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Primary lateral sclerosis
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Publications and studies (2507)
- Genetic variants among patients with motor neuron disease in Lithuania - a retrospective single-center study. (2026/07/31) ♡
- Estimating the minimal clinically important difference of functional outcomes in spinal and bulbar muscular atrophy. (2026/07/31) ♡
- Systematic reviewiAll research on one question is searched according to fixed rules and compared side by side, so that no studies with poor outcomes are missed. Central nervous system histopathological findings in classic infantile Pompe disease: a systematic review with clinical relevance. (2026/07/31) ♡
- Pneumocephalus after deep brain stimulation in Parkinson's disease: The role of brain volume in brain shift. (2026/07/31) ♡
- Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Digital Remote Assessment of Motor and Speech Changes in Amyotrophic Lateral Sclerosis: Longitudinal Observational Study. (2026/07/30) ♡
- Retrospective analysis of spinal muscular atrophy in tunisian population: phenotypic-genotypic associations and considerations for therapeutic advancement. (2026/07/29) ♡
- Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Sumoylation profiles and mitochondrial dynamics in in vivo and in vitro models of Parkinson's disease. (2026/07/29) ♡
- Early assessment, diagnosis and treatment of Parkinsonism and Related Syndromes study (ExPRESS): a protocol for an observational study on incident parkinsonism. (2026/07/29) ♡
- Systematic reviewiAll research on one question is searched according to fixed rules and compared side by side, so that no studies with poor outcomes are missed. Suicide in neurodegenerative diseases: a systematic review. (2026/07/29) ♡
- HUWE1 targets mitochondria via RMC1 to promote neurodevelopment. (2026/07/28) ♡
- Diagnostic Code Ambiguity and Misclassification of Adults With Spinal Muscular Atrophy: Single-Center Chart Review. (2026/07/28) ♡
- Tofersen treatment in respiratory onset amyotrophic lateral sclerosis and a variant of uncertain significance in SOD1; a case report. (2026/07/28) ♡
- Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Subacute Exposure to Macrocyclic Lactone Insecticides Induces Parkinson's Disease-like Motor Deficits and Neuropathology in Mice. (2026/07/28) ♡
- Clinical genome sequencing in neurodegenerative diseases-outcome in the first 500 patients. (2026/07/28) ♡
- Huoling Shengji granule in amyotrophic lateral sclerosis: A multicenter, randomized, double-blind, riluzole-controlled trial. (2026/07/27) ♡
- Longitudinal plasma proteomics predict phenoconversion to clinically manifest ALS. (2026/07/27) ♡
- Plasma cardiac troponin T complements neurofilament light chain by reflecting disease phase and phenotypic variation in amyotrophic lateral sclerosis. (2026/07/27) ♡
- Tofersen Treatment in SOD1-ALS: Real-World Evidence from a Retrospective Multicenter Study in France (FORSLA Study). (2026/07/27) ♡
- Meta-analysisiAll studies on one question combined and calculated together. This is the strongest form of research that exists: a single loose study can be coincidence, dozens together much less so. The label says something about the design, not about the outcome — which can also be that something does NOT work. Proteome-wide Mendelian randomization identifies causal plasma proteins in frontotemporal dementia. (2026/07/25) ♡
- Focal epilepsy expands the phenotype of FUS-associated amyotrophic lateral sclerosis. (2026/07/25) ♡
- The "Shoe Tip Sign" in Upper Motor Neuron Dysfunction. (2026/07/25) ♡
- Targeting DYNC1I1 attenuates Parkinsonian neurodegeneration and α-synuclein accumulation in cellular and mouse models. (2026/07/24) ♡
- A systematic review and meta-analysis of OCT-based ophthalmic changes in amyotrophic lateral sclerosis. (2026/07/24) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Psychiatric disorders in amyotrophic lateral sclerosis: a short note. (2026/07/23) ♡
