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Thalassemia (severe form)

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Search Period All yearsLast 12 monthsLast 5 years Topic All topicsGeneralNutrition and dietAlternative treatment methods Type of research Any type of researchOnly the strongest evidence (53)Meta-analysis (12)Treatment guideline (1)Randomized trial (20)Systematic review (12)Phase 3 study (8)Clinical trial (379)Review article (138)Early study (phase 1 or 2) (18)Case report (134)Laboratory or animal research (17)Commentary or editorial (44)Retracted publication (2) Studies currently recruiting participants only (31)

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Publications and studies (1521)

• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Headache in beta-thalassemia: An Italian multicenter clinical, conventional MRI and MR-angiography case-control study. (2020/03/01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Safety and effectiveness of thalidomide and hydroxyurea combination in β-thalassaemia intermedia and major: a retrospective pilot study. (2020/02/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. The transactional model of stress and coping as guidance for understanding adolescent patients' experience with thalassemia: Case report. (2020/02/01) ♡
• Oridonin enhances γ‑globin expression in erythroid precursors from patients with β‑thalassemia via activation of p38 MAPK signaling. (2020/02/01) ♡
• Evaluating viscoelastic properties and membrane electrical charges of red blood cells with optical tweezers and cationic quantum dots - applications to β-thalassemia intermedia hemoglobinopathy. (2020/02/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Haploidentical bone marrow transplantation in a patient with sickle cell disease and acute myeloid leukemia. (2020/02/01) ♡
• New activators of eIF2α Kinase Heme-Regulated Inhibitor (HRI) with improved biophysical properties. (2020/02/01) ♡
• Systematic reviewiAll research on one question is searched according to fixed rules and compared side by side, so that no studies with poor outcomes are missed. Systematic Literature Review of the Burden of Disease and Treatment for Transfusion-dependent β-Thalassemia. (2020/02/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Ocular abnormalities in beta thalassemia patients: prevalence, impact, and management strategies. (2020/02/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Sharpening the Molecular Scissors: Advances in Gene-Editing Technology. (2020/01/24) ♡
• Rare Co-occurrence of Beta-Thalassemia and Pseudoxanthoma elasticum: Novel Biomolecular Findings. (2020/01/23) ♡
• Co-inheritance of alpha globin gene deletion lowering serum iron level in female beta thalassemia patients. (2020/01/01) ♡
• Phenotypic-screening generates active novel fetal globin-inducers that downregulate Bcl11a in a monkey model. (2020/01/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Regulation of GATA1 levels in erythropoiesis. (2020/01/01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. A novel SNP rs11759328 on Rho GTPase-activating protein 18 gene is associated with the expression of Hb F in hemoglobin E-related disorders. (2020/01/01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Erythroferrone, the new iron regulator: evaluation of its levels in Egyptian patients with beta thalassemia. (2020/01/01) ♡
• Phenotypic Diversity and Clinico-Hematological Profile of Hb E-Beta Thalassemic Children. (2020/01/01) ♡
• Key Determinants of Phenotypic Heterogeneity of Hb E/β Thalassemia: A Comparative Study from Eastern India. (2020/01/01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Reproductive Capacity and Iron Burden in Thalassemia (2020-12-23) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Home-based Assessment of PRO Measures in SCD Using A Smartphone App Platform: A Feasibility Study (2020-12-21) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Frequency of COVID-19 Antibodies in Patients With Hereditary Hematological Diseases (2020-11-09) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. SP-420 in Subjects With Transfusion-dependent Beta-Thalassemia or Other Rare Anemias (2020-10-05) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Evaluation of Nutritional Status in Thalassemia Major Patients in Assiut Children Hospital (2020-07-30) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Choroidal Thickness in Beta-thalassemia Patients (2020-06-26) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Allogeneic Stem Cell Transplantation, Severe Homzygous 0/+Thalassemia or Sever Variants of Beta 0/+ Thalassemia, THALLO (2020-05-01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Congenital Heart Surgery in Pediatric Patients With Beta-Thalassemia Major (2020-04-29) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Study in Beta-thalassaemia or Myelodysplastic Syndrome Patients to Investigate the Safety and Tolerability of SLN124 (2020-04-27) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. The Role of Endothelin-1 in Sickle Cell Disease (2020-04-02) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. The Effect of N-acetylcysteine on Oxidative Stress Status and Iron Overload in Thalassemia Major (2020-02-07) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Efficacy and Safety of Neridronate (Nerixia®)to Treat Osteoporosis in Patients With TM and TI (2020-02-05) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Gum Arabic as Anti-oxidant, Anti-inflammatory and Fetal Hemoglobin Inducing Agent in Sickle Cell Anemia Patients (2020-01-28) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Resistance Exercise on Postprandial Hyperglycemia in Patients With B-thalassemia Exhibiting Resistance to Insulin (2020-01-18) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Complications in Children With B- Thalassemia Major (2020-01-18) ♡
• Quality of life outcomes in thalassaemia patients in Saudi Arabia: a cross-sectional study. (2019/12/29) ♡
• Cd60 (GTG > GAG)/Hb Cagliari mutation was found in scanning of β-thalassemia alleles from patients of East Kalimantan, Indonesia. (2019/12/20) ♡
• Short Tandem Repeats Used in Preimplantation Genetic Testing of Β-Thalassemia: Genetic Polymorphisms For 15 Linked Loci in the Vietnamese Population. (2019/12/20) ♡
• Deferiprone and efonidipine mitigated iron-overload induced neurotoxicity in wild-type and thalassemic mice. (2019/12/15) ♡
• Use of an automated pyrosequencing technique for confirmation of sickle cell disease. (2019/12/12) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Expression analysis data of BCL11A and γ-globin genes in KU812 and KG-1 cell lines after CRISPR/Cas9-mediated BCL11A enhancer deletion. (2019/12/11) ♡
• [Study on the characteristics of major birth defects in 1.69 million cases of fetus in Guangxi Zhuang Autonomous Region]. (2019/12/10) ♡
• Diagnostic performance of hematological discrimination indices to discriminate between beta thalassemia trait and iron deficiency anemia and using cluster analysis: Introducing two new indices tested in Iranian population. (2019/12/09) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. An Unusual Presentation of a Patient with Leg Ulcers: A Case Report. (2019/12/05) ♡
• Hemorheological Alterations and Oxidative Damage in Sickle Cell Anemia. (2019/12/04) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Erythropoiesis In Vitro—A Research and Therapeutic Tool in Thalassemia. (2019/12/02) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Noninvasive assessment and risk factors of liver fibrosis in patients with thalassemia major using shear wave elastography. (2019/12/01) ♡
• Differential role of Kruppel like factor 1 (KLF1) gene in red blood cell disorders. (2019/12/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Animal Models of Normal and Disturbed Iron and Copper Metabolism. (2019/12/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Red cell alloimmunization in transfusion-dependent and transfusion-independent beta thalassemia: A review from the Eastern Mediterranean Region (EMRO). (2019/12/01) ♡
• Karyomapping in preimplantation genetic testing for β-thalassemia combined with HLA matching: a systematic summary. (2019/12/01) ♡
• Consanguineous unions and endogamy in families of beta-thalassaemia patients from two Mediterranean populations: Tunisia and Italy. (2019/12/01) ♡

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