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Alpha-1 antitrypsin deficiency

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Search Period All yearsLast 12 monthsLast 5 years Topic All topicsGeneralNutrition and dietAlternative treatment methods Type of research Any type of researchHighest Level of Evidence Only (35)Meta-analysis (8)Treatment guideline (5)Phase 3 study (8)Randomized trial (8)Systematic review (6)Clinical Trial (169)Review article (176)Early study (phase 1 or 2) (18)Case report (114)Laboratory or animal study (26)Commentary or editorial (90)Retracted publication (1) Only studies currently recruiting participants (28)

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Publications and studies (1172)

• Cognitive Difficulties and Health-Related Quality of Life in Sarcoidosis: An Analysis of the GRADS Cohort. (2022/06/22) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Feasibility of a genotyping system for the diagnosis of alpha1 antitrypsin deficiency: a multinational cross-sectional analysis. (2022/06/10) ♡
• Thrombotic risk determined by rare and common SERPINA1 variants in a population-based cohort study. (2022/06/01) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. The Null Q0(Ourém) Variant within a Copy-Neutral Loss-of-Heterozygosity Event Causing Alpha-1 Antitrypsin Deficiency. (2022/06/01) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Cytokine Regulation by Alpha-1 Antitrypsin Therapy: A Pathway Analysis of a Pilot Clinical Trial. (2022/06/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Developing lung cancer in COPD: Possible role of carrying Alpha-1 antitrypsin deficiency variants. (2022/05/21) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Fragments of alpha-1-antitrypsin in patients with severe COVID-19 and bacterial pulmonary sepsis. (2022/05/04) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Cystic fibrosis and alpha-1 antitrypsin deficiency: case report and review of literature. (2022/05/03) ♡
• d-Galactose treatment increases ACE2, TMPRSS2, and FURIN and reduces SERPINA1 mRNA expression in A549 human lung epithelial cells. (2022/05/01) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Effects of ABCG1 knockout on proteomic composition of HDL in mice on a chow diet and a high-fat diet. (2022/05/01) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Is the determination of C-reactive protein really necessary in the diagnosis of Alpha-1 antitrypsin deficiency? (2022/05/01) ♡
• [Could it Be the Deficiency of Alpha-1 Antitrypsin a Protective Factor Against Arterial Hypertension and Ischemic Heart Disease?]. (2022/04/29) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. How are we in Brazil with the treatment of alpha-1 antitrypsin deficiency? (2022/04/29) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Segmental endobronchial valve therapy for a vasculitis-induced emphysema. (2022/04/16) ♡
• Liver-directed SERPINA1 gene therapy attenuates progression of spontaneous and tobacco smoke-induced emphysema in α1-antitrypsin null mice. (2022/04/13) ♡
• Hepatic decompensation is accelerated in patients with cirrhosis and alpha-1 antitrypsin Pi∗MZ genotype. (2022/04/05) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Alpha-1 antitrypsin deficiency: A re-surfacing adult liver disorder. (2022/04/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Alpha-1-Antitrypsin Deficiency. (2022/03/27) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Azygos Vein Central Venous Access in a Patient with Thoracic Central Venous Obstruction. (2022/03/01) ♡
• Sensitive and specific measurement of alpha(1)-antitrypsin activity with an elastase complex formation immunosorbent assay (ECFISA). (2022/02/05) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Alpha-1 antitrypsin deficiency-associated panniculitis: A potentially challenging diagnosis but an important one for patients. (2022/02/01) ♡
• Prevalence of Alpha-1 Antitrypsin Deficiency, Self-Reported Behavior Change, and Health Care Engagement Among Direct-to-Consumer Recipients of a Personalized Genetic Risk Report. (2022/02/01) ♡
• Hepatobiliary phenotypes of adults with alpha-1 antitrypsin deficiency. (2022/02/01) ♡
• Production and characterization of mono-PEGylated alpha-1 antitrypsin for augmentation therapy. (2022/01/25) ♡
• Alpha-1 antitrypsin deficiency is significantly associated with atopy in asthmatic patients. (2022/01/01) ♡
• Matrix metalloproteinase-13 is fully activated by neutrophil elastase and inactivates its serpin inhibitor, alpha-1 antitrypsin: Implications for osteoarthritis. (2022/01/01) ♡
• Treatment guidelineiAn official agreement between doctors about how this disease should be treated. This is not a single study but the conclusion of an entire medical field. Non-invasive diagnosis and follow-up of rare genetic liver diseases. (2022/01/01) ♡
• α(1) -Antitrypsin Z allele and risk of venous thromboembolism in the general population. (2022/01/01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Neurodevelopmental Outcomes in Children With Inherited Liver Disease and Native Liver. (2022/01/01) ♡
• Distribution of the Clinical Manifestations of Alpha 1 Antitrypsin Deficiency in Respiratory Outpatients from an Area of Northern Italy. (2022/01/01) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Response to "AAT deficiency: PI*Mpalermo and PI*Siiyama, current diagnosis and future risk". (2022/01/01) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Alpha-1 antitrypsin deficiency: PI*M(palermo) and PI*S(iiyama) , current damage and future risk. (2022/01/01) ♡
• Proteolysis and Deficiency of α1-Proteinase Inhibitor in SARS-CoV-2 Infection. (2022/01/01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Effects of Pulmonary Rehabilitation on Skeletal Muscle in COPD Patients (2022-11-30) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Maternal alpha1 Antitrypsin as a Marker of Intrauterine Growth Restriction in Pre-eclamptic Women (2022-11-22) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Oxidoreductive Balance and Lysosomal Activity in Cancer Patients. (2022-09-28) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. A Single Ascending and Repeated Dose Study of Oral ZF874 in Healthy Volunteers and PiXZ Subjects (2022-09-19) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Phase 1 Study to Assess the Safety, PK and PD of INBRX-101 in Adults With Alpha-1 Antitrypsin Deficiency (2022-09-13) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Endoscopic Lung Volume Reduction in Patients With Advanced Emphysema Due to alpha1 Antitrypsin Deficiency (2022-08-30) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Evaluation of the Efficacy and Safety of VX-864 in Subjects With the PiZZ Genotype (2022-05-26) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Functional and Structural Lung Imaging in Chronic Obstructive Pulmonary Disease (2022-05-24) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. An Observational Study Evaluating Patients With Chronic Liver Diseases Associated With Hepatic Steatosis (2022-04-19) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. A 12-week Study Treating Participants Who Have alpha1-antitrypsin-related COPD With Alvelestat (MPH966) or Placebo. (2022-04-14) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Long-term Safety of Alpha1-Proteinase Inhibitor (Human) in Japanese Subjects With Alpha1 Antitrypsin Deficiency (GTI1401-OLE) (2022-03-31) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Evaluation of the Efficacy and Safety of VX-814 in Subjects With the PiZZ Genotype (2022-02-02) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Czech AATD Registry (2022-01-05) ♡
• Lung Function and Health Status in Individuals with Severe Alpha-1-Antitrypsin Deficiency at the Age of 42. (2021/12/23) ♡
• HRD1-mediated METTL14 degradation regulates m(6)A mRNA modification to suppress ER proteotoxic liver disease. (2021/12/16) ♡
• C3d Elicits Neutrophil Degranulation and Decreases Endothelial Cell Migration, with Implications for Patients with Alpha-1 Antitrypsin Deficiency. (2021/12/16) ♡
• The Mechanism of Mitochondrial Injury in Alpha-1 Antitrypsin Deficiency Mediated Liver Disease. (2021/12/09) ♡

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