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Primary lateral sclerosis

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Search Period All yearsLast 12 monthsLast 5 years Topic All topicsGeneralNutrition and dietAlternative treatment methods Type of research Any type of researchHighest evidence only (123)Meta-analysis (29)Treatment guideline (6)Systematic review (51)Randomized controlled trial (19)Phase 3 study (18)Clinical trial (658)Review article (336)Early-stage study (phase 1 or 2) (13)Laboratory or animal research (123)Case description (120)Commentary or editorial (46)Retracted publication (1) Studies currently recruiting participants only (31)

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Publications and studies (2508)

• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Farrell valve relieves bloating in gastrostomy patient. (2017/09/01) ♡
• Cognitive and motor performance in Congolese children with konzo during 4 years of follow-up: a longitudinal analysis. (2017/09/01) ♡
• Exposure to BMAA mirrors molecular processes linked to neurodegenerative disease. (2017/09/01) ♡
• Inhibitory Basal Ganglia Inputs Induce Excitatory Motor Signals in the Thalamus. (2017/08/30) ♡
• Pesticide exposure assessed through agricultural crop proximity and risk of amyotrophic lateral sclerosis. (2017/08/29) ♡
• Electroacupuncture Promotes Recovery of Motor Function and Reduces Dopaminergic Neuron Degeneration in Rodent Models of Parkinson's Disease. (2017/08/24) ♡
• Alterations in neuronal control of body weight and anxiety behavior by glutathione peroxidase 4 deficiency. (2017/08/15) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Zinc containing dental fixative causing copper deficiency myelopathy. (2017/08/08) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Diets for Patients with Amyotrophic Lateral Sclerosis: Pay Attention to Nutritional Intervention. (2017/08/05) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. [Causes of death in amyotrophic lateral sclerosis: Results from the Rhineland-Palatinate ALS registry]. (2017/08/01) ♡
• Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration. (2017/08/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. SMA mutations in SMN Tudor and C-terminal domains destabilize the protein. (2017/08/01) ♡
• The evaluation of bulbar dysfunction in amyotrophic lateral sclerosis: survey of clinical practice patterns in the United States. (2017/08/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. [Calcium ion is a common denominator in the pathophysiological processes of amyotrophic lateral sclerosis]. (2017/07/30) ♡
• Meta-analysisiAll studies on one question combined and calculated together. This is the strongest form of research that exists: a single loose study can be coincidence, dozens together much less so. The label says something about the design, not about the outcome — which can also be that something does NOT work. Identification of risk factors associated with onset and progression of amyotrophic lateral sclerosis using systematic review and meta-analysis. (2017/07/01) ♡
• Pigment retinopathy in warmblood horses with equine degenerative myeloencephalopathy and equine motor neuron disease. (2017/07/01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Gastrostomies Preserve But Do Not Increase Quality of Life for Patients and Caregivers. (2017/07/01) ♡
• Enteral feeding in motor neurone disease: Patients' perspectives and impact on quality of life. (2017/07/01) ♡
• The challenges of dysphagia in treating motor neurone disease. (2017/07/01) ♡
• Essay On Being A Doctor: Mirrors. (2017/07/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Alternative Fuels in Epilepsy and Amyotrophic Lateral Sclerosis. (2017/06/01) ♡
• Blood trace metals in a sporadic amyotrophic lateral sclerosis geographical cluster. (2017/06/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. [Possible treatments for infantile spinal atrophy]. (2017/05/17) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. An analysis of prognostic factors after percutaneous endoscopic gastrostomy placement in Japanese patients with amyotrophic lateral sclerosis. (2017/05/15) ♡
• PEG Insertion in Patients With Dementia Does Not Improve Nutritional Status and Has Worse Outcomes as Compared With PEG Insertion for Other Indications. (2017/05/01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Percutaneous endoscopic gastrostomy, body weight loss and survival in amyotrophic lateral sclerosis: a population-based registry study. (2017/05/01) ♡
• A risk stratifying tool to facilitate safe late-stage percutaneous endoscopic gastrostomy in ALS. (2017/05/01) ♡
• Incidence of amyotrophic lateral sclerosis in the province of Novara, Italy, and possible role of environmental pollution. (2017/05/01) ♡
• Pesticides, polychlorinated biphenyls and polycyclic aromatic hydrocarbons in cerebrospinal fluid of amyotrophic lateral sclerosis patients: a case-control study. (2017/05/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Motor neurone disease: progress and challenges. (2017/05/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Care management in amyotrophic lateral sclerosis. (2017/05/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Clinical features of amyotrophic lateral sclerosis and their prognostic value. (2017/05/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Ethical considerations and palliative care in patients with amyotrophic lateral sclerosis: A review. (2017/05/01) ♡
• Meta-analysisiAll studies on one question combined and calculated together. This is the strongest form of research that exists: a single loose study can be coincidence, dozens together much less so. The label says something about the design, not about the outcome — which can also be that something does NOT work. WITHDRAWN: Interventions for fatigue and weight loss in adults with advanced progressive illness. (2017/04/07) ♡
• Genome-wide RNA-seq of iPSC-derived motor neurons indicates selective cytoskeletal perturbation in Brown-Vialetto disease that is partially rescued by riboflavin. (2017/04/06) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Withania somnifera Reverses Transactive Response DNA Binding Protein 43 Proteinopathy in a Mouse Model of Amyotrophic Lateral Sclerosis/Frontotemporal Lobar Degeneration. (2017/04/01) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Neuroprotective effect of breviscapine on traumatic brain injury in rats associated with the inhibition of GSK3β signaling pathway. (2017/04/01) ♡
• Experience matters: neurologists' perspectives on ALS patients' well-being. (2017/04/01) ♡
• No association between gluten sensitivity and amyotrophic lateral sclerosis. (2017/04/01) ♡
• Low bone mineral density and fractures are highly prevalent in pediatric patients with spinal muscular atrophy regardless of disease severity. (2017/04/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Pseudo-Atrial Flutter Secondary to a Chest Wall Percussion Device. (2017/04/01) ♡
• Increased mitophagy in the skeletal muscle of spinal and bulbar muscular atrophy patients. (2017/03/15) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Sensory Neuronopathy Revealing Severe Vitamin B12 Deficiency in a Patient with Anorexia Nervosa: An Often-Forgotten Reversible Cause. (2017/03/15) ♡
• Humulus japonicus Prevents Dopaminergic Neuron Death in 6-Hydroxydopamine-Induced Models of Parkinson's Disease. (2017/02/01) ♡
• Phase 3 studyiResearch in a large group of patients, the final step before a treatment can be approved. What comes out here carries significant weight. Serum urate at trial entry and ALS progression in EMPOWER. (2017/02/01) ♡
• Spinal Muscular Atrophy Type I: Is It Ethical to Standardize Supportive Care Intervention in Clinical Trials? (2017/02/01) ♡
• A Novel Iron Chelator-Radical Scavenger Ameliorates Motor Dysfunction and Improves Life Span and Mitochondrial Biogenesis in SOD1(G93A) ALS Mice. (2017/02/01) ♡
• The measurement and estimation of total energy expenditure in Japanese patients with ALS: a doubly labelled water method study. (2017/02/01) ♡
• Systematic reviewiAll research on one question is searched according to fixed rules and compared side by side, so that no studies with poor outcomes are missed. Symptomatic treatments for amyotrophic lateral sclerosis/motor neuron disease. (2017/01/10) ♡
• Association between estimated total daily energy expenditure and stage of amyotrophic lateral sclerosis. (2017/01/01) ♡

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