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Sickle cell disease

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Search Period All yearsLast 12 monthsLast 5 years Topic All topicsGeneralNutrition and dietAlternative treatment methods Type of research Any type of researchHighest quality evidence only (79)Meta-analysis (14)Treatment guideline (2)Randomized trial (30)Systematic review (27)Phase 3 study (6)Clinical trial (629)Review article (209)Early study (phase 1 or 2) (16)Case report (141)Laboratory or animal research (19)Commentary or editorial (54)Retracted publication (2) Studies currently recruiting participants only (34)

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Publications and studies (2107)

• Phase 3 studyiResearch in a large group of patients, the final step before a treatment can be approved. What comes out here carries significant weight. Transfusion management of severe anaemia in African children: a consensus algorithm. (2021/06/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Sleep Deficiency and Pediatric Chronic Pain. (2021/06/01) ♡
• Relationship between disease severity and folate status of children with sickle cell anaemia in Enugu, South East Nigeria. (2021/06/01) ♡
• Nutritional and Hematological Status of Sudanese Women of Childbearing Age with Steady-state Sickle Cell Anemia. (2021/05/31) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Dietary ω-3 Fatty Acid Supplementation Improves Murine Sickle Cell Bone Disease and Reprograms Adipogenesis. (2021/05/18) ♡
• FT-4202, an oral PKR activator, has potent antisickling effects and improves RBC survival and Hb levels in SCA mice. (2021/05/11) ♡
• Mechanisms of pain in sickle cell disease. (2021/05/01) ♡
• Impact of COVID-19 on vasooclusive crisis in patients with sickle cell anaemia. (2021/05/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Distal Renal Tubular Acidosis due to Primary Sjögren's Syndrome: Presents as Hypoakalemic Paralysis with Hypokalemia-Induced Nephrogenic Diabetes Insipidus. (2021/05/01) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Sickle cell anaemia & glucose-6-phosphate dehydrogenase (G6PD) deficiency in Lahaul & Spiti, a tribal district of Himachal Pradesh. (2021/05/01) ♡
• Detectable Unmetabolized Folic Acid and Elevated Folate Concentrations in Folic Acid-Supplemented Canadian Children With Sickle Cell Disease. (2021/04/21) ♡
• A 90-Day Oral Toxicity of Hydroethanolic Root Extract of Carissa spinarum in Wistar Rats. (2021/04/20) ♡
• Association of Blood Pressure Genetic Risk Score with Cardiovascular Disease and CKD Progression: Findings from the CRIC Study. (2021/04/08) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Sickle Cell Trait Presenting as Chronic Calcific Pancreatitis with Pseudocyst- A Case Report. (2021/04/01) ♡
• Polymorphisms in the heme oxygenase-1 and bone morphogenetic protein receptor type 1b genes and estimated glomerular filtration rate in Brazilian sickle cell anemia patients. (2021/04/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Things must not fall apart: the ripple effects of the COVID-19 pandemic on children in sub-Saharan Africa. (2021/04/01) ♡
• TSPO ligand FGIN-1-27 controls priapism in sickle cell mice via endogenous testosterone production. (2021/04/01) ♡
• Hydroxyurea Pharmacokinetics in Pediatric Patients After Total Pancreatectomy With Islet Autotransplantation. (2021/04/01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Weight status and health behaviors of adolescents and young adults with sickle cell disease: The emerging risk for obesity. (2021/04/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Clinical management of sickle cell liver disease in children and young adults. (2021/04/01) ♡
• Malaria is a cause of iron deficiency in African children. (2021/04/01) ♡
• Methylenetetrahydrofolate reductase polymorphisms as genetic markers to predict homocysteinemia and clinical severity in sickle cell disease. (2021/04/01) ♡
• Discovery and fine-mapping of height loci via high-density imputation of GWASS in individuals of African ancestry. (2021/04/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Epidemiology, Pathogenesis, and Clinical Approach in Group 5 Pulmonary Hypertension. (2021/03/25) ♡
