/01) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Looking into a Crystal Ball: An Interview with Ron Crystal. (2019/09/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Generalized emphysema and chronic obstructive pulmonary disease in a farmer, non-smoker - the more we seek, the more we find. (2019/08/30) ♡
• Plasma mitochondrial DNA is associated with extrapulmonary sarcoidosis. (2019/08/29) ♡
• Dataset of clinical, immunohistopathological and laboratory features of patients with MHC II deficiency suffering from enteropathy. (2019/08/28) ♡
• Adipose Mesenchymal Extracellular Vesicles as Alpha-1-Antitrypsin Physiological Delivery Systems for Lung Regeneration. (2019/08/23) ♡
• Bacterial load and inflammatory response in sputum of alpha-1 antitrypsin deficiency patients with COPD. (2019/08/21) ♡
• A specific proteinase 3 activity footprint in α(1)-antitrypsin deficiency. (2019/08/05) ♡
• The Impact of Delayed Diagnosis of Alpha-1 Antitrypsin Deficiency: The Association Between Diagnostic Delay and Worsened Clinical Status. (2019/08/01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. The Biological Effects of Double-Dose Alpha-1 Antitrypsin Augmentation Therapy. A Pilot Clinical Trial. (2019/08/01) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Is More Better? Promising Biological Effects of Double-Dose Alpha 1-Antitrypsin Therapy. (2019/08/01) ♡
• Diagnostic Yield of an Algorithm for Neonatal and Infantile Cholestasis Integrating Next-Generation Sequencing. (2019/08/01) ♡
• Functional characterization of a SNP (F51S) found in human alpha 1-antitrypsin. (2019/08/01) ♡
• Thiamin and protein folding. (2019/08/01) ♡
• Anxiety and depression in patients with alpha-1 antitrypsin deficiency: current insights and impact on quality of life. (2019/07/31) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Alpha-1 Antitrypsin Deficiency: A Predisposing Factor for the Development of Pulmonary Langerhans Cell Histiocytosis. (2019/07/24) ♡
• Protein modeling to assess the pathogenicity of rare variants of SERPINA1 in patients suspected of having Alpha 1 Antitrypsin Deficiency. (2019/07/15) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Severe bilateral descemetoceles in Alpha-1 antitrypsin deficiency. (2019/07/10) ♡
• Alpha-1 Antitrypsin Deficiency Liver Disease, Mutational Homogeneity Modulated by Epigenetic Heterogeneity With Links to Obesity. (2019/07/01) ♡
• Exome-based search for recurrent disease-causing alleles in Russian population. (2019/07/01) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Liver Disease Due to Alpha-1 Antitrypsin Deficiency: Are We Surprised That It Is More Complex Than We Thought? (2019/07/01) ♡
• Targeting the site encoded by SERPINA1*E342K for treating alpha-1 antitrypsin deficiency-associated liver diseases. (2019/07/01) ♡
• Alpha-1 Antitrypsin Replacement in Patients With COPD. (2019/07/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. [COPD - Smoking is not the only risk factor]. (2019/07/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Pneumothorax and lung cysts: a family affair. (2019/06/29) ♡
• Alpha-1-Antitrypsin Enhances Primary Human Macrophage Immunity Against Non-tuberculous Mycobacteria. (2019/06/26) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Heterozygous carriage of the alpha1-antitrypsin Pi*Z variant increases the risk to develop liver cirrhosis. (2019/06/01) ♡
• Changes in the Melting Point of Hybridization Probes Used for Genotyping in Alpha-1 Antitrypsin Deficiency Do Not Always Imply Errors. (2019/06/01) ♡
• Rapid single-breath hyperpolarized noble gas MRI-based biomarkers of airspace enlargement. (2019/06/01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Liver disease related to alpha1-antitrypsin deficiency in French children: The DEFI-ALPHA cohort. (2019/06/01) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Sex-specific differences in emphysema using a murine antisense oligonucleotide model of α-1 antitrypsin deficiency. (2019/06/01) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. DEFI-ALFA: The French key to the alpha1 mystery? (2019/06/01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Asthma as aetiology of bronchiectasis in Finland. (2019/06/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Multifocal pleomorphic dermal sarcoma and the role of inflammation and immunosuppression in a lung transplant patient: a case report. (2019/05/30) ♡
• Decline in FEV(1) and hospitalized exacerbations in individuals with severe alpha-1 antitrypsin deficiency. (2019/05/23) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. A combined in silico and in vitro study on mouse Serpina1a antitrypsin-deficiency mutants. (2019/05/16) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Limited GPA and Alpha-1 Antitrypsin Deficiency in a Pediatric Patient. (2019/05/01) ♡

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