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Primary lateral sclerosis
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Publications and studies (2510)
- Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Study of ALS Reversals 2: Genetic Analyses (2024-01-11) ♡
- Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Neurofilament Light Chain in Amyotrophic Lateral Sclerosis (2024-01-11) ♡
- Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Study of Structural and Functional Brain Connectivity Changes in ALS (CoALS-II) (2024-01-09) ♡
- Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. HERV-K Suppression Using Antiretroviral Therapy in Volunteers With Amyotrophic Lateral Sclerosis (ALS) (2024-01-09) ♡
- Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Clinical Trial - Analyzing Participation Experiences Of Amyotrophic Lateral Sclerosis Patients (2024-01-02) ♡
- Unveiling promising inhibitors of superoxide dismutase 1 (SOD1) for therapeutic interventions. (2023/12/31) ♡
- Peripheral Neuropathy and Decreased Locomotion of a RAB40B Mutation in Human and Model Animals. (2023/12/31) ♡
- Systematic reviewiAll research on one question is searched according to fixed rules and compared side by side, so that no studies with poor outcomes are missed. A Machine Learning Approach for Highlighting microRNAs as Biomarkers Linked to Amyotrophic Lateral Sclerosis Diagnosis and Progression. (2023/12/29) ♡
- Parvalbumin interneurons dysfunction is potentially associated with FαMNs decrease and NRG1-ErbB4 signaling inhibition in spinal cord in amyotrophic lateral sclerosis. (2023/12/28) ♡
- A cell type-aware framework for nominating non-coding variants in Mendelian regulatory disorders. (2023/12/27) ♡
- Diagnosis of amyotrophic lateral sclerosis by respiratory function test. (2023/12/27) ♡
- A Brain-Controlled Quadruped Robot: A Proof-of-Concept Demonstration. (2023/12/22) ♡
- Unsupervised machine learning identifies distinct ALS molecular subtypes in post-mortem motor cortex and blood expression data. (2023/12/21) ♡
- Rare variant analyses validate known ALS genes in a multi-ethnic population and identifies ANTXR2 as a candidate in PLS. (2023/12/21) ♡
- Reconstitution of C9orf72 GGGGCC repeat-associated non-AUG translation with purified human translation factors. (2023/12/20) ♡
- Efficient generation of a self-organizing neuromuscular junction model from human pluripotent stem cells. (2023/12/19) ♡
- Engineering three-dimensional bone macro-tissues by guided fusion of cell spheroids. (2023/12/19) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Diagnosis and differential diagnosis of MND/ALS: IFCN handbook chapter. (2023/12/19) ♡
- Targeting RACK1 to alleviate TDP-43 and FUS proteinopathy-mediated suppression of protein translation and neurodegeneration. (2023/12/18) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Neurofilaments in health and Charcot-Marie-Tooth disease. (2023/12/18) ♡
- Dysregulation of innate immune signaling in animal models of Spinal Muscular Atrophy. (2023/12/15) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Dental Management of Patients With Amyotrophic Lateral Sclerosis. (2023/12/15) ♡
- Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Newborn Screening for Spinal Muscular Atrophy: A 2.5-Year Experience in Hyogo Prefecture, Japan. (2023/12/14) ♡
- Structural Integrity of Nucleolin Is Required to Suppress TDP-43-Mediated Cytotoxicity in Yeast and Human Cell Models. (2023/12/14) ♡
- Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. "When Will All of This End?": A 65-Year-Old Man With Amyotrophic Lateral Sclerosis and Psychiatric Distress. (2023/12/13) ♡
- The Intense Psychological Burden of ALS, the Enduring Strength of People Living With ALS, and the Tools We Can Use to Help. (2023/12/13) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Mitochondrial Quality Control via Mitochondrial Unfolded Protein Response (mtUPR) in Ageing and Neurodegenerative Diseases. (2023/12/13) ♡
- Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. The genetic puzzle of a SOD1-patient with ocular ptosis and a motor neuron disease: a case report. (2023/12/13) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. History of ALS and the competing theories on pathogenesis: IFCN handbook chapter. (2023/12/12) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Metformin: The Winding Path from Understanding Its Molecular Mechanisms to Proving Therapeutic Benefits in Neurodegenerative Disorders. (2023/12/11) ♡
- Explore the pharmacological basis of ShengJiYiSui decoction in the treatment of amyotrophic lateral sclerosis based on network pharmacology and molecular docking technology. (2023/12/10) ♡
- Disruption of Mitophagy Flux through the PARL-PINK1 Pathway by CHCHD10 Mutations or CHCHD10 Depletion. (2023/12/07) ♡
- Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Cohort analysis of novel SPAST variants in SPG4 patients and implementation of in vitro and in vivo studies to identify the pathogenic mechanism caused by splicing mutations. (2023/12/07) ♡
- Non-motor symptoms in motor neuron disease: prevalence, assessment and impact. (2023/12/07) ♡
- Motor fiber function in spinal muscular atrophy-analysis of conduction velocity distribution. (2023/12/07) ♡
- Work-related factors and risk of amyotrophic lateral sclerosis: A multivariable Mendelian randomization study. (2023/12/01) ♡
- Association Between Fat Depletion and Prognosis of Amyotrophic Lateral Sclerosis: CT-Based Body Composition Analysis. (2023/12/01) ♡
- Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Predictors for progression in amyotrophic lateral sclerosis associated to SOD1 mutation: insight from two population-based registries. (2023/12/01) ♡
- Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. MLKL deficiency alleviates neuroinflammation and motor deficits in the α-synuclein transgenic mouse model of Parkinson's disease. (2023/12/01) ♡
- Quantitative Image Analysis of Axonal Morphology in In Vivo Model. (2023/12/01) ♡
- Commentary or editorialiAn expert's opinion or commentary, not new research. The importance of patient-centred drug development for amyotrophic lateral sclerosis. (2023/12/01) ♡
- Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Spinal cord compression from malignant relapsed Hodgkin's lymphoma presenting with neurological symptoms - Case report. (2023/12/01) ♡
- Anti-Inflammatory Effects of Chaenomeles sinensis Extract in an ALS Animal Model. (2023/12/01) ♡
- Attenuation of amyotrophic lateral sclerosis via stem cell and extracellular vesicle therapy: An updated review. (2023/12/01) ♡
- Randomized researchiParticipants were divided into groups by lottery and compared with each other. This reduces the chance that a difference is due to something other than the treatment. Add-on treatment with Cerebrolysin improves clinical symptoms in patients with ALS: results from a prospective, single-center, placebo-controlled, randomized, double-blind, phase II study. (2023/12/01) ♡
- Pain in Children and Adolescents with Spinal Muscular Atrophy: A Longitudinal Study from a Patient Registry. (2023/11/30) ♡
- Real-Time PCR-Based Screening for Homozygous SMN2 Deletion Using Residual Dried Blood Spots. (2023/11/29) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. NUP85 as a Neurodevelopmental Gene: From Podocyte to Neuron. (2023/11/27) ♡
- Neutrophil to Lymphocyte Ratio as a Prognostic Marker in Amyotrophic Lateral Sclerosis. (2023/11/23) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Plastic Spinal Motor Circuits in Health and Disease. (2023/11/23) ♡
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