- Longitudinal spinal cord MRI in adult 5q-SMA: biomarker and pathophysiological insights. (2026/07/23) ♡
- Troponin T and Neurofilament Light Chain Levels as Complementary Biomarkers of Disease Accumulation and Aggressiveness in Amyotrophic Lateral Sclerosis. (2026/07/23) ♡
- Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Parental Lifetime PBSA Exposure Induces Neurodevelopmental Toxicity in F1 Zebrafish. (2026/07/22) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Oxidative stress as a driver of organelle cascade damage in neurological diseases. (2026/07/22) ♡
- Simultaneous Detection of SMN1, SMN2, NAIP, H4F5, and GTF2H2 Copy Numbers and SMN1 Loss-of-Function Variants for SMA by MALDI-TOF Mass Spectrometry. (2026/07/21) ♡
- Treatment guidelineiAn official agreement between doctors about how this disease should be treated. This is not a single study but the conclusion of an entire medical field. French guidelines for post-polio syndrome and management of effects of aging in people with sequelae of acute anterior poliomyelitis. (2026/07/21) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. The centrosome-cilium-centriolar satellite axis in neurodegenerative diseases. (2026/07/21) ♡
- Quantitative Analysis of Timed Up and Go Metrics Across Parkinson's Disease Severity and Their Clinical Correlations. (2026/07/21) ♡
- Correction: A rare missense variant impacting NEK1 kinase function is associated with ALS. (2026/07/20) ♡
- The burden of noncommunicable and injury-related nervous system disorders in the Americas, 1990-2023: an analysis of the Global Burden of Disease Study 2023. (2026/07/20) ♡
- Brain Morphological Alterations in Adults with Spinal Muscular Atrophy Types 2 and 3: A CAT12-Derived Region-Based and Surface-Based Morphometry Study. (2026/07/20) ♡
- Microscale dysfunction and mesoscale compensation in degenerating neuronal networks. (2026/07/20) ♡
- Serum UCHL-1, GFAP, and NfL track tyrosine hydroxylase loss in substantia nigra in two Rat Models of Parkinson's Disease. (2026/07/20) ♡
- Commentary or editorialiAn expert's opinion or commentary, not new research. F waves as a measure of enhanced spinal motoneuron excitability in primary lateral sclerosis. (2026/07/18) ♡
- Lactobacillus reuteri DSM 17938 and Its Supernatant Ameliorate Parkinson's Disease in Association with Modulation of Gut Microbiota and Its Tryptophan Metabolism. (2026/07/16) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. The Kynurenine Pathway: Unraveling Its Role in Neurological Disorders via Mammalian Cellular Models. (2026/07/16) ♡
- Metabolomic analyses of amyotrophic lateral sclerosis, muscle cramps, and TJ-68 treatment. (2026/07/16) ♡
- Functional constraint, not evolutionary domain expansion, is a stronger correlate of pathogenic variant burden in human RNA-binding proteins. (2026/07/15) ♡
- A modified frailty index to identify high-risk groups for amyotrophic lateral sclerosis. (2026/07/15) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. LINE-1 Retrotransposons and Amyotrophic Lateral Sclerosis. (2026/07/14) ♡
- α-Synuclein pathology differentially alters T-type calcium currents in vulnerable and resilient substantia nigra dopaminergic subpopulations. (2026/07/14) ♡
- Strenuous physical activity is associated with a younger age of amyotrophic lateral sclerosis onset in two independent cohorts. (2026/07/13) ♡
- NPC1 deficiency engages a lysosome-genome-immune program linked to neurodegeneration and cellular aging signatures. (2026/07/13) ♡
- In APP/PS-1 Transgenic Mice and Aβ-Induced P12 Cell Models, ADCYAP1 Inhibits Neuronal Apoptosis and Autophagy, Thereby Alleviating The Pathology of Alzheimer's Disease. (2026/07/11) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Mechanisms of neurotoxicity of fluoride or aluminum: implications for neurodegenerative disease risk. (2026/07/10) ♡
- Neuroprotective Effects of Lycopene in Parkinson's Disease Mice: Potential Modulation of DAT/SLC6A3-Mediated Dopaminergic Pathway. (2026/07/09) ♡
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