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Alpha-1 antitrypsin deficiency

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Search Period All yearsLast 12 monthsLast 5 years Topic All topicsGeneralNutrition and dietAlternative treatment methods Type of research Any type of researchHighest Level of Evidence Only (35)Meta-analysis (8)Treatment guideline (5)Phase 3 study (8)Randomized trial (8)Systematic review (6)Clinical Trial (169)Review article (176)Early study (phase 1 or 2) (18)Case report (114)Laboratory or animal study (26)Commentary or editorial (90)Retracted publication (1) Only studies currently recruiting participants (28)

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Publications (1028)

• Long-term effect of α(1)-antitrypsin augmentation therapy on the decline of FEV(1) in deficient patients: an analysis of the AIR database. (2021/08/23) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. In Vitro Investigations on Optimizing and Nebulization of IVT-mRNA Formulations for Potential Pulmonary-Based Alpha-1-Antitrypsin Deficiency Treatment. (2021/08/17) ♡
• Quantitative measurement of the histological features of alpha-1 antitrypsin deficiency-associated liver disease in biopsy specimens. (2021/08/16) ♡
• The Induction of Alpha-1 Antitrypsin by Vitamin D in Human T Cells Is TGF-β Dependent: A Proposed Anti-inflammatory Role in Airway Disease. (2021/08/12) ♡
• Alpha-1 Antitrypsin Augmentation Inhibits Proteolysis of Neutrophil Membrane Voltage-Gated Proton Channel-1 in Alpha-1 Deficient Individuals. (2021/08/10) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. The spectrum of Epstein-Barr virus infections of the central nervous system after organ transplantation. (2021/08/06) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. How Do Mechanics Guide Fibroblast Activity? Complex Disruptions during Emphysema Shape Cellular Responses and Limit Research. (2021/08/05) ♡
• SARS-CoV-2 infection in alpha1-antitrypsin deficiency. (2021/08/01) ♡
• Transient Elastography in Pediatric Liver Disease. (2021/08/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Concomitant congenital CMV infection and inherited liver diseases. (2021/08/01) ♡
• COVID-19 vaccination in patients with α1-antitrypsin deficiency. (2021/08/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Alpha1-antitrypsin deficiency: New therapies on the horizon. (2021/08/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Liver disease with unknown etiology - have you ruled out alpha-1 antitrypsin deficiency? (2021/07/29) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. The spectrum of clinical sequelae associated with alpha-1 antitrypsin deficiency. (2021/07/29) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Lung and liver transplantation in patients with alpha-1 antitrypsin deficiency. (2021/07/29) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Management of lung disease in alpha-1 antitrypsin deficiency: what we do and what we do not know. (2021/07/29) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Alpha-1 antitrypsin deficiency research and emerging treatment strategies: what's down the road? (2021/07/29) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Variants of SERPINA1 and the increasing complexity of testing for alpha-1 antitrypsin deficiency. (2021/07/29) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Imaging in alpha-1 antitrypsin deficiency: a window into the disease. (2021/07/29) ♡
• Challenges Faced by Rural Primary Care Providers When Caring for COPD Patients in the Western United States. (2021/07/28) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Understanding the genetics of chronic obstructive pulmonary disease, α1-antitrypsin deficiency, and implications for clinical practice. (2021/07/28) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. The Course of AαVal541 as a Proteinase 3 Specific Neo-Epitope after Alpha-1-Antitrypsin Augmentation in Severe Deficient Patients. (2021/07/27) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. [Alpha-1-antitrypsin deficiency]. (2021/07/26) ♡
• Therapeutic benefits of recombinant alpha1-antitrypsin IgG1 Fc-fusion protein in experimental emphysema. (2021/07/16) ♡
• Hypoimmune induced pluripotent stem cell-derived cell therapeutics treat cardiovascular and pulmonary diseases in immunocompetent allogeneic mice. (2021/07/13) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. COVID-19 infection in severe Alpha 1-antitrypsin deficiency: Looking for a rationale. (2021/07/01) ♡
• Association of Alpha 1-antitrypsin Deficiency and Genetic Predisposition in Primary Spontaneous Pneumothorax. (2021/07/01) ♡
• miR-320c Regulates SERPINA1 Expression and Is Induced in Patients With Pulmonary Disease. (2021/07/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. The Recruitment-Secretory Block ("R-SB") Phenomenon and Endoplasmic Reticulum Storage Diseases. (2021/06/24) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Unusual presentation of Crohn's disease. (2021/06/09) ♡
• Z-alpha1-antitrypsin polymers and small airways disease: a new paradigm in alfa-1 anti-trypsin deficiency-related COPD development? (2021/06/08) ♡
• Alpha-1 Antitrypsin Deficiency-Associated Clinical Manifestations and Healthcare Resource Use in the United States. (2021/06/01) ♡
• [Alpha-1 antitrypsin deficiency: cause and cofactor for liver disease]. (2021/06/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Protease-Antiprotease Imbalance in Bronchiectasis. (2021/06/01) ♡
• Update on and future perspectives for the diagnosis of alpha-1 antitrypsin deficiency in Brazil. (2021/05/31) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Hepatic and Extrahepatic Sources and Manifestations in Endoplasmic Reticulum Storage Diseases. (2021/05/28) ♡
• The Importance of N186 in the Alpha-1-Antitrypsin Shutter Region Is Revealed by the Novel Bologna Deficiency Variant. (2021/05/26) ♡
• Polymerization of misfolded Z alpha-1 antitrypsin protein lowers CX3CR1 expression in human PBMCs. (2021/05/18) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Alpha-1 antitrypsin deficiency in the elderly: a case report. (2021/05/10) ♡
• Pleiotropic associations of heterozygosity for the SERPINA1 Z allele in the UK Biobank. (2021/05/10) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. A PI*MS is not always a PI*MS. An example of when genotyping for alpha-1 antitrypsin deficiency is necessary. (2021/05/01) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Alpha 1-Antitrypsin deficiency in liver explants in a Mexican cohort: A unique cohort to assess the role of heterozygous genotypes in liver disease. (2021/05/01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Long term results of liver transplantation for alpha-1 antitrypsin deficiency. (2021/05/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Alpha(1)-antitrypsin Disease, Treatment and Role for Lung Volume Reduction Surgery. (2021/05/01) ♡
• Epidemiological correlation between COVID-19 epidemic and prevalence of α-1 antitrypsin deficiency in the world. (2021/04/30) ♡
• Relationship Between α(1)-Antitrypsin Deficiency and Ascending Aortic Distention. (2021/04/30) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Heterozygous Alpha-1 Antitrypsin Deficiency Causing Pulmonary Emboli and Pulmonary Bullae. (2021/04/29) ♡
• Hepatocyte proteomes reveal the role of protein disulfide isomerase 4 in alpha 1-antitrypsin deficiency. (2021/04/24) ♡
• Do gene-environment interactions play a role in COVID-19 distribution? The case of Alpha-1 Antitrypsin, air pollution and COVID-19. (2021/04/22) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Therapeutic Potential of Alpha-1 Antitrypsin in Type 1 and Type 2 Diabetes Mellitus. (2021/04/20) ♡

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