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Primary lateral sclerosis

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Search Period All yearsLast 12 monthsLast 5 years Topic All topicsGeneralNutrition and dietAlternative treatment methods Type of research Any type of researchHighest evidence only (123)Meta-analysis (29)Treatment guideline (6)Systematic review (51)Randomized controlled trial (19)Phase 3 study (18)Clinical trial (658)Review article (336)Early-stage study (phase 1 or 2) (13)Laboratory or animal research (123)Case description (120)Commentary or editorial (46)Retracted publication (1) Studies currently recruiting participants only (31)

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Publications and studies (2508)

• Association between Onodera's prognostic nutritional Index and ultrasound-measured muscle thickness in amyotrophic lateral sclerosis: a retrospective cross-sectional study. (2025/12/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Dietary modulation of the gut microbiome as a supportive strategy in the treatment of amyotrophic lateral sclerosis - a narrative review. (2025/12/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. The ketogenic diet in Parkinson's disease: a potential therapeutic strategy. (2025/12/01) ♡
• Longitudinal evaluation of fatigue in adult patients with spinal muscular atrophy and the impact of disease-modifying drugs. (2025/12/01) ♡
• Increase in Ia Afferent Synaptic Excitation of SOD1 G93A Mouse Motoneurons by 2-Week Anodal Trans-Spinal Direct Current Stimulation Does Not Ameliorate the Cellular Burden of the Disease. (2025/12/01) ♡
• A Mutation in Vesicular Acetylcholine Transporter Increases Tubulin Acetylation Compromising Synaptic Vesicle Transport. (2025/12/01) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Short-Chain Fatty Acids Enhance EAAT2-Mediated Glutamate Clearance and Alleviate Oxidative Stress in an MPTP Mouse Model of Parkinson's Disease. (2025/11/27) ♡
• Human Mutant Dynactin Subunit 1 Causes Profound Motor Neuron Disease Consistent with Possible Mechanisms Involving Axonopathy, Mitochondriopathy, Protein Nitration, and T-Cell-Mediated Cytolysis. (2025/11/21) ♡
• Fiberoptic endoscopic evaluation of swallowing in amyotrophic lateral sclerosis: comparison with older people with dysphagia and relationship with time since diagnosis. (2025/11/17) ♡
• Loss of C9orf72 impacts the peripheral neuromuscular system via immune dysregulation and accelerates the progression of amyotrophic lateral sclerosis in SOD-1 mutant mice. (2025/11/15) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Molecular mechanisms by which mitochondrial dysfunction drives neuromuscular junction degeneration in amyotrophic lateral sclerosis. (2025/11/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Hidden players in the metabolic vulnerabilities of amyotrophic lateral sclerosis. (2025/11/01) ♡
• Type 2 diabetes mellitus, antidiabetics, and the risk of amyotrophic lateral sclerosis. (2025/11/01) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy. (2025/11/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. CORTICOBASAL SYNDROME PRESENTING AS A PROGRESSIVE HEMIPARETIC SYNDROME: A CASE REPORT. (2025/11/01) ♡
• Predictors of Percutaneous Endoscopic Gastrostomy-Related Complications in Amyotrophic Lateral Sclerosis: A 19-Year Retrospective Study From a Tertiary Center. (2025/11/01) ♡
• [Heterogeneity in the regulation of cellular stress responses by FUS gene mutations associated with amyotrophic lateral sclerosis]. (2025/10/28) ♡
• Dietary Vitamin Intake and Blood Biomarkers in Relation to Muscle Activation in Amyotrophic Lateral Sclerosis: A Cross-Sectional Study. (2025/10/24) ♡
• Duration of Current Statin Use and Amyotrophic Lateral Sclerosis Risk: A Norwegian Population-Based Cohort Study. (2025/10/21) ♡
• Differences in swallowing efficacy of disease modifying treatment between infants receiving pre-symptomatic and symptomatic administration. (2025/10/21) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. The Other Side of the Same Coin: Beyond the Coding Region in Amyotrophic Lateral Sclerosis. (2025/10/18) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Gut-brain axis and Parkinson's disease: navigating the microbial enigma. (2025/10/17) ♡
