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Alpha-1 antitrypsin deficiency

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Search Period All yearsLast 12 monthsLast 5 years Topic All topicsGeneralNutrition and dietAlternative treatment methods Type of research Any type of researchHighest Level of Evidence Only (35)Meta-analysis (8)Treatment guideline (5)Phase 3 study (8)Randomized trial (8)Systematic review (6)Clinical Trial (169)Review article (176)Early study (phase 1 or 2) (18)Case report (114)Laboratory or animal study (27)Commentary or editorial (90)Retracted publication (1) Only studies currently recruiting participants (28)

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Publications and studies (1173)

• A stacking ensemble machine learning model to predict alpha-1 antitrypsin deficiency-associated liver disease clinical outcomes based on UK Biobank data. (2022/10/11) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Acute Disseminated Panniculitis Associated with Alpha-1 Antitrypsin Deficiency. (2022/10/06) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. [Alpha 1-antitrypsin deficiency]. (2022/10/01) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Alpha-1 Antitrypsin Deficiency Severe and No Severe. Is It Benefit or Risk? (2022/10/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Novel insights into the relationship between α-1 anti-trypsin with the pathological development of cardio-metabolic disorders. (2022/10/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Alpha1-antitrypsin deficiency and cardiovascular disease: questions and issues of a debated relation. (2022/10/01) ♡
• Meta-analysisiAll studies on one question combined and calculated together. This is the strongest form of research that exists: a single loose study can be coincidence, dozens together much less so. The label says something about the design, not about the outcome — which can also be that something does NOT work. Unique and shared systemic biomarkers for emphysema in Alpha-1 Antitrypsin deficiency and chronic obstructive pulmonary disease. (2022/10/01) ♡
• Frequency of alpha-1 antitrypsin deficiency and unexpected results in COPD patients in Turkey; rare variants are common. (2022/10/01) ♡
• Indirect effect of alpha-1-antitrypsin on endotoxin-induced IL-1β secretion from human PBMCs. (2022/09/30) ♡
• Demographic and clinical characteristics of patients with α(1)-antitrypsin deficiency genotypes PI*ZZ and PI*SZ in the Spanish registry of EARCO. (2022/09/26) ♡
• Global 5'-UTR RNA structure regulates translation of a SERPINA1 mRNA. (2022/09/23) ♡
• Orphan drug development in alpha-1 antitypsin deficiency. (2022/09/15) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Augmentation therapy with human alpha-1-proteinase inhibitor reduces exacerbations in patient with bronchiectasis and alpha-1-antitrypsin deficiency. (2022/09/14) ♡
• Molecular characterization of PI (*) S (hangzhou) , a SERPINA1 allele from continental China encoding a defective alpha-1-antitrypsin. (2022/09/14) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Usefulness of the "La palma" diagnostic algorithm in the alpha-1 antitrypsin deficiency. (2022/09/09) ♡
• Correlation of alpha-1 antitrypsin levels and exosome associated neutrophil elastase endothelial injury in subjects with SARS-CoV2 infection. (2022/09/09) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Loss of Serpina1 in Mice Leads to Altered Gene Expression in Inflammatory and Metabolic Pathways. (2022/09/09) ♡
• Cigarette smoke exposed airway epithelial cell-derived EVs promote pro-inflammatory macrophage activation in alpha-1 antitrypsin deficiency. (2022/09/06) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Pregnancy in patients with Alpha 1 Antitrypsin (AAT) deficiency and the role of intravenous AAT therapy. Authors' reply. (2022/09/01) ♡
