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Alpha-1 antitrypsin deficiency

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Search Period All yearsLast 12 monthsLast 5 years Topic All topicsGeneralNutrition and dietAlternative treatment methods Type of research Any type of researchHighest Level of Evidence Only (35)Meta-analysis (8)Treatment guideline (5)Phase 3 study (8)Randomized trial (8)Systematic review (6)Clinical Trial (169)Review article (176)Early study (phase 1 or 2) (18)Case report (114)Laboratory or animal study (26)Commentary or editorial (90)Retracted publication (1) Only studies currently recruiting participants (28)

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Publications and studies (1172)

• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. In vitro and in vivo modulation of NADPH oxidase activity and reactive oxygen species production in human neutrophils by α(1)-antitrypsin. (2021/12/06) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Transcriptomics of bronchoalveolar lavage cells identifies new molecular endotypes of sarcoidosis. (2021/12/02) ♡
• Relationship between alpha-1 antitrypsin deficiency and obstructive sleep apnea. (2021/12/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. [MDR tuberculosis, Alpha-1-anti-trypsin Deficiency, Cough in a Geriatric Nurse]. (2021/12/01) ♡
• Relationship between Depression and Anxiety, Health Status and Lung Function in Patients with Alpha-1 Antitrypsin Deficiency. (2021/12/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Exosomes in chronic respiratory diseases. (2021/12/01) ♡
• Chronic Type A Aortic Dissection Repair in a Double Lung Transplant Recipient. (2021/12/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Abnormal liver enzymes: A review for clinicians. (2021/11/27) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. The emerging role of proteases in α(1)-antitrypsin deficiency and beyond. (2021/11/22) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Protein Misfolding and Aggregation: The Relatedness between Parkinson's Disease and Hepatic Endoplasmic Reticulum Storage Disorders. (2021/11/18) ♡
• Alternative poly-adenylation modulates α1-antitrypsin expression in chronic obstructive pulmonary disease. (2021/11/16) ♡
• Nascent chains can form co-translational folding intermediates that promote post-translational folding outcomes in a disease-causing protein. (2021/11/08) ♡
• Adenine base editing reduces misfolded protein accumulation and toxicity in alpha-1 antitrypsin deficient patient iPSC-hepatocytes. (2021/11/03) ♡
• Investigating the Link between Alpha-1 Antitrypsin Deficiency and Abdominal Aortic Aneurysms. (2021/11/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Alpha 1 Antitrypsin Therapy in Patients with Alpha 1 Antitrypsin Deficiency: Perspectives from a Registry Study and Practical Considerations for Self-Administration During the COVID-19 Pandemic. (2021/11/01) ♡
• The need for continuous quality assessment for providing optimal comprehensive care for patients with alpha-1 antitrypsin deficiency. (2021/11/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Current trends in candidate selection, contraindications, and indications for lung transplantation. (2021/11/01) ♡
• IntraIndividual Variability in Serum Alpha-1 Antitrypsin Levels. (2021/10/28) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Hypertransaminasemia and liver fibrosis associated with haptoglobin retention and anhaptoglobinemia in a paediatric patient. (2021/10/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. SERPINA1, generalized pustular psoriasis, and adult-onset immunodeficiency. (2021/10/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. A 70-Year-Old Man With Cough and Recurrent Respiratory Infections. (2021/10/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. First presentation of portal hypertension complicated by hepatopulmonary syndrome. (2021/09/20) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Estimated Prevalence and Number of PiMZ Genotypes of Alpha-1 Antitrypsin in Seventy-Four Countries Worldwide. (2021/09/17) ♡
• Association between circulating alpha-1 antitrypsin polymers and lung and liver disease. (2021/09/15) ♡
• Alpha-1 Antitrypsin Z Variant (AAT PI*Z) as a Risk Factor for Intrahepatic Cholestasis of Pregnancy. (2021/09/07) ♡
• A Particular SORL1 Micro-haplotype May Prevent Severe Liver Disease in a French Cohort of Alpha 1-Antitrypsin-deficient Children. (2021/09/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Is the diagnostic rate for the common subtypes of A1AT deficiency consistent across two Canadian Provinces? (2021/09/01) ♡
• Insights into the potential role of alpha1-antitrypsin in COVID-19 patients: Mechanisms, current update, and future perspectives. (2021/09/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Living with the enemy: from protein-misfolding pathologies we know, to those we want to know. (2021/09/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Pulmonary transplantation of alpha-1 antitrypsin (AAT)-transgenic macrophages provides a source of functional human AAT in vivo. (2021/09/01) ♡
• Quantitative (18)F-fluorodeoxyglucose positron emission tomography/computed tomography to assess pulmonary inflammation in COPD. (2021/08/31) ♡
• Long-term effect of α(1)-antitrypsin augmentation therapy on the decline of FEV(1) in deficient patients: an analysis of the AIR database. (2021/08/23) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. In Vitro Investigations on Optimizing and Nebulization of IVT-mRNA Formulations for Potential Pulmonary-Based Alpha-1-Antitrypsin Deficiency Treatment. (2021/08/17) ♡
• Quantitative measurement of the histological features of alpha-1 antitrypsin deficiency-associated liver disease in biopsy specimens. (2021/08/16) ♡
• The Induction of Alpha-1 Antitrypsin by Vitamin D in Human T Cells Is TGF-β Dependent: A Proposed Anti-inflammatory Role in Airway Disease. (2021/08/12) ♡
• Alpha-1 Antitrypsin Augmentation Inhibits Proteolysis of Neutrophil Membrane Voltage-Gated Proton Channel-1 in Alpha-1 Deficient Individuals. (2021/08/10) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. The spectrum of Epstein-Barr virus infections of the central nervous system after organ transplantation. (2021/08/06) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. How Do Mechanics Guide Fibroblast Activity? Complex Disruptions during Emphysema Shape Cellular Responses and Limit Research. (2021/08/05) ♡
• SARS-CoV-2 infection in alpha1-antitrypsin deficiency. (2021/08/01) ♡
• Transient Elastography in Pediatric Liver Disease. (2021/08/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Concomitant congenital CMV infection and inherited liver diseases. (2021/08/01) ♡
• COVID-19 vaccination in patients with α1-antitrypsin deficiency. (2021/08/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Alpha1-antitrypsin deficiency: New therapies on the horizon. (2021/08/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Liver disease with unknown etiology - have you ruled out alpha-1 antitrypsin deficiency? (2021/07/29) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. The spectrum of clinical sequelae associated with alpha-1 antitrypsin deficiency. (2021/07/29) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Lung and liver transplantation in patients with alpha-1 antitrypsin deficiency. (2021/07/29) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Management of lung disease in alpha-1 antitrypsin deficiency: what we do and what we do not know. (2021/07/29) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Alpha-1 antitrypsin deficiency research and emerging treatment strategies: what's down the road? (2021/07/29) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Variants of SERPINA1 and the increasing complexity of testing for alpha-1 antitrypsin deficiency. (2021/07/29) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Imaging in alpha-1 antitrypsin deficiency: a window into the disease. (2021/07/29) ♡

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