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Primary lateral sclerosis

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Search Period All yearsLast 12 monthsLast 5 years Topic All topicsGeneralNutrition and dietAlternative treatment methods Type of research Any type of researchHighest evidence only (123)Meta-analysis (29)Treatment guideline (6)Systematic review (51)Randomized controlled trial (19)Phase 3 study (18)Clinical trial (658)Review article (336)Early-stage study (phase 1 or 2) (13)Laboratory or animal research (123)Case description (120)Commentary or editorial (46)Retracted publication (1) Studies currently recruiting participants only (31)

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Publications and studies (2508)

• Neuroprotective Effects of Lycopene in Parkinson's Disease Mice: Potential Modulation of DAT/SLC6A3-Mediated Dopaminergic Pathway. (2026/07/09) ♡
• Pathogenicity Classification of TARDBP Variants of Uncertain Significance: An Integrative Clinical Characterization and Functional Validation. (2026/07/08) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Reduced DJ-1/nrf2/HO-1 antioxidant signalling is associated with type 2 diabetes-related aggravation of neurodegeneration in a mouse model of Parkinson's disease. (2026/07/08) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. A Systematic Literature Review of Emerging Advances in Neurological Disorders: Diagnostic Innovations, Therapeutic Strategies, and Future Directions. (2026/07/07) ♡
• A Non-spinal Neural Circuit for Transmitting Information of Bladder Conditions. (2026/07/01) ♡
• New SMA era: A broad-range tiered assessment of function for the evolving SMA phenotype (EVOLVE-SMA). (2026/07/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Intrathecal Administration of Riluzole in Amyotrophic Lateral Sclerosis. (2026/07/01) ♡
• Impacts of oral supplementation of vitamin B12 and plasma levels of homocysteine on progression and survival in a Chinese ALS cohort. (2026/07/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Spinal muscular atrophy in India: Patient journey, access to care, treatment barriers, and strategic recommendations: Insights from experts. (2026/07/01) ♡
• Development of a Complex Intervention to Support High Calorie Diets for People With Amyotrophic Lateral Sclerosis. (2026/07/01) ♡
• Swallowing assessment in spinal muscular atrophy type 1: a real-world study of dysphagia in children receiving disease-modifying therapies. (2026/07/01) ♡
• A Retrospective Cohort Study of Nutrition Outcomes in Children With Spinal Muscular Atrophy Type 1 and 2 Treated With Disease Modifying Therapies. (2026/07/01) ♡
• The impact of long-term feeding with curcuminoids phospholipids enriched diet on disease progression of fALS. (2026/07/01) ♡
• Facial Nerve Thinning Correlates With Motor Function in Adults With Spinal Muscular Atrophy. (2026/07/01) ♡
• Elucidating the molecular mechanisms underlying the therapeutic effects of 6-shogaol on Parkinson's disease. (2026/07/01) ♡
• Systematic reviewiAll research on one question is searched according to fixed rules and compared side by side, so that no studies with poor outcomes are missed. Experimental evidence of electroacupuncture in ALS mouse models: a systematic review and meta-analysis. (2026/07/01) ♡
• Identifying Gastrostomy Care and Home Gastrostomy Tube Feeding-Related Educational Content for Patients With Amyotrophic Lateral Sclerosis and Their Family Caregivers: A Delphi Panel With Professional Stakeholders. (2026/07/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Nursing a Patient With Amyotrophic Lateral Sclerosis Stage 4B With Epilepsy: A Case Study. (2026/07/01) ♡
• Motor function score changes in severe 5q spinal muscular atrophy during risdiplam treatment: an observational longitudinal nationwide cohort study. (2026/06/30) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Trigeminal Herpes Zoster With Longitudinally Extensive Spinal Trigeminal Tract Involvement Presenting as an Isolated Facial Palsy Mimicking Ramsay Hunt Syndrome. (2026/06/30) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Targeting mtDNA to Modulate Mitochondrial Dysfunction in Neurodegenerative Diseases. (2026/06/26) ♡
• Neuroprotective Potential of Synaptamide in MPTP-Induced Parkinson's Disease. (2026/06/25) ♡
• A α-synuclein aggregation inhibitor exerts neuroprotective effects via mitochondrial resilience in Parkinson's disease. (2026/06/24) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Amyotrophic Lateral Sclerosis as a Systemic Disease: Why Integrative and Microbiome-Focused Approaches Deserve Re-Evaluation. (2026/06/24) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Cholesterol in amyotrophic lateral sclerosis: a bystander, a biomarker, or a target? (2026/06/24) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Development of Clinical Pathways for Early Diagnosis and Management of SCID, SMA, and XLA Through Newborn Screening in Malaysia. (2026/06/23) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Walking as a Window to the Brain: Redefining Gait in Neurology. (2026/06/23) ♡
