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Primary lateral sclerosis

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Search Period All yearsLast 12 monthsLast 5 years Topic All topicsGeneralNutrition and dietAlternative treatment methods Type of research Any type of researchHighest evidence only (123)Meta-analysis (29)Treatment guideline (6)Systematic review (51)Randomized controlled trial (19)Phase 3 study (18)Clinical trial (658)Review article (336)Early-stage study (phase 1 or 2) (13)Laboratory or animal research (123)Case description (120)Commentary or editorial (46)Retracted publication (1) Studies currently recruiting participants only (31)

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Publications and studies (2508)

• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Immune Signaling Kinases in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). (2021/12/10) ♡
• Systematic reviewiAll research on one question is searched according to fixed rules and compared side by side, so that no studies with poor outcomes are missed. Wearable GPS and Accelerometer Technologies for Monitoring Mobility and Physical Activity in Neurodegenerative Disorders: A Systematic Review. (2021/12/10) ♡
• Sequestosome 1 Is Part of the Interaction Network of VAPB. (2021/12/09) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Characterization of Neuromuscular Junctions in Mice by Combined Confocal and Super-Resolution Microscopy. (2021/12/08) ♡
• MOBP rs616147 Polymorphism and Risk of Amyotrophic Lateral Sclerosis in a Greek Population: A Case-Control Study. (2021/12/07) ♡
• Tat-p27 Ameliorates Neuronal Damage Reducing α-Synuclein and Inflammatory Responses in Motor Neurons After Spinal Cord Ischemia. (2021/12/01) ♡
• The nutritional management of people living with amyotrophic lateral sclerosis: A national survey of dietitians. (2021/12/01) ♡
• Prolonged fasting-induced hyperketosis, hypoglycaemia and impaired fat oxidation in child and adult patients with spinal muscular atrophy type II. (2021/12/01) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. YAC128 mouse model of Huntington disease is protected against subtle chronic manganese (Mn)-induced behavioral and neuropathological changes. (2021/12/01) ♡
• Stress load and neurodegeneration after gastrostomy tube placement in amyotrophic lateral sclerosis patients. (2021/12/01) ♡
• Blenderized Tube Feeding and Enterostomy Tube Occlusions Among Adults with Amyotrophic Lateral Sclerosis and Primary Lateral Sclerosis. (2021/12/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. [Amyotrophic lateral sclerosis (ALS) - diagnosis, course of disease and treatment options]. (2021/12/01) ♡
• Effect of the type of specialized nutrition support on the course of the patient with amyotrophic lateral sclerosis (ALS). Interhospital registry SCLEDyN. (2021/12/01) ♡
• Systematic reviewiAll research on one question is searched according to fixed rules and compared side by side, so that no studies with poor outcomes are missed. The Safety and Efficacy of Stem Cell Therapy as an Emerging Therapy for ALS: A Systematic Review of Controlled Clinical Trials. (2021/12/01) ♡
• The BCH message banking process™, voice banking, and double-dipping™. (2021/12/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Familial amyotrophic lateral sclerosis induced by gene mutation of SOD1G142A: a case report. (2021/12/01) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Distal Acquired Demyelinating Symmetric Neuropathy Associated with Decreased Electrical Excitability of the Femoral Nerves. (2021/12/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. [Fasciculations and cramps: physiological bases and clinical approach of a complex phenomenon]. (2021/12/01) ♡
• Discussing Personalized Prognosis Empowers Patients with Amyotrophic Lateral Sclerosis to Regain Control over Their Future: A Qualitative Study. (2021/11/30) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Juvenile Amyotrophic Lateral Sclerosis: A Review. (2021/11/30) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Phenoconversion from Spastic Paraplegia to ALS/FTD Associated with CYP7B1 Compound Heterozygous Mutations. (2021/11/25) ♡
• Identification of FOXG1 mutations in infantile hypotonia and postnatal microcephaly. (2021/11/24) ♡
• Individual Oligogenic Background in p.D91A-SOD1 Amyotrophic Lateral Sclerosis Patients. (2021/11/23) ♡
