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Primary lateral sclerosis
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Publications and studies (2507)
- Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. A prospective, multi-center, observational study of the safety, tolerability and effectiveness of Nusinersen in adult patients with spinal muscular atrophy. (2026/05/01) ♡
- Spike RBD drives sustained Parkinson's disease progression via microglia-neuron crosstalk-mediated RTP801 upregulation. (2026/05/01) ♡
- The Impact of Cognitive Impairment on Advance Care Planning and Healthcare Utilization in People With ALS. (2026/05/01) ♡
- Incidence of MND in Canterbury, New Zealand and impact of a key worker role on hospital admissions. (2026/05/01) ♡
- Prevalence and Risk Factors of Dysphagia in Amyotrophic Lateral Sclerosis: A Retrospective Study Using the Nationwide Inpatient Sample Database. (2026/05/01) ♡
- Maximal motor unit firing rates decline with amyotrophic lateral sclerosis progression. (2026/05/01) ♡
- Pediatric Spinal Muscular Atrophy Patients Treated With Nusinersen: Experience From a Tertiary Referral Center in Turkey. (2026/05/01) ♡
- Nusinersen for type-III spinal muscular atrophy: a 12-month retrospective study in a Brazilian cohort. (2026/05/01) ♡
- Systematic reviewiAll research on one question is searched according to fixed rules and compared side by side, so that no studies with poor outcomes are missed. Efficacy and safety of pharmacological and biological therapies for amyotrophic lateral sclerosis: a network meta-analysis. (2026/04/24) ♡
- Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Dietary monounsaturated fatty acids reduce nerve inflammation and improve nerve function in murine models of obesity. (2026/04/15) ♡
- Weight maintenance following enteral nutrition is associated with prolonged survival in amyotrophic lateral sclerosis. (2026/04/11) ♡
- Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Dietary Yam (Dioscorea opposita Thunb.) Ameliorates Parkinson's Disease in Mice via Gut Microbiota-Driven Mitochondrial Improvement and Neuroinflammation Inhibition. (2026/04/11) ♡
- Synergistic Neuroprotection of MFSD2A Overexpression and DHA Supplementation in Amyotrophic Lateral Sclerosis. (2026/04/09) ♡
- TMBIM6 enhances dopaminergic neuron survival by modulating the IRE1a pathway in Parkinson's disease. (2026/04/03) ♡
- Phase 3 studyiResearch in a large group of patients, the final step before a treatment can be approved. What comes out here carries significant weight. Phase 3b Extension Study MT-1186-A04 to Evaluate the Continued Efficacy and Safety of Edaravone Oral Suspension for Up to an Additional 48 Weeks in Patients With Amyotrophic Lateral Sclerosis. (2026/04/01) ♡
- Early Dropped Head Syndrome Is More Prevalent in C9orf72 and FUS/TLS ALS. (2026/04/01) ♡
- Neurofilament Proteoforms in Amyotrophic Lateral Sclerosis Are Different in Cerebrospinal Fluid and Blood. (2026/04/01) ♡
- Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Variably Protease-Sensitive Prionopathy: Two New Cases With Motor Neuron-Dementia Syndrome. (2026/04/01) ♡
- Speech-language pathologists' confidence levels and professional development needs in motor neurone disease: An Australian survey. (2026/04/01) ♡
- Medical nutrition therapy for ALS: Dietitians' approaches to diagnosing malnutrition, facilitating feeding tube discussions, and mitigating refeeding syndrome risk. (2026/04/01) ♡
- Hippocampal Subfield Integrity and Age-Driven Neural Correlates of Appetite Loss in Amyotrophic Lateral Sclerosis. (2026/04/01) ♡
- Liver Steatosis in Induced Hepatocytes From Carriers of Spinal Muscular Atrophy. (2026/04/01) ♡
- Clinical Changes in Patients With Amyotrophic Lateral Sclerosis Admitted to a Home Care Program. (2026/04/01) ♡
- Neuroprotective Effects of Time-Restricted Feeding Combined With Different Protein Sources in MPTP-Induced Parkinson's Disease Mice Model and Its Modulatory Impact on Gut Microbiota Metabolism. (2026/04/01) ♡
- Systematic reviewiAll research on one question is searched according to fixed rules and compared side by side, so that no studies with poor outcomes are missed. Ghrelin-based interventions in preclinical models of Parkinson's disease: a systematic review. (2026/04/01) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Acupuncture: A Promising Non-Pharmacological Approach to Parkinson's Disease Management. (2026/04/01) ♡
