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Primary lateral sclerosis

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Search Period All yearsLast 12 monthsLast 5 years Topic All topicsGeneralNutrition and dietAlternative treatment methods Type of research Any type of researchHighest evidence only (123)Meta-analysis (29)Treatment guideline (6)Systematic review (51)Randomized controlled trial (19)Phase 3 study (18)Clinical trial (658)Review article (336)Early-stage study (phase 1 or 2) (13)Laboratory or animal research (123)Case description (120)Commentary or editorial (46)Retracted publication (1) Studies currently recruiting participants only (31)

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Publications and studies (2508)

• Spinal subpial delivery of AAV9 enables widespread gene silencing and blocks motoneuron degeneration in ALS. (2020/01/01) ♡
• 244th ENMC international workshop: Newborn screening in spinal muscular atrophy May 10-12, 2019, Hoofdorp, The Netherlands. (2020/01/01) ♡
• Applying the D50 disease progression model to gray and white matter pathology in amyotrophic lateral sclerosis. (2020/01/01) ♡
• Species-specific consequences of an E40K missense mutation in superoxide dismutase 1 (SOD1). (2020/01/01) ♡
• Optimized artificial neural network based performance analysis of wheelchair movement for ALS patients. (2020/01/01) ♡
• Verbal Semantics and the Left Dorsolateral Anterior Temporal Lobe: A Longitudinal Case of Bilateral Temporal Degeneration. (2020/01/01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Effects of electroacupuncture on patients with chronic urinary retention caused by a lower motor neuron lesion: An exploratory pilot study. (2020/01/01) ♡
• Gender-Specific Beneficial Effects of Docosahexaenoic Acid Dietary Supplementation in G93A-SOD1 Amyotrophic Lateral Sclerosis Mice. (2020/01/01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. RESTORE: A Prospective Multinational Registry of Patients with Genetically Confirmed Spinal Muscular Atrophy - Rationale and Study Design. (2020/01/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. [Consideration of Advanced Pharmaceutical Control Functions through Pharmacy-provided Home Pharmaceutical Care]. (2020/01/01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Progression of brain functional connectivity and frontal cognitive dysfunction in ALS. (2020/01/01) ♡
• Fiber-specific white matter reductions in amyotrophic lateral sclerosis. (2020/01/01) ♡
• The Prevalence and Management of Saliva Problems in Motor Neuron Disease: A 4-Year Analysis of the Scottish Motor Neuron Disease Register. (2020/01/01) ♡
• The prevalence of muscular dystrophy and spinal muscular atrophy in Croatia: data from national and non-governmental organization registries. (2019/12/31) ♡
• Exposure of a cryptic Hsp70 binding site determines the cytotoxicity of the ALS-associated SOD1-mutant A4V. (2019/12/31) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Genomic analysis of a spinal muscular atrophy (SMA) discordant family identifies a novel mutation in TLL2, an activator of growth differentiation factor 8 (myostatin): a case report. (2019/12/30) ♡
• First validation of a novel assessgame quantifying selective voluntary motor control in children with upper motor neuron lesions. (2019/12/30) ♡
• Unique molecular signature in mucolipidosis type IV microglia. (2019/12/28) ♡
• The loss of dopaminergic neurons in DEC1 deficient mice potentially involves the decrease of PI3K/Akt/GSK3β signaling. (2019/12/28) ♡
• TDP-43 aggregation inside micronuclei reveals a potential mechanism for protein inclusion formation in ALS. (2019/12/27) ♡
• Dominant Heterogeneity of Upper and Lower Motor Neuron Degeneration to Motor Manifestation of Involved Region in Amyotrophic Lateral Sclerosis. (2019/12/27) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. The potassium channel KCa3.1 represents a valid pharmacological target for microgliosis-induced neuronal impairment in a mouse model of Parkinson's disease. (2019/12/26) ♡
• TDP-43-Mediated Toxicity in HEK293T Cells: A Fast and Reproducible Protocol To Be Employed in the Search of New Therapeutic Options against Amyotrophic Lateral Sclerosis. (2019/12/26) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Sleep in the completely locked-in state (CLIS) in amyotrophic lateral sclerosis. (2019/12/24) ♡
• Roles of Collagen XXV and Its Putative Receptors PTPσ/δ in Intramuscular Motor Innervation and Congenital Cranial Dysinnervation Disorder. (2019/12/24) ♡
• Antiviral Immune Response as a Trigger of FUS Proteinopathy in Amyotrophic Lateral Sclerosis. (2019/12/24) ♡
• Relaxation of synaptic inhibitory events as a compensatory mechanism in fetal SOD spinal motor networks. (2019/12/23) ♡
• DRG2 Deficient Mice Exhibit Impaired Motor Behaviors with Reduced Striatal Dopamine Release. (2019/12/20) ♡
• Association between ALS and retroviruses: evidence from bioinformatics analysis. (2019/12/20) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Developing a web-based patient decision aid for gastrostomy in motor neuron disease: a study protocol. (2019/12/18) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. The Challenge and Opportunity to Diagnose Parkinson's Disease in Midlife. (2019/12/17) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Therapeutic alternative of the ketogenic Mediterranean diet to improve mitochondrial activity in Amyotrophic Lateral Sclerosis (ALS): A Comprehensive Review. (2019/12/16) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Editorial: Biomarkers and Clinical Indicators in Motor Neuron Disease. (2019/12/12) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. ALS or ALS mimic by neuroborreliosis-A case report. (2019/12/11) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Mechanisms of Immune Activation by c9orf72-Expansions in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. (2019/12/10) ♡
• Systematic reviewiAll research on one question is searched according to fixed rules and compared side by side, so that no studies with poor outcomes are missed. Swimming in Deep Water: Zebrafish Modeling of Complicated Forms of Hereditary Spastic Paraplegia and Spastic Ataxia. (2019/12/10) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Long-Term Voluntary Physical Exercise Exerts Neuroprotective Effects and Motor Disturbance Alleviation in a Rat Model of Parkinson's Disease. (2019/12/05) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Complementary and alternative medicine for treating amyotrophic lateral sclerosis: A narrative review. (2019/12/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. TDRKH is a candidate gene for an autosomal dominant distal hereditary motor neuropathy. (2019/12/01) ♡
• Anthropometric measurement standardization for a multicenter nutrition survey in children with spinal muscular atrophy. (2019/12/01) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. The role of skeletal muscle in amyotrophic lateral sclerosis: a 'dying-back' or 'dying-forward' phenomenon? (2019/12/01) ♡
• Development and Validation of the Self-care in Motor Neuron Disease Index. (2019/12/01) ♡
• Amyotrophic lateral sclerosis incidence following exposure to inorganic selenium in drinking water: A long-term follow-up. (2019/12/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Spinal Muscular Atrophy Modeling and Treatment Advances by Induced Pluripotent Stem Cells Studies. (2019/12/01) ♡
• Physiological aspects of muscular adaptations to training translated to neuromuscular diseases. (2019/12/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Exercise therapy for muscle and lower motor neuron diseases. (2019/12/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. COMPLEX TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS PATIENT. (2019/12/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Subacute combined degeneration of the spinal cord masking motor neuron disease: a case report. (2019/11/18) ♡
• Newborn Screening for Spinal Muscular Atrophy: DNA Preparation from Dried Blood Spot and DNA Polymerase Selection in PCR. (2019/11/14) ♡
• Spastic paraplegia due to recessive or dominant mutations in ERLIN2 can convert to ALS. (2019/11/13) ♡

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