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Primary lateral sclerosis

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Search Period All yearsLast 12 monthsLast 5 years Topic All topicsGeneralNutrition and dietAlternative treatment methods Type of research Any type of researchHighest evidence only (123)Meta-analysis (29)Treatment guideline (6)Systematic review (51)Randomized controlled trial (19)Phase 3 study (18)Clinical trial (658)Review article (337)Early-stage study (phase 1 or 2) (13)Laboratory or animal research (123)Case description (120)Commentary or editorial (46)Retracted publication (1) Studies currently recruiting participants only (31)

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Publications and studies (2510)

• Prognostic significance of body weight variation after diagnosis in ALS: a single-centre prospective cohort study. (2019/06/01) ♡
• Investigating the Risk of Equine Motor Neuron Disease in a Brazilian Stable and Successful Intervention. (2019/06/01) ♡
• Zein-CMC-PEG Multiple Nanocolloidal Systems as a Novel Approach for Nutra-Pharmaceutical Applications. (2019/06/01) ♡
• Randomized researchiParticipants were divided into groups by lottery and compared with each other. This reduces the chance that a difference is due to something other than the treatment. Nutritional counseling with or without mobile health technology: a randomized open-label standard-of-care-controlled trial in ALS. (2019/05/29) ♡
• Systematic reviewiAll research on one question is searched according to fixed rules and compared side by side, so that no studies with poor outcomes are missed. Does Acupuncture Protect Dopamine Neurons in Parkinson's Disease Rodent Model?: A Systematic Review and Meta-Analysis. (2019/05/08) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Enhanced oxidative stress and the treatment by edaravone in mice model of amyotrophic lateral sclerosis. (2019/05/01) ♡
• SYNE1-ataxia: Novel genotypic and phenotypic findings. (2019/05/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Variant ataxia-telangiectasia with prominent camptocormia. (2019/05/01) ♡
• Randomized researchiParticipants were divided into groups by lottery and compared with each other. This reduces the chance that a difference is due to something other than the treatment. Longitudinal evaluation of SMN levels as biomarker for spinal muscular atrophy: results of a phase IIb double-blind study of salbutamol. (2019/05/01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Titration of Mechanical Insufflation-Exsufflation Optimal Pressure Combinations in Neuromuscular Diseases by Flow/Pressure Waveform Analysis. (2019/05/01) ♡
• Neuroimaging and clinical trials with stem cells in amyotrophic lateral sclerosis: present and future perspectives. (2019/05/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Staging amyotrophic lateral sclerosis: A new focus on progression. (2019/05/01) ♡
• MicroRNA-26a/Death-Associated Protein Kinase 1 Signaling Induces Synucleinopathy and Dopaminergic Neuron Degeneration in Parkinson's Disease. (2019/05/01) ♡
• Is the evidence strong enough for acupuncture ameliorates clinical symptoms in patients with amyotrophic lateral sclerosis: A protocol for a systematic review and meta-analysis. (2019/05/01) ♡
• Improved survival and 30-day mortality after gastrostomy in Scottish motor neurone disease patients: evidence from a national retrospective cohort study using STROBE criteria. (2019/05/01) ♡
• Prediagnostic plasma branched-chain amino acids and the risk of amyotrophic lateral sclerosis. (2019/04/30) ♡
• Prediagnostic plasma metabolomics and the risk of amyotrophic lateral sclerosis. (2019/04/30) ♡
• Scurfy Mice Develop Features of Connective Tissue Disease Overlap Syndrome and Mixed Connective Tissue Disease in the Absence of Regulatory T Cells. (2019/04/24) ♡
• Decreased circulating ErbB4 ectodomain fragments as a read-out of impaired signaling function in amyotrophic lateral sclerosis. (2019/04/01) ♡
• Mutant SOD1 prevents normal functional recovery through enhanced glial activation and loss of motor neuron innervation after peripheral nerve injury. (2019/04/01) ♡
• Bojungikgi-tang Improves Muscle and Spinal Cord Function in an Amyotrophic Lateral Sclerosis Model. (2019/04/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. 2,4 Dinitrophenol as Medicine. (2019/03/23) ♡