- The economic burden of amyotrophic lateral sclerosis for patients and families: a survey on out-of-pocket expenses and income loss in France. (2026/03/31) ♡
- Systematic reviewiAll research on one question is searched according to fixed rules and compared side by side, so that no studies with poor outcomes are missed. The role of N-acetylcysteine and glutathione in the management of Parkinson's disease: a systematic review of oxidative biomarkers and clinical outcomes. (2026/03/24) ♡
- A microbiome quantitative trait locus in SLC39A8 modulates disease severity in synucleinopathy-induced models of Parkinson's disease. (2026/03/23) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Decoding Neuroinflammatory Pathways: The Role of the CXCL12-CXCR4/CXCR7 Axis in ALS-Related Cognitive Impairment. (2026/03/21) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Treating age-related loss of muscle mass and function: Where should we be focusing? (2026/03/16) ♡
- Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Investigations on the effects of SH2B2 on Parkinson's disease based on its in vivo and in vitro neurotoxic model. (2026/03/05) ♡
- Selective Silencing of TDP-43 P. G376D Mutation Reverses Key Amyotrophic Lateral Sclerosis-Related Cellular Deficits. (2026/03/05) ♡
- Aberrant nuclear pore complex degradation contributes to neurodegeneration in VCP disease. (2026/03/04) ♡
- Pharmacological activation of mitophagy antagonizes motor neuron degeneration in a cross-species platform of amyotrophic lateral sclerosis. (2026/03/01) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Motor band sign in (18)F-FDG PET/CT studies: a biomarker of degenerative upper motor neuron disease? A study of three cases and literature review. (2026/03/01) ♡
- 285th ENMC international workshop: SMN-associated neurodevelopmental disorder: type 1 spinal muscular atrophy and the brain, 31st January - 2nd February 2025, Hoofddorp, The Netherlands. (2026/03/01) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Integrative physiology of skeletal muscle for maintaining cognitive health. (2026/03/01) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Nutraceutical interventions for neuroprotection: a comprehensive review. (2026/03/01) ♡
- Changes in body composition and phase angle from diagnosis to gastrostomy, in motor neuron disease patients: a longitudinal study. (2026/03/01) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Non-invasive ventilation support during feeding tube placement in amyotrophic lateral sclerosis patients with moderate to severe ventilatory impairment: an update. (2026/03/01) ♡
- Real-world treatment patterns and unmet needs in spinal muscular atrophy: a caregiver-centric survey study from China. (2026/02/27) ♡
- [Analysis of early complications and risk factors in patients with amyotrophic lateral sclerosis after percutaneous endoscopic gastrostomy]. (2026/02/18) ♡
- Meta-analysisiAll studies on one question combined and calculated together. This is the strongest form of research that exists: a single loose study can be coincidence, dozens together much less so. The label says something about the design, not about the outcome — which can also be that something does NOT work. Prevalence and trajectories of post-COVID-19 neuromuscular conditions: A systematic-review and meta-analysis. (2026/02/15) ♡
- Microvascular pathology in the spinal cord of severe spinal muscular atrophy patients. (2026/02/15) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Spinal Muscular Atrophy. (2026/02/12) ♡
- The Sixth Annual Symposium of the Midwest Aging Consortium. (2026/02/05) ♡
- Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. An isoflavone-enriched diet alleviates Parkinson's disease in mice by inhibiting ferroptosis through gut microbiota-mediated serotonin production. (2026/02/03) ♡
- Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Behavior- and Cell Type-Specific Cortico-Striatal Decoupling in a Parkinson's Disease-Like Mouse Model. (2026/02/01) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Clinically discordant siblings with spinal muscular atrophy: insights from their patient-specific iPSC-derived motor neurons and literature review. (2026/02/01) ♡
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