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Alpha-1 antitrypsin deficiency

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Search Period All yearsLast 12 monthsLast 5 years Topic All topicsGeneralNutrition and dietAlternative treatment methods Type of research Any type of researchHighest Level of Evidence Only (35)Meta-analysis (8)Treatment guideline (5)Phase 3 study (8)Randomized trial (8)Systematic review (6)Clinical Trial (169)Review article (176)Early study (phase 1 or 2) (18)Case report (114)Laboratory or animal study (26)Commentary or editorial (90)Retracted publication (1) Only studies currently recruiting participants (28)

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Publications (1028)

• Increased expression or activation of TRPML1 reduces hepatic storage of toxic Z alpha-1 antitrypsin. (2023/09/06) ♡
• Genotypic Frequencies of Mutations Associated with Alpha-1 Antitrypsin Deficiency in Unrelated Bone Marrow Donors from the Murcia Region Donor Registry in the Southeast of Spain. (2023/09/02) ♡
• Modulation of the structural and functional properties of α1-antitrypsin by interaction with flavonoid luteolin. (2023/09/01) ♡
• A novel endoplasmic reticulum adaptation is critical for the long-lived Caenorhabditis elegans rpn-10 proteasomal mutant. (2023/09/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Alpha1-antitrypsin deficiency: An updated review. (2023/09/01) ♡
• Population genetic testing and SERPINA1 sequencing identifies unidentified alpha-1 antitrypsin deficiency alleles and gene-environment interaction with hepatitis C infection. (2023/08/31) ♡
• Utility of the Serum Protein Electrophoresis in the Opportunistic Screening for the Deficiency of Alpha-1 Antitrypsin. (2023/08/28) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Protein Phosphatase 2A as a Therapeutic Target in Pulmonary Diseases. (2023/08/26) ♡
• A Novel Provider Education Module to Enhance Detection of Alpha-1 Antitrypsin Deficiency. (2023/08/17) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Bilateral giant emphysematous bullae complicate severe bronchial asthma in a young patient: case report. (2023/08/14) ♡
• The prevalence of bronchiectasis in patients with alpha-1 antitrypsin deficiency: initial report of EARCO. (2023/08/12) ♡
• [Detection of cases of Alpha-1 Antitrypsin Deficiency, Should We Restrict or Expand?]. (2023/08/07) ♡
• Quantitative Lipid Profiling Reveals Major Differences between Liver Organoids with Normal Pi*M and Deficient Pi*Z Variants of Alpha-1-antitrypsin. (2023/08/05) ♡
• Recommendations for the Implementation of the Self-Administration of Alpha-1 Antitrypsin. (2023/08/04) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Beneficial effects of alpha-1 antitrypsin therapy in a mouse model of colitis-associated colon cancer. (2023/08/02) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Improving Detection of Alpha-1 Antitrypsin Deficiency: Role of the Allergist. (2023/08/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Mechanisms of organ fibrosis: Emerging concepts and implications for novel treatment strategies. (2023/08/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Pediatric and Adult Liver Disease in Alpha-1 Antitrypsin Deficiency. (2023/08/01) ♡
• Cryptogenic chronic hepatitis: looking for an ideal diagnostic algorithm. (2023/08/01) ♡
• Initial alpha-1 antitrypsin screening in Turkish patients with chronic obstructive pulmonary disease. (2023/08/01) ♡
• Impact of Bronchiectasis on COPD Severity and Alpha-1 Antitrypsin Deficiency as a Risk Factor in Individuals with a Heavy Smoking History. (2023/07/26) ♡
• Augmentation Therapy Modulates Systemic Inflammation in Individuals with Alpha-1 Antitrypsin Deficiency and Chronic Obstructive Pulmonary Disease. (2023/07/26) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Diagnosis and augmentation therapy for alpha-1 antitrypsin deficiency: current knowledge and future potential. (2023/07/20) ♡
• Predicting Lung Function Using Biomarkers in Alpha-1 Antitrypsin Deficiency. (2023/07/15) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. NAFLD and AATD Are Two Diseases with Unbalanced Lipid Metabolism: Similarities and Differences. (2023/07/12) ♡