• Starting and stopping movement by the primate brain. (2019/03/15) ♡
• TDP-43 levels are higher in platelets from patients with sporadic amyotrophic lateral sclerosis than in healthy controls. (2019/03/01) ♡
• Pre-Nusinersen Hospitalization Costs of Children With Spinal Muscular Atrophy. (2019/03/01) ♡
• Investigation of mitochondrial calcium uniporter role in embryonic and adult motor neurons from G93A(hSOD1) mice. (2019/03/01) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. HIV related motor neuron disease/syndrome: The - potentially treatable - retroviral link in ALS? (2019/02/15) ♡
• Disease progression impacts health-related quality of life in amyotrophic lateral sclerosis. (2019/02/15) ♡
• A comparative study of motor neuron disease in HIV-infected and HIV-uninfected patients. (2019/02/15) ♡
• Intravenous immunoglobulins in patients with clinically suspected chronic immune-mediated neuropathy. (2019/02/15) ♡
• Electrodiagnostic consultations in Zambia: Referral characteristics and neuromuscular disorders. (2019/02/15) ♡
• A homozygous canonical splice acceptor site mutation in PRUNE1 is responsible for a rare childhood neurodegenerative disease in Manitoba Cree families. (2019/02/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Harnessing cellular aging in human stem cell models of amyotrophic lateral sclerosis. (2019/02/01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Diagnostic criteria for amyotrophic lateral sclerosis: A multicentre study of inter-rater variation and sensitivity. (2019/02/01) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Is it time to depart from dichotomization in ALS diagnosis? (2019/02/01) ♡
• Systematic reviewiAll research on one question is searched according to fixed rules and compared side by side, so that no studies with poor outcomes are missed. Screening for cognitive and behavioral change in amyotrophic lateral sclerosis/motor neuron disease: a systematic review of validated screening methods. (2019/02/01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Spinal muscular atrophy with respiratory distress type 1: A multicenter retrospective study. (2019/02/01) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Spy1, a unique cell cycle regulator, alters viability in ALS motor neurons and cell lines in response to mutant SOD1-induced DNA damage. (2019/02/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Konzo: a distinct neurological disease associated with food (cassava) cyanogenic poisoning. (2019/02/01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Taste changes in amyotrophic lateral sclerosis and effects on quality of life. (2019/02/01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Health outcomes in spinal muscular atrophy type 1 following AVXS-101 gene replacement therapy. (2019/02/01) ♡
• Physicians' attitudes toward end-of-life decisions in amyotrophic lateral sclerosis. (2019/02/01) ♡
• Eating peptides: biomarkers of neurodegeneration in amyotrophic lateral sclerosis and frontotemporal dementia. (2019/01/31) ♡
• ALS-Linked SOD1 Mutants Enhance Neurite Outgrowth and Branching in Adult Motor Neurons. (2019/01/25) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. RNA Dysregulation in Amyotrophic Lateral Sclerosis. (2019/01/22) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Brain Derived Neurotrophic Factor (BDNF) Delays Onset of Pathogenesis in Transgenic Mouse Model of Spinocerebellar Ataxia Type 1 (SCA1). (2019/01/21) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Swim Training Modulates Mouse Skeletal Muscle Energy Metabolism and Ameliorates Reduction in Grip Strength in a Mouse Model of Amyotrophic Lateral Sclerosis. (2019/01/09) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Functional Biomarkers for Amyotrophic Lateral Sclerosis. (2019/01/04) ♡
• Enhancing GABAergic Transmission Improves Locomotion in a Caenorhabditis elegans Model of Spinal Muscular Atrophy. (2019/01/02) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. LncRNA MIAT overexpression reduced neuron apoptosis in a neonatal rat model of hypoxic-ischemic injury through miR-211/GDNF. (2019/01/01) ♡

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