• A multi-centre prospective evaluation of post-gastrostomy outcomes in patients with amyotrophic lateral sclerosis. (2026/06/23) ♡
• Perspective and quality of life in amyotrophic lateral sclerosis patients undergoing percutaneous endoscopic gastrostomy. (2026/06/19) ♡
• Meta-analysisiAll studies on one question combined and calculated together. This is the strongest form of research that exists: a single loose study can be coincidence, dozens together much less so. The label says something about the design, not about the outcome — which can also be that something does NOT work. Associations between pre-disease biomarkers of persistent organic pollutants and amyotrophic lateral sclerosis risk in four European cohorts. (2026/06/15) ♡
• [Effect of electroacupuncture at "Zusanli" (ST36) on TREM2-mediated microglial activation in amyotrophic lateral sclerosis mice]. (2026/06/12) ♡
• DIGEST Grades Remain Stable With Inclusion of Moderately Thickened Liquids in the Videofluoroscopic Examination in Individuals With Amyotrophic Lateral Sclerosis. (2026/06/10) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. DJ-1 in the Neuro-cutaneous Aging Axis: Unifying Pathways of Parkinson's Disease Neurodegeneration, Progression, and Redox-Based Therapeutic Strategies for Healthy Longevity. (2026/06/08) ♡
• Targeting α-Synuclein Aggregation in Parkinson's Disease: A Narrative Review of Current Gene Therapy Strategies. (2026/06/08) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Cholinergic neurons in the dorsal nucleus of the vagus nerve are involved in the mechanism of action of electroacupuncture at HT7 in a mouse model of chronic heart failure. (2026/06/01) ♡
• Beneficial effects of electro-acupuncture treatment in photothrombotic ischemia model rats by remodeling neurovascular unit. (2026/06/01) ♡
• Assessing the growth of children with spinal muscular atrophy using specific curves: A retrospective cohort study. (2026/06/01) ♡
• Blood Lactate as a Prognostic Biomarker for Survival and Weight Loss in Amyotrophic Lateral Sclerosis: An Exploratory-Validation Study. (2026/06/01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Comparison of Nusinersen Monotherapy Versus Combination Therapy With Nusinersen and Onasemnogene Abeparvovec in Spinal Muscular Atrophy Type 1 Patients With Two SMN2 Copies: A Multicenter Study From Türkiye. (2026/06/01) ♡
• Distinct Prescription Patterns Emerge Years Before ALS Diagnosis: A Nationwide Registry-Based Study. (2026/06/01) ♡
• Assessing green space exposure: From traditional metrics to the Green Exposure Index (GEI) with application to a Northern Italy residential dataset. (2026/06/01) ♡
• Global trends in rehabilitation needs for individuals with neurological disorders across 204 countries: data analysis from the global burden of disease study 2021. (2026/06/01) ♡
• Systematic reviewiAll research on one question is searched according to fixed rules and compared side by side, so that no studies with poor outcomes are missed. Criterion validity of equations as alternatives to reference standards for assessing body composition and energy expenditure in amyotrophic lateral sclerosis - A systematic literature review. (2026/06/01) ♡
• Treatment guidelineiAn official agreement between doctors about how this disease should be treated. This is not a single study but the conclusion of an entire medical field. Primary Lateral Sclerosis French National Diagnostic and Care Protocol. (2026/06/01) ♡
• Age-Dependent Remodeling of the Sciatic Nerve Proteome in 5xFAD Mice Can Be Attenuated by Exercise or Donepezil Treatment to Maintain Neuromuscular Function. (2026/06/01) ♡
• Association between body composition and disease progression in adults with amyotrophic lateral sclerosis: a cross-sectional study. (2026/05/30) ♡
• Green space exposure and risk of amyotrophic lateral sclerosis: a population-based case-control study in Northern Italy. (2026/05/22) ♡
• Feasibility and Tolerability of Ketogenic Interventions in Amyotrophic Lateral Sclerosis-A Dose-Finding Case Series. (2026/05/21) ♡
• The Dysphagia Outcome and Severity Scale (DOSS) and non-instrumental swallowing measures in amyotrophic lateral sclerosis. (2026/05/07) ♡
• MCHR1 in Both Dopaminergic Neurons and Astrocytes in the SNpc Contributes to Acupuncture's Anti-Parkinsonian Effects. (2026/05/06) ♡

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