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Primary lateral sclerosis
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Publications and studies (2510)
- Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. A unilateral FLAIR-hyperintense lesions in anti-MOG-associated encephalitis with seizures (FLAMES) case from a developing country: A case report. (2022/11/12) ♡
- Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Herbal medicine and acupuncture relieved progressive bulbar palsy for more than 3 years: A case report. (2022/11/11) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. The Cellular and Molecular Signature of ALS in Muscle. (2022/11/08) ♡
- Current state of research on acupuncture for the treatment of amyotrophic lateral sclerosis: A scoping review. (2022/11/03) ♡
- Clinical follow-up analysis of multidisciplinary treatment of children with spinal muscular atrophy. (2022/11/02) ♡
- Systematic reviewiAll research on one question is searched according to fixed rules and compared side by side, so that no studies with poor outcomes are missed. A Systematic Review of Caregiver Coping Strategies in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. (2022/11/01) ♡
- Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Using the ALSFRS-R in multicentre clinical trials for amyotrophic lateral sclerosis: potential limitations in current standard operating procedures. (2022/11/01) ♡
- Meta-analysisiAll studies on one question combined and calculated together. This is the strongest form of research that exists: a single loose study can be coincidence, dozens together much less so. The label says something about the design, not about the outcome — which can also be that something does NOT work. Split-hand index for amyotrophic lateral sclerosis diagnosis: A frequentist and Bayesian meta-analysis. (2022/11/01) ♡
- Role of gut microbiota-derived branched-chain amino acids in the pathogenesis of Parkinson's disease: An animal study. (2022/11/01) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Progress, development, and challenges in amyotrophic lateral sclerosis clinical trials. (2022/11/01) ♡
- Slower progression of amyotrophic lateral sclerosis with external application of a Chinese herbal plaster-The randomized, placebo-controlled triple-blinded ALS-CHEPLA trial. (2022/10/17) ♡
- Modernization of a Large Spinal Cord Injuries and Disorders Registry: The Veterans Administration Experience. (2022/10/17) ♡
- C9-ALS-Associated Proline-Arginine Dipeptide Repeat Protein Induces Activation of NLRP3 Inflammasome of HMC3 Microglia Cells by Binding of Complement Component 1 Q Subcomponent-Binding Protein (C1QBP), and Syringin Prevents This Effect. (2022/10/05) ♡
- Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Corynoxine B derivative CB6 prevents Parkinsonian toxicity in mice by inducing PIK3C3 complex-dependent autophagy. (2022/10/01) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Clinical studies in amyotrophic lateral sclerosis. (2022/10/01) ♡
- Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Brachial monomelic amyotrophy as an initial manifestation of stiff person syndrome. (2022/10/01) ♡
- ALS mutations in the TIA-1 prion-like domain trigger highly condensed pathogenic structures. (2022/09/20) ♡
- Association between dysphagia and tongue strength in patients with amyotrophic lateral sclerosis. (2022/09/01) ♡
- Systematic reviewiAll research on one question is searched according to fixed rules and compared side by side, so that no studies with poor outcomes are missed. Herbal medicine for amyotrophic lateral sclerosis: A systematic review and meta-analysis. (2022/08/31) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Update on spinal muscular atrophy treatment. (2022/08/30) ♡
- Selenoprotein P Concentrations in the Cerebrospinal Fluid and Serum of Individuals Affected by Amyotrophic Lateral Sclerosis, Mild Cognitive Impairment and Alzheimer's Dementia. (2022/08/30) ♡
- Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. [A case of amyotrophic lateral sclerosis presenting with rapid progression of respiratory deterioration due to severe obesity]. (2022/08/27) ♡
- Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. [An autopsy case report of a patient with frontotemporal dementia with motor neuron disease in totally locked-in state showing hyperosmolar hyperosmotic state]. (2022/08/27) ♡