• Teaching an old dog new tricks: serum troponin T as a biomarker in amyotrophic lateral sclerosis. (2021/11/17) ♡
• Anti-inflammatory Effects of a Novel Herbal Extract in the Muscle and Spinal Cord of an Amyotrophic Lateral Sclerosis Animal Model. (2021/11/11) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. An Unusual Cause of Bulbar Palsy in the Emergency Department. (2021/11/01) ♡
• The Influence of Striatal Astrocyte Dysfunction on Locomotor Activity in Dopamine-depleted Rats. (2021/11/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Nutrient Effects on Motor Neurons and the Risk of Amyotrophic Lateral Sclerosis. (2021/10/26) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Intrathecal Administration of Nusinersen Using the Ommaya Reservoir in an Adult with 5q-Related Spinal Muscular Atrophy Type 1 and Severe Spinal Deformity. (2021/10/26) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Case Report: Stem cell therapy in amyotrophic lateral sclerosis. (2021/10/25) ♡
• Body Fat Percentage and Availability of Oral Food Intake: Prognostic Factors and Implications for Nutrition in Amyotrophic Lateral Sclerosis. (2021/10/21) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. High-fat diet-associated cognitive decline: Is zinc finger protein 1 (ZPR1) the molecular connection? (2021/10/02) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Peripheral neuropathy in ALS: phenotype association. (2021/10/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Expert recommendations and clinical considerations in the use of onasemnogene abeparvovec gene therapy for spinal muscular atrophy. (2021/10/01) ♡
• Lytico-bodig in Guam: Historical links between diet and illness during and after Spanish colonization. (2021/10/01) ♡
• Systematic reviewiAll research on one question is searched according to fixed rules and compared side by side, so that no studies with poor outcomes are missed. Matching-adjusted indirect treatment comparison of onasemnogene abeparvovec and nusinersen for the treatment of symptomatic patients with spinal muscular atrophy type 1. (2021/10/01) ♡
• Association of Variants in the SPTLC1 Gene With Juvenile Amyotrophic Lateral Sclerosis. (2021/10/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Progressive muscle weakness and amyotrophy during pregnancy as the first manifestation of systemic lupus erythematosus: A case report and review of literature. (2021/10/01) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Diosgenin Prevents Microglial Activation and Protects Dopaminergic Neurons from Lipopolysaccharide-Induced Neural Damage In Vitro and In Vivo. (2021/09/26) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Peiminine Reduces ARTS-Mediated Degradation of XIAP by Modulating the PINK1/Parkin Pathway to Ameliorate 6-Hydroxydopamine Toxicity and α-Synuclein Accumulation in Parkinson's Disease Models In Vivo and In Vitro. (2021/09/23) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. The gut microbiome in konzo. (2021/09/10) ♡
• Prognostic prediction by hypermetabolism varies depending on the nutritional status in early amyotrophic lateral sclerosis. (2021/09/09) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Growth patterns in children with spinal muscular atrophy. (2021/09/04) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. When paediatric facial nerve paralysis is not a Bell's palsy: A case of cerebellopontine angle tumour. (2021/09/04) ♡
• Real-world respiratory and bulbar comorbidities of SMA type 1 children treated with nusinersen: 2-Year single centre Australian experience. (2021/09/01) ♡
• Analysis of the diagnostic pathway and delay in patients with amyotrophic lateral sclerosis in the Valencian Community. (2021/09/01) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Riluzole does not ameliorate disease caused by cytoplasmic TDP-43 in a mouse model of amyotrophic lateral sclerosis. (2021/09/01) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Three month inhalation exposure to low-level PM2.5 induced brain toxicity in an Alzheimer's disease mouse model. (2021/08/26) ♡
• Genetically Predicted Milk Intake and Risk of Neurodegenerative Diseases. (2021/08/23) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Impact of Percutaneous Endoscopic Gastrostomy (PEG) on the Evolution of Disease in Patients with Amyotrophic Lateral Sclerosis (ALS). (2021/08/12) ♡

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