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Primary lateral sclerosis
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Publications and studies (2510)
- Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Qilong Capsule Alleviated MPTP-Induced Neuronal Defects by Inhibiting Apoptosis, Regulating Autophagy in Zebrafish Embryo Model. (2023/03/01) ♡
- Flexible endoscopic evaluation of swallowing in children with type 1 spinal muscular atrophy. (2023/03/01) ♡
- Ultrasonographic and manometric study of the tongue as biomarkers of dysphagia in patients with amyotrophic lateral sclerosis. (2023/03/01) ♡
- Pathological Sequelae Associated with Skeletal Muscle Atrophy and Histopathology in G93A*SOD1 Mice. (2023/03/01) ♡
- Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Treatment of spinal muscular atrophy with Onasemnogene Abeparvovec in Switzerland: a prospective observational case series study. (2023/02/28) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. A comprehensive overview of SMN and NAIP copy numbers in Iranian SMA patients. (2023/02/24) ♡
- Commentary or editorialiAn expert's opinion or commentary, not new research. Decreasing mutant ATXN1 nuclear localization improves a spectrum of SCA1-like phenotypes and brain region transcriptomic profiles. (2023/02/15) ♡
- Self-reported factors contributing to delay in ALS diagnosis among primary care providers in a large Ohio-based US healthcare network. (2023/02/15) ♡
- Neurological soft signs are associated with reduced medial-lateral postural control in adolescent athletes. (2023/02/15) ♡
- Commentary or editorialiAn expert's opinion or commentary, not new research. Neuroprotection by Drugs, Nutraceuticals and Physical Activity. (2023/02/06) ♡
- Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Ultrasound-guided glenohumeral joint injections for shoulder pain in ALS: A case series. (2023/02/02) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. ALSUntangled #63: ketogenic diets. (2023/02/01) ♡
- Occupational lead exposure and survival with amyotrophic lateral sclerosis. (2023/02/01) ♡
- A geographical study on amyotrophic lateral sclerosis in Rio Grande Do Norte, Brazil, from 2005 to 2018. (2023/02/01) ♡
- Voiceprint and machine learning models for early detection of bulbar dysfunction in ALS. (2023/02/01) ♡
- Axial postural abnormalities and pain in Parkinson's disease. (2023/02/01) ♡
- Protective effect of human umbilical cord mesenchymal stem cell derived conditioned medium in a mutant TDP-43 induced motoneuron-like cellular model of ALS. (2023/02/01) ♡
- Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Neutralizing peripheral circulating IL1β slows the progression of ALS in a lentivirus-infected OPTN(E478G) mouse model. (2023/02/01) ♡
- Oxidative stress disrupts the cytoskeleton of spinal motor neurons. (2023/02/01) ♡
- A liquid-to-solid phase transition of Cu/Zn superoxide dismutase 1 initiated by oxidation and disease mutation. (2023/02/01) ♡
- Inherited myopathy plus: Double-trouble from rare neuromuscular disorders. (2023/02/01) ♡
- Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of amyotrophic lateral sclerosis. (2023/02/01) ♡
- Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Factors predicting disease progression in C9ORF72 ALS patients. (2023/02/01) ♡
- Risk factors for recurrent respiratory tract infections and acute respiratory failure in children with spinal muscular atrophy. (2023/02/01) ♡
- Identification of potential pathways and biomarkers linked to progression in ALS. (2023/02/01) ♡
- L-Theanine alleviates MPTP-induced Parkinson's disease by targeting Wnt/β-catenin signaling mediated by the MAPK signaling pathway. (2023/01/31) ♡
- Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Inorganic arsenic alters the development of dopaminergic neurons but not serotonergic neurons and induces motor neuron development via Sonic hedgehog pathway in zebrafish. (2023/01/31) ♡
- Assessment of motor function and nutritional status in children with spinal muscular atrophy treated with nusinersen after loading period in Western China: a retrospective study. (2023/01/23) ♡
- Neuronopathic GBA1L444P Mutation Accelerates Glucosylsphingosine Levels and Formation of Hippocampal Alpha-Synuclein Inclusions. (2023/01/18) ♡
- Trends in the diagnostic delay and pathway for amyotrophic lateral sclerosis patients across different countries. (2023/01/17) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Natural Bioactive Molecules as Neuromedicines for the Treatment/Prevention of Neurodegenerative Diseases. (2023/01/17) ♡
- Diagnostic utility of susceptibility-weighted imaging in amyotrophic lateral sclerosis. (2023/01/15) ♡
- Deep Intronic FGF14 GAA Repeat Expansion in Late-Onset Cerebellar Ataxia. (2023/01/12) ♡
- Systematic reviewiAll research on one question is searched according to fixed rules and compared side by side, so that no studies with poor outcomes are missed. Efficacy and safety of probiotics in Parkinson's constipation: A systematic review and meta-analysis. (2023/01/10) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. GRIN2B-related neurodevelopmental disorder: current understanding of pathophysiological mechanisms. (2023/01/10) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Split phenomena in amyotrophic lateral sclerosis: Current evidences, pathogenetic hypotheses and diagnostic implications. (2023/01/09) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Progress and challenges in directing the differentiation of human iPSCs into spinal motor neurons. (2023/01/05) ♡
- Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Case report: Motor neuron disease phenotype associated with symptomatic copper deficiency: Challenging diagnosis and treatment. (2023/01/04) ♡
- Comprehensive expression analysis with cell-type-specific transcriptome in ALS-linked mutant SOD1 mice: Revisiting the active role of glial cells in disease. (2023/01/04) ♡
- Chlorogenic acid delays the progression of Parkinson's disease via autophagy induction in Caenorhabditis elegans. (2023/01/01) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Current treatments of spinal muscular atrophy in adults. (2023/01/01) ♡
- Behavioral problems in infants and young children with spinal muscular atrophy and their siblings: A cross-sectional study. (2023/01/01) ♡
- Multidisciplinary clinic contributes to the decreasing trend in the number of emergency hospitalizations for amyotrophic lateral sclerosis in Japan. (2023/01/01) ♡
- Reduced-penetrance Huntington's disease-causing alleles with 39 CAG trinucleotide repeats could be a genetic factor of amyotrophic lateral sclerosis. (2023/01/01) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. The Natural Neuroprotective Compounds Used in the 6-Hydroxydopamine-Induced Parkinson's Disease in Zebrafish: The Current Applications and Perspectives. (2023/01/01) ♡
- GPX4 deficiency-dependent phospholipid peroxidation drives motor deficits of ALS. (2023/01/01) ♡
- Network Pharmacology and Molecular Docking to Unveil the Mechanism of Shudihuang against Amyotrophic Lateral Sclerosis. (2023/01/01) ♡
- 3,4-Dimethoxychalcone, a caloric restriction mimetic, enhances TFEB-mediated autophagy and alleviates pyroptosis and necroptosis after spinal cord injury. (2023/01/01) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. A review article on neuroprotective, immunomodulatory, and anti-inflammatory role of vitamin-D3 in elderly COVID-19 patients. (2023/01/01) ♡
- Patients with Spinal Muscular Atrophy Type 1 Achieve and Maintain Bulbar Function Following Onasemnogene Abeparvovec Treatment. (2023/01/01) ♡
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