• High-level production of wild-type and oxidation-resistant recombinant alpha-1-antitrypsin in glycoengineered CHO cells. (2022/09/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Alpha-1 Asthma Overlap Syndrome: a Clinical Overview. (2022/09/01) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. The unfolded protein response to PI*Z alpha-1 antitrypsin in human hepatocellular and murine models. (2022/09/01) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. [Alpha1-antitrypsin deficiency: French guidelines… at last !]. (2022/09/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Alpha-1 antitrypsin in autoimmune diseases: Roles and therapeutic prospects. (2022/09/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Alpha-1 antitrypsin: A novel biomarker and potential therapeutic approach for metabolic diseases. (2022/09/01) ♡
• Suggestions for a New Clinical Classification Approach to Panniculitis Based on a Mayo Clinic Experience of 207 Cases. (2022/09/01) ♡
• Nanomedicine platform for targeting activated neutrophils and neutrophil-platelet complexes using an α(1)-antitrypsin-derived peptide motif. (2022/09/01) ♡
• Treatment guidelineiAn official agreement between doctors about how this disease should be treated. This is not a single study but the conclusion of an entire medical field. [French clinical practice guidelines for the diagnosis and management of lung disease with alpha 1-antitrypsin deficiency]. (2022/09/01) ♡
• Pharmacokinetics and Biochemical Efficacy of an α(1)-Proteinase Inhibitor (Aralast NP) in α(1)-Antitrypsin Deficiency: a Cross-Product Retrospective Comparability Analysis. (2022/09/01) ♡
• Keratin 8 is a scaffolding and regulatory protein of ERAD complexes. (2022/09/01) ♡
• Development of peptide ligands for the purification of α-1 antitrypsin from cell culture fluids. (2022/08/30) ♡
• Improving the Laboratory Diagnosis of M-like Variants Related to Alpha1-Antitrypsin Deficiency. (2022/08/30) ♡
• Alpha-1 antitrypsin Pi∗Z allele is an independent risk factor for liver transplantation and death in patients with advanced chronic liver disease. (2022/08/20) ♡
• Early-stage study (phase 1 or 2)iEarly research in a small group, primarily aimed at safety and dosage. Whether it actually works still needs to be determined afterward. Fazirsiran for Liver Disease Associated with Alpha(1)-Antitrypsin Deficiency. (2022/08/11) ♡
• Secretion of functional α1-antitrypsin is cell type dependent: Implications for intramuscular delivery for gene therapy. (2022/08/02) ♡
• Disease progression in patients with PI*ZZ alpha-1 antitrypsin deficiency. (2022/08/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Alpha-1 Antitrypsin Deficiency Liver Disease. (2022/08/01) ♡
• Occupational and environmental exposures in the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) study. (2022/08/01) ♡
• Assessing Patients with Alpha-1 Antitrypsin Deficiency for Corneal Refractive Surgery: A Review and Clinical Experience. (2022/07/19) ♡
• Identification of Pathogenic Variant Burden and Selection of Optimal Diagnostic Method Is a Way to Improve Carrier Screening for Autosomal Recessive Diseases. (2022/07/12) ♡
• Whole exome sequencing in a juvenile idiopathic arthritis large family with SERPINA1 gene mutations. (2022/07/04) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Alpha-1 Antitrypsin Reduces Disease Progression in a Mouse Model of Charcot-Marie-Tooth Type 1A: A Role for Decreased Inflammation and ADAM-17 Inhibition. (2022/07/03) ♡
• Alpha-1 antitrypsin deficiency hidden in allegedly normal variants. (2022/07/01) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. A Role for Hepatic Insulin Signaling in α1-Antitrypsin Deficiency. (2022/07/01) ♡
• Alpha-1 Antitrypsin Therapy Modifies Neutrophil Adhesion in Patients with Obstructive Lung Disease. (2022/07/01) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Alpha-1 Antitrypsin Deficiency: Does Increased Neutrophil Adhesion Contribute to Lung Damage? (2022/07/01) ♡
• [Impact of COVID-19 pandemic on information management and adherence to replacement therapy with AAT of patients with alpha-1 antitrypsin deficiency (AATM)]. (2022/07/01) ♡
• Intravenous Alpha-1 Antitrypsin Therapy for Critically Ill COVID-19 Patients. (2022/07/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Vanishing lung syndrome masquerading as pneumothorax in a smoker: Now you see me, now you do not. (2022/07/01) ♡
• Low Prevalence of Mild Alpha-1-Antitrypsin Deficiency in Hospitalized COVID-19-Patients. (2022/06/28) ♡

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