• Meta-analysisiAll studies on one question combined and calculated together. This is the strongest form of research that exists: a single loose study can be coincidence, dozens together much less so. The label says something about the design, not about the outcome — which can also be that something does NOT work. Meta-analysis: Prevalence of significant or advanced fibrosis in adults with alpha-1-antitrypsin deficiency. (2023/07/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Practical dietary advices for subjects with alpha-1 antitrypsin deficiency. (2023/07/01) ♡
• Current Perspectives of Pharmacotherapies for COPD. (2023/07/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. RNAi therapeutics for diseases involving protein aggregation: fazirsiran for alpha-1 antitrypsin deficiency-associated liver disease. (2023/07/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Alpha-1-antitrypsin antagonizes COVID-19: a review of the epidemiology, molecular mechanisms, and clinical evidence. (2023/06/28) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Preservation solution Custodiol containing human alpha-1-antitrypsin improves graft recovery after prolonged cold ischemic storage in a rat model of heart transplantation. (2023/06/22) ♡
• Increased Prevalence of Alpha-1-Antitrypsin Deficiency in Patients with Biliary Tract Cancer and Its Associated Clinicopathological Features. (2023/06/19) ♡
• Physical Activity, Exercise Capacity and Sedentary Behavior in People with Alpha-1 Antitrypsin Deficiency: A Scoping Review. (2023/06/16) ♡
• Estimating the Prevalence of AATD Patients in the UK to Identify Underdiagnosis and Determine the Eligibility for Potential Augmentation Therapy. (2023/06/13) ♡
• Lung microhaemorrhage drives oxidative/inflammatory damage in α(1)-antitrypsin deficiency. (2023/06/12) ♡
• [Results of the Implementation of a Case-Finding Program for Alpha-1 Antitrypsin Deficiency in COPD Patients]. (2023/06/09) ♡
• Distribution of alpha1 antitrypsin rare alleles in six countries: Results from the Progenika diagnostic network. (2023/06/05) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Alpha-1 Antitrypsin Deficiency. (2023/06/01) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Important steps towards a big change for lung health: a joint approach by the European Respiratory Society, the European Society of Radiology and their partners to facilitate implementation of the European Union's new recommendations on lung cancer screening. (2023/05/09) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Prevalence of genetic mutations in alpha-1 antitrypsin deficiency (aatd) in patients with chronic obstructive pulmonary disease in Colombia. (2023/05/04) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Cleaning up alpha-1 antitrypsin deficiency related liver disease. (2023/05/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. [Not a pneumothorax again! Birt-Hogg-Dubé syndrome: a case report]. (2023/05/01) ♡
• Undersampled Diffusion-Weighted (129)Xe MRI Morphometry of Airspace Enlargement: Feasibility in Chronic Obstructive Pulmonary Disease. (2023/04/19) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. SARS-CoV-2 Infection Precipitates the Discovery of Underlying Liver Disease: A Case Report. (2023/04/19) ♡
• Hypoxia Enhances Oxidative Stress in Neutrophils from ZZ Alpha-1 Antitrypsin Deficiency Patients. (2023/04/03) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Alpha-1 antitrypsin deficiency. (2023/03/10) ♡
• Serum Protein Electrophoretic in Children. (2023/03/02) ♡
• Adequacy of Iodine Status and Associations with Gut Health: A Prospective Cohort Study among Infants in 8 Low- and Middle-Income Countries. (2023/03/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Epidemiology and prevalence of lean nonalcoholic fatty liver disease and associated cirrhosis, hepatocellular carcinoma, and cardiovascular outcomes in the United States: a population-based study and review of literature. (2023/02/01) ♡
• Alpha-1-Antitrypsin Pi*MZ variant increases risk of developing hepatic events in nonalcoholic fatty liver disease patients(). (2023/02/01) ♡

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