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Systemic sclerosis (scleroderma)

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Search Period All yearsLast 12 monthsLast 5 years Topic All topicsGeneralNutrition and dietAlternative treatment methods Type of research Any type of researchHighest level of evidence only (64)Meta-analysis (20)Treatment guideline (3)Systematic review (23)Randomized trial (11)Phase 3 study (7)Clinical trial (611)Review article (416)Early study (phase 1 or 2) (31)Case report (178)Laboratory or animal study (26)Commentary or editorial (42)Retracted publication (2) Only studies currently recruiting participants (42)

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Publications (1501)

• [New directions of pharmacotherapy of immune - inflammatory rheumatic diseases]. (2019/08/15) ♡
• Systematic reviewiAll research on one question is searched according to fixed rules and compared side by side, so that no studies with poor outcomes are missed. Ocular involvement in systemic sclerosis: A systematic literature review, it's not all scleroderma that meets the eye. (2019/08/01) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Commentary on the article: Hughes M & Pauling JD. Exploring the patient experience of digital ulcers in systemic sclerosis. Semin Arthritis Rheum. 2018 Aug 11. pii: S0049-0172(18)30354-8. doi: 10.1016/j.semarthrit.2018.08.001. [Epub ahead of print] Review. (2019/08/01) ♡
• Systematic reviewiAll research on one question is searched according to fixed rules and compared side by side, so that no studies with poor outcomes are missed. The efficacy of dietary intervention on gastrointestinal involvement in systemic sclerosis: A systematic literature review. (2019/08/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Role and safety of fundoplication in esophageal disease and dysmotility syndromes. (2019/08/01) ♡
• Bufei Qingyu Granules Inhibit the Development of Systemic Sclerosis via Notch-1/Jagged-2 Signaling Pathway. (2019/07/02) ♡
• Association Between Exposure to Heavy Metals and Systemic Sclerosis: the Levels of Al, Cd, Hg, and Pb in Blood and Urine of Patients. (2019/07/01) ♡
• Vitamin D increases the production of IL-10 by regulatory T cells in patients with systemic sclerosis. (2019/07/01) ♡
• A Comparison Study of Efficacy and Safety of a Biosimilar Form of Intramuscular Βeta-interferon I-a Versus the Reference Product: A Randomized Controlled Clinical Trial in Iran. (2019/07/01) ♡
• Comparison of the clinical phenotype of systemic sclerosis patients in Iran and France in two university centers. (2019/06/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Systemic sclerosis and primary biliary cholangitis: An overlapping entity? (2019/06/01) ♡
• Clinical associations of serum leptin and leptin/adiponectin ratio in systemic sclerosis. (2019/06/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Immunological effects of vitamin D and their relations to autoimmunity. (2019/06/01) ♡
• Vitamin D serum levels and the risk of digital ulcers in systemic sclerosis: A longitudinal study. (2019/06/01) ♡
• [Sjögren's syndrome with juvenile onset]. (2019/05/15) ♡
• Nobiletin Protects against Systemic Inflammation-Stimulated Memory Impairment via MAPK and NF-κB Signaling Pathways. (2019/05/08) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Dietary Habits Bursting into the Complex Pathogenesis of Autoimmune Diseases: The Emerging Role of Salt from Experimental and Clinical Studies. (2019/05/05) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Esophageal symptoms and their lack of association with high-resolution manometry in systemic sclerosis patients. (2019/05/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Challenges in the diagnosis and treatment of disabling pansclerotic morphea of childhood: case-based review. (2019/05/01) ♡
• A gene-based recessive diplotype exome scan discovers FGF6, a novel hepcidin-regulating iron-metabolism gene. (2019/04/25) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Familial Mediterranean Fever and Multiple Sclerosis Successfully Treated With Interferon Beta-1a: A Case Report. (2019/04/22) ♡
• Association of Signal Transducer and Activator of Transcription 4 rs10181656 Polymorphism With Rheumatoid Arthritis and Systemic Sclerosis in Khuzestan Province in Southwestern Iran. (2019/04/06) ♡
• Reasons for attending support groups and organizational preferences: the European scleroderma support group members survey. (2019/04/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. An Autopsy Case with Cerebral Hemorrhaging due to disseminated Aspergillosis During Glucocorticoid Therapy for Overlap Syndrome of Systemic Lupus Erythematosus and Systemic Sclerosis. (2019/04/01) ♡
• Lysyl oxidase enzymes mediate TGF-β1-induced fibrotic phenotypes in human skin-like tissues. (2019/04/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. The role of metabolism in the pathogenesis of systemic sclerosis. (2019/04/01) ♡
• Safety of cladribine tablets in the treatment of patients with multiple sclerosis: An integrated analysis. (2019/04/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. [Calcinosis and scleroderma]. (2019/04/01) ♡
• Prevalence and associated factors of small intestinal bacterial overgrowth among systemic sclerosis patients. (2019/04/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Treatment of systemic sclerosis associated fibrotic manifestations: Current options and future directions. (2019/03/28) ♡
• Nailfold Videocapillaroscopy as a Candidate Biomarker for Organ Involvement and Prognosis in Patients with Systemic Sclerosis. (2019/03/28) ♡
• The Association of Inflammatory Bowel Diseases with Autoimmune Disorders: A Report from the epi-IIRN. (2019/03/26) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Lymphatic Function in Autoimmune Diseases. (2019/03/20) ♡
• Circulating AQP4-specific auto-antibodies alone can induce neuromyelitis optica spectrum disorder in the rat. (2019/03/01) ♡
• Meta-analysisiAll studies on one question combined and calculated together. This is the strongest form of research that exists: a single loose study can be coincidence, dozens together much less so. The label says something about the design, not about the outcome — which can also be that something does NOT work. Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases. (2019/03/01) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Identifying the Signature Immune Phenotypes Present in Pediatric Localized Scleroderma. (2019/03/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Multiple Sclerosis and Autoimmune Neurology of the Central Nervous System. (2019/03/01) ♡
• Insulin-like growth factor binding protein-4 exerts antifibrotic activity by reducing levels of connective tissue growth factor and the C-X-C chemokine receptor 4. (2019/03/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Emphysematous Gut. (2019/03/01) ♡
• Human health in relation to exposure to solar ultraviolet radiation under changing stratospheric ozone and climate. (2019/03/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Mandibular resorption and vocal cord paralysis: a catastrophic form of systemic sclerosis. (2019/02/28) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Idiopathic inflammatory myopathies: state of the art on clinical practice guidelines [corrected]. (2019/02/26) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Undifferentiated connective tissue disease: state of the art on clinical practice guidelines. (2019/02/26) ♡
• Nicousamide attenuates renal dysfunction and glomerular injury in remnant kidneys by inhibiting TGF-β1 internalisation and renin activity. (2019/02/15) ♡
• Exocrine pancreatic function is preserved in systemic sclerosis. (2019/02/12) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Nailfold avascular score and coronary microvascular dysfunction in systemic sclerosis: A newsworthy association. (2019/02/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Interleukin-13: A promising therapeutic target for autoimmune disease. (2019/02/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Erythema nodosum in a patient with multiple sclerosis on dimethyl fumarate. (2019/02/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Abatacept to treat chronic intestinal pseudo-obstruction in five systemic sclerosis patients with a description of the index case. (2019/02/01) ♡
• Are diffuse and limited juvenile systemic sclerosis different in clinical presentation? Clinical characteristics of a juvenile systemic sclerosis cohort. (2019/02/01) ♡

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