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Primary lateral sclerosis
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Publications and studies (2510)
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Role of the gut microbiota in the development of various neurological diseases. (2022/07/01) ♡
- Exploring Gastrostomy Care-Related Information Needs in Patients With Amyotrophic Lateral Sclerosis and Their Families. (2022/07/01) ♡
- Resilin, an insect-derived elastomeric protein, protects dopaminergic neurons in Parkinson disease models. (2022/06/11) ♡
- Physical Therapy and Nusinersen Impact on Spinal Muscular Atrophy Rehabilitative Outcome. (2022/06/06) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. AI-based protein structure databases have the potential to accelerate rare diseases research: AlphaFoldDB and the case of IAHSP/Alsin. (2022/06/01) ♡
- Family, healthcare professional, and societal preferences for the treatment of infantile spinal muscular atrophy: A discrete choice experiment. (2022/06/01) ♡
- A time-course study of microglial activation and dopaminergic neuron loss in the substantia nigra of mice with paraquat-induced Parkinson's disease. (2022/06/01) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Emerging technologies for management of patients with amyotrophic lateral sclerosis: from telehealth to assistive robotics and neural interfaces. (2022/06/01) ♡
- Commentary or editorialiAn expert's opinion or commentary, not new research. Reply to: The 4-Copy Conundrum in the Treatment of Infants with Spinal Muscular Atrophy. (2022/06/01) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Understanding the current nutritional management for people with amyotrophic lateral sclerosis - A mapping review. (2022/06/01) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Lessons to Learn from the Gut Microbiota: A Focus on Amyotrophic Lateral Sclerosis. (2022/05/12) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. The Advent of Omics Sciences in Clinical Trials of Motor Neuron Diseases. (2022/05/07) ♡
- Mouse midbrain dopaminergic neurons survive loss of the PD-associated mitochondrial protein CHCHD2. (2022/05/04) ♡
- Mutation screening of the DNAJC7 gene in Japanese patients with sporadic amyotrophic lateral sclerosis. (2022/05/01) ♡
- Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. High fat diet-induced obesity causes a reduction in brain tyrosine hydroxylase levels and non-motor features in rats through metabolic dysfunction, neuroinflammation and oxidative stress. (2022/05/01) ♡
- Systematic reviewiAll research on one question is searched according to fixed rules and compared side by side, so that no studies with poor outcomes are missed. Percutaneous gastrostomy in amyotrophic lateral sclerosis: a review. (2022/05/01) ♡
- Predicting dysphagia onset in patients with ALS: the ALS dysphagia risk score. (2022/05/01) ♡
- Current practices and barriers in gastrostomy indication in amyotrophic lateral sclerosis: a survey of ALS care teams in The Netherlands. (2022/05/01) ♡
- Body mass index in type 2 spinal muscular atrophy: a longitudinal study. (2022/05/01) ♡
- Body composition in amyotrophic lateral sclerosis subjects and its effect on disease progression and survival. (2022/05/01) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Management of Spinal Muscular Atrophy in the Adult Population. (2022/05/01) ♡
- Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Robot-assisted training using hybrid assistive limb ameliorates gait ability in patients with amyotrophic lateral sclerosis. (2022/05/01) ♡
- Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Evaluation of real-life outcome data of patients with spinal muscular atrophy treated with nusinersen in Switzerland. (2022/05/01) ♡
- Palliative sedation in amyotrophic lateral sclerosis: results of a nationwide survey among neurologists and palliative care practitioners in Germany. (2022/04/30) ♡
- Systematic reviewiAll research on one question is searched according to fixed rules and compared side by side, so that no studies with poor outcomes are missed. Systematic and state-of the science review of the role of environmental factors in Amyotrophic Lateral Sclerosis (ALS) or Lou Gehrig's Disease. (2022/04/15) ♡
- Different sensorimotor mechanism in fast and slow progression amyotrophic lateral sclerosis. (2022/04/01) ♡
- Commentary or editorialiAn expert's opinion or commentary, not new research. Dramatic Innovations in the Treatment of Spinal Muscular Atrophy, But Many Unknowns Remain. (2022/04/01) ♡
- Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Spinal muscular atrophy with predominant lower extremity (SMA-LED) with no signs other than pure motor symptoms at the intersection of multiple overlap syndrome. (2022/04/01) ♡
- Multiple system atrophy and C9orf72 hexanucleotide repeat expansions in a cohort of Italian patients. (2022/04/01) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Embodied cognition in neurodegenerative disorders: What do we know so far? A narrative review focusing on the mirror neuron system and clinical applications. (2022/04/01) ♡
- Decreased plasma ghrelin in male ALS patients is associated with poor prognosis. (2022/04/01) ♡
- SOD-1 Variants in Amyotrophic Lateral Sclerosis: Systematic Re-Evaluation According to ACMG-AMP Guidelines. (2022/03/18) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Genetic architecture of motor neuron diseases. (2022/03/15) ♡
- A brain-to-spinal sensorimotor loop for repetitive self-grooming. (2022/03/02) ♡
- A multidimensional facial surface EMG analysis for objective assessment of bulbar involvement in amyotrophic lateral sclerosis. (2022/03/01) ♡
- Clinical profile and multidisciplinary needs of patients with neuromuscular disorders transitioning from paediatric to adult care. (2022/03/01) ♡
- Primary lateral sclerosis: diagnostic contribution of brain [(18)F]FDG PET/CT. (2022/03/01) ♡
- Curcumin and neurological diseases. (2022/03/01) ♡
- Ethical Perspectives on Treatment Options with Spinal Muscular Atrophy Patients. (2022/03/01) ♡
- Randomized researchiParticipants were divided into groups by lottery and compared with each other. This reduces the chance that a difference is due to something other than the treatment. Fat-rich versus carbohydrate-rich nutrition in ALS: a randomised controlled study. (2022/03/01) ♡
- Curcumin-Loaded Human Serum Albumin Nanoparticles Prevent Parkinson's Disease-like Symptoms in C. elegans. (2022/02/24) ♡
- Dietary-Derived Essential Nutrients and Amyotrophic Lateral Sclerosis: A Two-Sample Mendelian Randomization Study. (2022/02/22) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Multidimensional Clinical Assessment in Frontotemporal Dementia and Its Spectrum in Latin America and the Caribbean: A Narrative Review and a Glance at Future Challenges. (2022/02/16) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. The role of intra and inter-molecular disulfide bonds in modulating amyloidogenesis: A review. (2022/02/15) ♡
- Neurofilament Light Regulates Axon Caliber, Synaptic Activity, and Organelle Trafficking in Cultured Human Motor Neurons. (2022/02/14) ♡
- China amyotrophic lateral sclerosis registry of patients with Traditional Chinese Medicine (CARE-TCM): Rationale and design. (2022/02/10) ♡
- Investigation of the prognostic predictive value of serum lipid profiles in amyotrophic lateral sclerosis: roles of sex and hypermetabolism. (2022/02/03) ♡
- An ALS-associated variant of the autophagy receptor SQSTM1/p62 reprograms binding selectivity toward the autophagy-related hATG8 proteins. (2022/02/01) ♡
- Watching liquid droplets of TDP-43(CTD) age by Raman spectroscopy. (2022/02/01) ♡
- Meta-analysisiAll studies on one question combined and calculated together. This is the strongest form of research that exists: a single loose study can be coincidence, dozens together much less so. The label says something about the design, not about the outcome — which can also be that something does NOT work. Cardiovascular comorbidities in amyotrophic lateral sclerosis: A systematic review. (2022/02/01) ♡
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