- [Handling of drugs for administration by percutaneous endoscopic gastrostomy in patients with amyotrophic lateral sclerosis and enteral nutrition]. (2022/08/25) ♡
- Nutritional therapy in amyotrophic lateral sclerosis: protocol for a systematic review and meta-analysis. (2022/08/25) ♡
- Relationship between Dietary Total Antioxidant Capacity and the Prognosis of Amyotrophic Lateral Sclerosis. (2022/08/10) ♡
- Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Enhanced effect of combining bone marrow mesenchymal stem cells (BMMSCs) and pulsed electromagnetic fields (PEMF) to promote recovery after spinal cord injury in mice. (2022/08/03) ♡
- Synthetic Peucedanocoumarin IV Prevents α-Synuclein Neurotoxicity in an Animal Model of Parkinson's Disease. (2022/08/03) ♡
- Correlation of weight and body composition with disease progression rate in patients with amyotrophic lateral sclerosis. (2022/08/02) ♡
- SQSTM1-mediated clearance of cytoplasmic mutant TARDBP/TDP-43 in the monkey brain. (2022/08/01) ♡
- Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Drug treatments and interactions, disease progression and quality of life in ALS patients. (2022/08/01) ♡
- ALSUntangled #62: vitamin C. (2022/08/01) ♡
- Progression of Oropharyngeal Dysphagia in Amyotrophic Lateral Sclerosis: A Retrospective Cohort Study. (2022/08/01) ♡
- Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Urine specific gravity to identify and predict hydration need in ALS. (2022/08/01) ♡
- Predictors of malnutrition risk in neurodegenerative diseases: The role of swallowing function. (2022/08/01) ♡
- Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Exploring the link between Parkinson's disease and type 2 diabetes mellitus in Drosophila. (2022/08/01) ♡
- [Gastrostomy tubes in patients with amyotrophic lateral sclerosis: indications, safety and experience in a tertiary care centre]. (2022/07/16) ♡
- Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Treatment with Herbal Formula Extract in the hSOD1(G93A) Mouse Model Attenuates Muscle and Spinal Cord Dysfunction via Anti-Inflammation. (2022/07/04) ♡
- Clinical follow-up analysis of nusinersen in the disease-modifying treatment of pediatric spinal muscular atrophy. (2022/07/02) ♡
- Discriminant ability of the 3-ounce water swallow test to detect aspiration in amyotrophic lateral sclerosis. (2022/07/01) ♡
- Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Supercharged End-to-Side Anterior Interosseous to Ulnar Motor Nerve Transfer for Hirayama Disease: A Case Report. (2022/07/01) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Role of the gut microbiota in the development of various neurological diseases. (2022/07/01) ♡
- Nutrition status survey of type 2 and 3 spinal muscular atrophy in Chinese population. (2022/07/01) ♡
- Evolution of bulbar function in spinal muscular atrophy type 1 treated with nusinersen. (2022/07/01) ♡
- Survival motor neuron protein deficiency alters microglia reactivity. (2022/07/01) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Genistein: A focus on several neurodegenerative diseases. (2022/07/01) ♡
- Percutaneous endoscopic gastrostomy using the introducer method with ultra-slim endoscopy in amyotrophic lateral sclerosis patients with respiratory compromise: A safe technique. (2022/07/01) ♡
- Systematic reviewiAll research on one question is searched according to fixed rules and compared side by side, so that no studies with poor outcomes are missed. Mid- and long-term (at least 12 months) follow-up of patients with spinal muscular atrophy (SMA) treated with nusinersen, onasemnogene abeparvovec, risdiplam or combination therapies: A systematic review of real-world study data. (2022/07/01) ♡
- Phase 3 studyiResearch in a large group of patients, the final step before a treatment can be approved. What comes out here carries significant weight. Onasemnogene abeparvovec for presymptomatic infants with two copies of SMN2 at risk for spinal muscular atrophy type 1: the Phase III SPR1NT trial. (2022/07/01) ♡
- Phase 3 studyiResearch in a large group of patients, the final step before a treatment can be approved. What comes out here carries significant weight. Onasemnogene abeparvovec for presymptomatic infants with three copies of SMN2 at risk for spinal muscular atrophy: the Phase III SPR1NT trial. (2022/07/01) ♡
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