• A guide to selecting high-performing antibodies for Optineurin (UniProt ID: Q96CV9) for use in western blot, immunoprecipitation, and immunofluorescence. (2025/10/17) ♡
• TREM2 mediates parkinsonism-like neurodegeneration in carbon disulfide-induced neurotoxicity. (2025/10/15) ♡
• MiR-140-3p regulates axonal motor protein KIF5A and contributes to axonal transport degeneration in SMA. (2025/10/07) ♡
• RES-MND: Motor neuron disease detection using Res4Net-convolutional block attention module. (2025/10/03) ♡
• A Freely Moving Photothrombotic Stroke Model Reveals Sustained Dysfunction of GABAergic Neuron in Contralesional Cortex Using Miniaturized Two-Photon Microscopy. (2025/10/01) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Evaluation of Neuroprotective and Neuroregenerative Potential of NeuroAiD™ II(MLC901) in a Rat Model of Kainic Acid-Induced Spinal Cord Injury. (2025/10/01) ♡
• Glucose restriction induces degeneration of neurons with mitochondrial DNA depletion by altering ER-mitochondria calcium transfer. (2025/10/01) ♡
• Two-step Mendelian randomization reveals a lipid-driven protective effect of type 2 diabetes on ALS. (2025/10/01) ♡
• Randomized researchiParticipants were divided into groups by lottery and compared with each other. This reduces the chance that a difference is due to something other than the treatment. Optimising Calorie Intake for People With Amyotrophic Lateral Sclerosis: A Process Evaluation of a Complex Behaviour Change Intervention. (2025/10/01) ♡
• The Leeds Motor Neuron Disease Percutaneous Endoscopic Gastrostomy Pathway: Improving Clinical Outcomes and Experience in a UK Center. (2025/10/01) ♡
• Predicting Amyotrophic Lateral Sclerosis Mortality With Machine Learning in Diverse Patient Databases. (2025/10/01) ♡
• Comparative Clinical Outcomes of Nusinersen and Gene Therapy in Spinal Muscular Atrophy Type 1. (2025/10/01) ♡
• Impact of weight loss and disease progression on survival in ALS: insights from a multidisciplinary care center. (2025/10/01) ♡
• Analysis of factors influencing sleep disorders in patients with amyotrophic lateral sclerosis. (2025/09/30) ♡
• Short-Chain Fatty Acid Profiles in Amyotrophic Lateral Sclerosis: Longitudinal Effects of Disease and Mediterranean Diet Intervention. (2025/09/28) ♡
• Electroacupuncture Regulates Mitochondria-Endoplasmic Reticulum interactions via Fn1 in a Parkinson's Disease Model: Transcriptomic Evidence. (2025/09/18) ♡
• Progression and life expectancy in primary lateral sclerosis. (2025/09/12) ♡
• Biodegradable, electroconductive self-healing hydrogel based on polydopamine-coated polyurethane nano-crosslinker for Parkinson's disease therapy. (2025/09/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Advanced nutraceutical approaches to Parkinson's disease: bridging nutrition and neuroprotection. (2025/09/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Comparison of Superoxide Dismutase Activity at the Cell, Organ, and Whole-Body Levels. (2025/09/01) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Behavioural effects of oral cannabidiol (CBD) treatment in the superoxide dismutase 1 G93 A (SOD1(G93 A)) mouse model of amyotrophic lateral sclerosis. (2025/09/01) ♡
• A Validated Model to Predict Severe Weight Loss in Amyotrophic Lateral Sclerosis. (2025/09/01) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. A Slower-Progressing TDP-43 rNLS8 Mouse Model for ALS: Implications for Preclinical and Mechanistic Studies. (2025/08/18) ♡
• Early-stage study (phase 1 or 2)iEarly research in a small group, primarily aimed at safety and dosage. Whether it actually works still needs to be determined afterward. Risdiplam in Presymptomatic Spinal Muscular Atrophy. (2025/08/14) ♡
• Difficulties of Eating and Masticating Solid Food in Children with Spinal Muscular Atrophy-Preliminary Study. (2025/08/06) ♡
• Effectiveness of a Learning Pathway on Food and Nutrition in Amyotrophic Lateral Sclerosis. (2025/08/06) ♡
• Association of UNC13A with increased amyotrophic lateral sclerosis risk, bulbar onset, and lower motor neuron involvement in a Norwegian ALS cohort. (2025/08/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. ALSUntangled #78: Zinc. (2025/08/01) ♡

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