• Red blood cell mannoses as phagocytic ligands mediating both sickle cell anaemia and malaria resistance. (2021/03/19) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Dietary iron restriction improves markers of disease severity in murine sickle cell anemia. (2021/03/18) ♡
• Nutritional perspectives on sickle cell disease in Africa: a systematic review. (2021/03/18) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Microfluidics in Sickle Cell Disease Research: State of the Art and a Perspective Beyond the Flow Problem. (2021/03/08) ♡
• Mortality in sickle cell disease: A population-based study in an aboriginal community in the Gudalur Valley, Nilgiris, Tamil Nadu, India. (2021/03/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Transfusion and Cellular Therapy in Pediatric Sickle Cell Disease. (2021/03/01) ♡
• Emotion regulation, pain interference and affective symptoms in children and adolescents with sickle cell disease. (2021/03/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Pica in Pediatric Sickle Cell Disease. (2021/03/01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Epidemiology of community-acquired acute kidney injury in children as seen in an emergency room of Tertiary Hospital in South-South Nigeria. (2021/03/01) ♡
• Systematic reviewiAll research on one question is searched according to fixed rules and compared side by side, so that no studies with poor outcomes are missed. Evidence-based interventions implemented in low and middle-income countries for sickle cell disease management: A systematic review of randomized controlled trials. (2021/02/17) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Implementation science research for the scale-up of evidence-based interventions for sickle cell disease in Africa: a commentary. (2021/02/17) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Mechanisms of Bone Impairment in Sickle Bone Disease. (2021/02/13) ♡
• Inflammatory Dendritic Cells Contribute to Regulate the Immune Response in Sickle Cell Disease. (2021/02/04) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. A Small Key for a Heavy Door: Genetic Therapies for the Treatment of Hemoglobinopathies. (2021/02/04) ♡
• Anxiety level and clinical course of patients with sickle cell disease during the COVID-19 outbreak. (2021/02/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Nitric oxide and sickle cell Disease-is there a painful connection? (2021/02/01) ♡
• Meta-analysisiAll studies on one question combined and calculated together. This is the strongest form of research that exists: a single loose study can be coincidence, dozens together much less so. The label says something about the design, not about the outcome — which can also be that something does NOT work. Systematic Review/Meta-Analysis on Efficacy of Allogeneic Hematopoietic Cell Transplantation in Sickle Cell Disease: An International Effort on BeHALF of the Pediatric Diseases Working Party of European Society for Blood and Marrow Transplantation and the Sickle Cell Transplantation International Consortium. (2021/02/01) ♡
• Acute Liver Failure in a Sickle Cell Patient. (2021/02/01) ♡
• Diet and companionship modulate pain via a serotonergic mechanism. (2021/02/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. The Worst Things in Life are Free: The Role of Free Heme in Sickle Cell Disease. (2021/01/27) ♡
• Reactive Oxygen Species-Triggered Dissociation of a Polyrotaxane-Based Nanochelator for Enhanced Clearance of Systemic and Hepatic Iron. (2021/01/26) ♡
• Neutrophil-Derived Myeloperoxidase Facilitates Both the Induction and Elicitation Phases of Contact Hypersensitivity. (2021/01/25) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. In utero Therapy for the Treatment of Sickle Cell Disease: Taking Advantage of the Fetal Immune System. (2021/01/22) ♡
• Endothelial TLR4 Expression Mediates Vaso-Occlusive Crisis in Sickle Cell Disease. (2021/01/19) ♡
• Consequences of β-Thalassemia or Sickle Cell Disease for Ovarian Follicle Number and Morphology in Girls Who Had Ovarian Tissue Cryopreserved. (2021/01/15) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Undernutrition: a major but potentially preventable cause of poor outcomes in children living with sickle cell disease in Africa. (2021/01/15) ♡

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