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Systemic sclerosis (scleroderma)

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Search Period All yearsLast 12 monthsLast 5 years Topic All topicsGeneralNutrition and dietAlternative treatment methods Type of research Any type of researchStrongest evidence only (63)Meta-analysis (20)Treatment guideline (3)Systematic review (23)Randomized trial (11)Phase 3 study (6)Clinical trial (613)Review article (416)Early study (phase 1 or 2) (29)Case report (178)Laboratory or animal study (26)Commentary or editorial (42)Retracted publication (2) Studies currently recruiting participants only (39)

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Publications and studies (2101)

• The impact of ambrisentan and tadalafil upfront combination therapy on cardiac function in scleroderma associated pulmonary arterial hypertension patients: cardiac magnetic resonance feature tracking study. (2018/01/01) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Systemic sclerosis: Annual chest CT is not necessary for all patients. (2018/01/01) ♡
• Tuberous sclerosis presenting as neonatal cyanosis because of rhabdomyoma causing tricuspid valve obstruction needing a Blalock-Taussig shunt. (2018/01/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Mycophenolate mofetil as a therapeutic agent for interstitial lung diseases in systemic sclerosis. (2018/01/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Pulmonary arterial hypertension in the setting of scleroderma is different than in the setting of lupus: A review. (2018/01/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Respiratory effects of trichloroethylene. (2018/01/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Progranulin: A key player in autoimmune diseases. (2018/01/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Breastfeeding and autoimmunity: Programing health from the beginning. (2018/01/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Anti-inflammatory Activity of Extra Virgin Olive Oil Polyphenols: Which Role in the Prevention and Treatment of Immune-Mediated Inflammatory Diseases? (2018/01/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Microbiome, Immunomodulation, and the Neuronal System. (2018/01/01) ♡
• Gastrointestinal Manifestations of Systemic Sclerosis. (2018/01/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Cell Membrane-Derived Microvesicles in Systemic Inflammatory Response. (2018/01/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Dkk1: A key molecule in joint remodelling and fibrosis. (2017/12/22) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Disease evolution in mixed connective tissue disease: results from a long-term nationwide prospective cohort study. (2017/12/21) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Microvascular damage evaluation in systemic sclerosis: the role of nailfold videocapillaroscopy and laser techniques. (2017/12/21) ♡
• The role of klotho in systemic sclerosis. (2017/12/21) ♡
• Evolution, trends, outcomes, and economics of hematopoietic stem cell transplantation in severe autoimmune diseases. (2017/12/20) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. The validity and reliability of using ultrasound elastography to measure cutaneous stiffness, a systematic review. (2017/12/20) ♡
• The non-neuronal cyclin-dependent kinase 5 is a fibrotic mediator potentially implicated in systemic sclerosis and a novel therapeutic target. (2017/12/20) ♡
• A comparison of health-related quality of life (HRQoL) across four systemic autoimmune rheumatic diseases (SARDs). (2017/12/19) ♡
• Plasma urotensin II levels in primary Raynaud's phenomenon and systemic sclerosis. (2017/12/19) ♡
• Familial multiple sclerosis and association with other autoimmune diseases. (2017/12/19) ♡
• Histamine Receptor 3 negatively regulates oligodendrocyte differentiation and remyelination. (2017/12/18) ♡
• Factors associated with the 6-minute walk distance in patients with systemic sclerosis. (2017/12/15) ♡
• Extracellular miR-145, miR-223 and miR-326 expression signature allow for differential diagnosis of immune-mediated neuroinflammatory diseases. (2017/12/15) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Recent advances in understanding NRF2 as a druggable target: development of pro-electrophilic and non-covalent NRF2 activators to overcome systemic side effects of electrophilic drugs like dimethyl fumarate. (2017/12/14) ♡
• Meta-analysisiAll studies on one question combined and calculated together. This is the strongest form of research that exists: a single loose study can be coincidence, dozens together much less so. The label says something about the design, not about the outcome — which can also be that something does NOT work. Calcium channel blockers for primary and secondary Raynaud's phenomenon. (2017/12/13) ♡
• Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis. (2017/12/13) ♡
• Regulation of Fn14 Receptor and NF-κB Underlies Inflammation in Meniere's Disease. (2017/12/13) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Retrocochlear impairments in systemic sclerosis: a case report study. (2017/12/07) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Vitamin D deficiency in systemic sclerosis: a possible role of subclinical liver fibrosis? Retrospective analysis from an Italian cohort. (2017/12/01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Quantifying the direct public health care cost of systemic sclerosis: A comprehensive data linkage study. (2017/12/01) ♡
• Association Study of CD226 and CD247 Genes Single Nucleotide Polymorphisms in Iranian Patients with Systemic Sclerosis. (2017/12/01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Clinical and serological features of systemic sclerosis in a multicenter African American cohort: Analysis of the genome research in African American scleroderma patients clinical database. (2017/12/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Revisiting the gamma loop in ALS. (2017/12/01) ♡
• Circulating angiostatin serum level in patients with systemic sclerosis. (2017/12/01) ♡
• Hoarseness in Adults. (2017/12/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Atrophic and Annular Scarring Alopecia of the Scalp as a Finding in Underlying Systemic Sarcoidosis. (2017/12/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Cutaneous metastasis to the scalp as the primary presentation of colorectal adenocarcinoma. (2017/11/15) ♡
• Early-stage study (phase 1 or 2)iEarly research in a small group, primarily aimed at safety and dosage. Whether it actually works still needs to be determined afterward. Novel lung imaging biomarkers and skin gene expression subsetting in dasatinib treatment of systemic sclerosis-associated interstitial lung disease. (2017/11/09) ♡
• Early-Life Antibiotic Exposure Causes Intestinal Dysbiosis and Exacerbates Skin and Lung Pathology in Experimental Systemic Sclerosis. (2017/11/01) ♡
• Serum osteopontin and vitronectin levels in systemic sclerosis. (2017/11/01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Prevalence of thyroid autoantibodies in patients with systematic autoimmune rheumatic diseases. Cross-sectional study. (2017/11/01) ♡
• Scleroderma in hospital settings in Lomé: 50 cases. (2017/11/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Importance of alternative-site blood glucose testing in the diagnosis of artifactual hypoglycaemia in systemic scleroderma. (2017/10/01) ♡
• Altered diurnal cardiac sympathovagal balance correlates with nutritional status indexes in systemic sclerosis patients. (2017/10/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. ANCA-Positive pauci-immune crescentic glomerulonephritis in a patient with systemic lupus erythematosus. (2017/10/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Diagnostic potential of tears in ophthalmology. (2017/10/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Lupus and scleroderma overlap features in a 28-year-old man with anti-PL-12 anti-synthetase syndrome. (2017/09/15) ♡
• Impact of combined sodium chloride and saturated long-chain fatty acid challenge on the differentiation of T helper cells in neuroinflammation. (2017/09/12) ♡

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