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Alpha-1 antitrypsin deficiency

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Search Period All yearsLast 12 monthsLast 5 years Topic All topicsGeneralNutrition and dietAlternative treatment methods Type of research Any type of researchHighest Level of Evidence Only (35)Meta-analysis (8)Treatment guideline (5)Phase 3 study (8)Randomized trial (8)Systematic review (6)Clinical Trial (169)Review article (176)Early study (phase 1 or 2) (18)Case report (114)Laboratory or animal study (26)Commentary or editorial (90)Retracted publication (1) Only studies currently recruiting participants (28)

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Publications and studies (1172)

• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Protein Misfolding and Endoplasmic Reticulum Stress in Chronic Lung Disease: Will Cell-Specific Targeting Be the Key to the Cure? (2020/05/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Null(Canada): A novel α(1)-antitrypsin allele with in cis variants Glu366Lys and Ile100Asn. (2020/05/01) ♡
• Evaluation of a primary to secondary care referral pathway and novel nurse-led one-stop clinic for patients with suspected non-alcoholic fatty liver disease. (2020/04/07) ♡
• Adaptive NKG2C+ natural killer cells are related to exacerbations and nutritional abnormalities in COPD patients. (2020/03/04) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Combined Thoracic and Abdominal Organ Transplantation: Special Considerations. (2020/03/01) ♡
• Liver Involvement in Children with Alpha-1 Antitrypsin Deficiency: A Multicenter Study. (2020/03/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Genetics of COPD. (2020/02/10) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Serum Levels of Alpha1-antitrypsin and Their Relationship With COPD in the General Spanish Population. (2020/02/01) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. What Do Alpha-1 Antitrypsin Levels Tell Us About Chronic Inflammation in COPD? (2020/02/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Alpha-1 antitrypsin deficiency: a predisposing factor leading to invasive infections? (2020/02/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Diagnostic Performance of a Lateral Flow Assay for the Detection of Alpha-1-Antitrypsin Deficiency. (2020/02/01) ♡
• Production of α2,6-sialylated and non-fucosylated recombinant alpha-1-antitrypsin in CHO cells. (2020/01/10) ♡
• Increased Frequency of Heterozygous Alpha-1-Antitrypsin Deficiency in Liver Explants From Nonalcoholic Steatohepatitis Patients. (2020/01/01) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Food protein-induced enterocolitis and alpha-1-antitrypsin deficiency. (2020/01/01) ♡
• Liver organoids reproduce alpha-1 antitrypsin deficiency-related liver disease. (2020/01/01) ♡
• Assessment of coverage for endogenous metabolites and exogenous chemical compounds using an untargeted metabolomics platform. (2020/01/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Autophagy and Liver Diseases. (2020/01/01) ♡
• [Alpha-1 antitrypsin deficiency and spontaneous pneumothorax. Just a coincidence?]. (2020/01/01) ♡
• Macrophage Migration Inhibitory Factor is not Associated with Sarcoidosis Susceptibility or Severity in Whites or Blacks. (2020/01/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. A rare mutation on alpha-1 antitrypsin deficit and lung fibrosis: case report. (2020/01/01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Early Access Program Using Alpha 1 Antitrypsin Infusion for Patients With Steroid Refractory Acute GvHD After Hematopoietic Stem Cell Transplantation (HSCT) (2020-10-05) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. ARALAST NP Alpha-1 Lung Density Chronic Obstructive Pulmonary Disease-Emphysema (COPD-E) Study (2020-09-14) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Efficacy/Safety of HA Inhalation Solution for Hereditary Emphysema in Patients With Alpha-1 Antitrypsin Deficiency (2020-04-21) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Experimental Gene Transfer Procedure to Treat Alpha 1-Antitrypsin Deficiency (2020-04-10) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. EARCO REGISTRY. History Of Patients With Alpha-1 Antitrypsin (2020-02-07) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Phase II, Safety and Efficacy Study of Kamada-alpha-1-antitrypsin (AAT) for Inhalation" (2020-01-18) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Non-invasive assessment for alpha-1 antitrypsin deficiency-associated liver disease: new insights on steatosis and fibrosis in Pi*ZZ carriers. (2019/12/12) ♡
• Serum Alpha-1 Antitrypsin Levels and the Clinical Course of Chronic Obstructive Pulmonary Disease. (2019/12/10) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. A Novel Small Molecule Inhibits Intrahepatocellular Accumulation of Z-Variant Alpha 1-Antitrypsin In Vitro and In Vivo. (2019/12/06) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Pitfalls and caveats in α1-antitrypsin deficiency testing: a guide for clinicians. (2019/12/01) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Assessment of liver phenotype in adults with severe alpha-1 antitrypsin deficiency (Pi*ZZ genotype). (2019/12/01) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Reply to: "Assessment of liver phenotype in adults with severe alpha-1 antitrypsin deficiency (Pi*ZZ genotype)". (2019/12/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Managing the Alpha-1 patient in the ICU: Adapting broad critical care strategies in AATD. (2019/12/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Neonatal cholestasis, hyperferritinemia, hypoglycemia and deafness: a diagnostic challenge. (2019/12/01) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. A transgenic zebrafish model of hepatocyte function in human Z α1-antitrypsin deficiency. (2019/11/26) ♡
• Randomized researchiParticipants were divided into groups by lottery and compared with each other. This reduces the chance that a difference is due to something other than the treatment. Efficacy and safety of inhaled α1-antitrypsin in patients with severe α1-antitrypsin deficiency and frequent exacerbations of COPD. (2019/11/21) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Treatment with inhaled α1-antitrypsin: a square peg in a round hole? (2019/11/21) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Calcium signalling in mammalian cell lines expressing wild type and mutant human α1-Antitrypsin. (2019/11/21) ♡
• Diagnosing Alpha-1-Antitrypsin Deficiency Using A PCR/Luminescence-Based Technology. (2019/11/18) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. DGKα in Neutrophil Biology and Its Implications for Respiratory Diseases. (2019/11/13) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Oxidative Stress in COPD. (2019/11/13) ♡
• Mild Iron Overload as Seen in Individuals Homozygous for the Alpha-1 Antitrypsin Pi*Z Variant Does Not Promote Liver Fibrogenesis in HFE Knockout Mice. (2019/11/09) ♡
• Design and characterization of α1-antitrypsin variants for treatment of contact system-driven thromboinflammation. (2019/11/07) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Mevalonate kinase deficiency masked by cytomegalovirus infection and obscure liver disease. (2019/11/01) ♡
• Comparison of the liquid and lyophilized formulations of Prolastin®-C for Alpha(1)-Antitrypsin deficiency: Biochemical characteristics, pharmacokinetics, safety and neoantigenicity in rabbits. (2019/11/01) ♡
• Technique and outcome of domino liver transplantation from patients with maple syrup urine disease: Expanding the donor pool for live donor liver transplantation. (2019/11/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Genetic Causes of Liver Disease: When to Suspect a Genetic Etiology, Initial Lab Testing, and the Basics of Management. (2019/11/01) ♡
• Immunohistochemical and Ultrastructural Features of Hepatocellular Cytoplasmic Globules in Venous Outflow Impairment. (2019/10/07) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Don't Miss the BoAAT: Correctly Diagnosing Acute-on-Chronic Liver Disease. (2019/10/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Experimental and investigational drugs for the treatment of alpha-1 antitrypsin deficiency. (2019/10/01) ♡

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