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Primary lateral sclerosis

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Search Period All yearsLast 12 monthsLast 5 years Topic All topicsGeneralNutrition and dietAlternative treatment methods Type of research Any type of researchHighest evidence only (123)Meta-analysis (29)Treatment guideline (6)Systematic review (51)Randomized controlled trial (19)Phase 3 study (18)Clinical trial (658)Review article (337)Early-stage study (phase 1 or 2) (13)Laboratory or animal research (123)Case description (120)Commentary or editorial (46)Retracted publication (1) Studies currently recruiting participants only (31)

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Publications and studies (2510)

• Investigation of the mechanism of action of deep brain stimulation for the treatment of Parkinson's disease. (2024/04/01) ♡
• Network pharmacology analysis and clinical efficacy of the traditional Chinese medicine Bu-Shen-Jian-Pi. Part 1: Biogenic components and identification of targets and signaling pathways in amyotrophic lateral sclerosis patients. (2024/04/01) ♡
• Randomized researchiParticipants were divided into groups by lottery and compared with each other. This reduces the chance that a difference is due to something other than the treatment. Network pharmacology analysis and clinical efficacy of the traditional Chinese medicine Bu-Shen-Jian-Pi. Part 3: Alleviation of hypoxia, muscle-wasting, and modulation of redox functions in amyotrophic lateral sclerosis. (2024/04/01) ♡
• Dietary NMN supplementation enhances motor and NMJ function in ALS. (2024/04/01) ♡
• Clinical prognostic factors predicting survival of motor neuron disease patients with gastrostomy: A retrospective analysis. (2024/04/01) ♡
• Prognostic value of geriatric nutritional risk index in patients with amyotrophic lateral sclerosis. (2024/04/01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Use of Muscle Ultrasonography in Morphofunctional Assessment of Amyotrophic Lateral Sclerosis (ALS). (2024/03/31) ♡
• Timing and impact of percutaneous endoscopic gastrostomy insertion in patients with amyotrophic lateral sclerosis: a comprehensive analysis. (2024/03/26) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Disruption of Neuromuscular Junction Following Spinal Cord Injury and Motor Neuron Diseases. (2024/03/20) ♡
• Randomized researchiParticipants were divided into groups by lottery and compared with each other. This reduces the chance that a difference is due to something other than the treatment. Sunitinib for metastatic progressive phaeochromocytomas and paragangliomas: results from FIRSTMAPPP, an academic, multicentre, international, randomised, placebo-controlled, double-blind, phase 2 trial. (2024/03/16) ♡
• Constipation in patients with motor neuron disease: A retrospective longitudinal study. (2024/03/13) ♡
• Analysis of C9orf72 repeat expansions in Georgian patients with Amyotrophic lateral sclerosis (ALS). (2024/03/06) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. The role of artificial intelligence in electrodiagnostic and neuromuscular medicine: Current state and future directions. (2024/03/01) ♡
• Quantitative muscle ultrasound in adult spinal muscular atrophy. A pilot study. (2024/03/01) ♡
• Nuclear pore pathology underlying multisystem proteinopathy type 3-related inclusion body myopathy. (2024/03/01) ♡
• Multiplex Real-Time PCR-Based Newborn Screening for Severe Primary Immunodeficiency and Spinal Muscular Atrophy in Osaka, Japan: Our Results after 3 Years. (2024/02/28) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Neuroprotective Effects of the Nutraceutical Dehydrozingerone and Its C(2)-Symmetric Dimer in a Drosophila Model of Parkinson's Disease. (2024/02/24) ♡
• Electroacupuncture at ST25 corrected gut microbial dysbiosis and SNpc lipid peroxidation in Parkinson's disease rats. (2024/02/21) ♡
• Impact of the COVID-19 Pandemic on People Living With Rare Diseases and Their Families: Results of a National Survey. (2024/02/14) ♡
• Right Brain: The Strangeness of a Good Diagnosis. (2024/02/13) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Asymmetric and extensive pyramidal tract lesion in subacute combined degeneration. (2024/02/01) ♡
• The value of routine blood work-up in clinical stratification and prognosis of patients with amyotrophic lateral sclerosis. (2024/02/01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Higher Glycemic Index and Glycemic Load Diet Is Associated with Slower Disease Progression in Amyotrophic Lateral Sclerosis. (2024/02/01) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Generation of a human induced pluripotent stem cell line (SMUSHi002-A) from an ALS patient carrying a heterozygous mutation c.1562G > A in the FUS gene. (2024/02/01) ♡
• A neurophysiological approach to mirror movements in amyotrophic lateral sclerosis. (2024/02/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Generation of two induced pluripotent stem cell lines from two sporadic amyotrophic lateral sclerosis patients. (2024/02/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Novel approaches to motoneuron disease/ALS treatment using non-invasive brain and spinal stimulation: IFCN handbook chapter. (2024/02/01) ♡
• Rubusoside mitigates neuroinflammation and cellular apoptosis in Parkinson's disease, and alters gut microbiota and metabolite composition. (2024/02/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Degenerative Cervical Myelopathy: A Concept Review and Clinical Approach. (2024/02/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Malnutrition in Spinal Muscular Atrophy Type I: Case Report of a Novel Nutritional Intervention With Improved Growth and Function While Receiving Parallel Gene Splicing Therapies. (2024/02/01) ♡
• Effect of nusinersen after 3 years of treatment in 57 young children with SMA in terms of SMN2 copy number or type. (2024/02/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Challenges and opportunities in spinal muscular atrophy therapeutics. (2024/02/01) ♡
• Leptin haploinsufficiency exerts sex-dependent partial protection in SOD1(G93A) mice by reducing inflammatory pathways in the adipose tissue. (2024/02/01) ♡
• MATR3 pathogenic variants differentially impair its cryptic splicing repression function. (2024/02/01) ♡
• Carbon disulfide induces accumulation of TDP-43 in the cytoplasm and mitochondrial dysfunction in rat spinal cords. (2024/01/31) ♡
• IL-11 ameliorates oxidative stress damage in neurons after spinal cord injury by activating the JAK/STAT signaling pathway. (2024/01/25) ♡
• Nutritional, Clinical and Sociodemographic Profiles of Spanish Patients with Amyotrophic Lateral Sclerosis. (2024/01/25) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Structural and Functional Brain Network Connectivity at Different King's Stages in Patients With Amyotrophic Lateral Sclerosis. (2024/01/23) ♡
• Observing Patterns in MRI With QSM in Patients With SOD1 Genetic ALS (5047). (2024/01/23) ♡
• Analyzing the ER stress response in ALS patient derived motor neurons identifies druggable neuroprotective targets. (2024/01/19) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Time-restricted ketogenic diet in amyotrophic lateral sclerosis: a case study. (2024/01/18) ♡
• Reduction of inflammation and mitochondrial degeneration in mutant SOD1 mice through inhibition of voltage-gated potassium channel Kv1.3. (2024/01/16) ♡
• Aggregation of E121K mutant D-amino acid oxidase and ubiquitination-mediated autophagy mechanisms leading to amyotrophic lateral sclerosis. (2024/01/15) ♡
• A high-fidelity long-read sequencing-based approach enables accurate and effective genetic diagnosis of spinal muscular atrophy. (2024/01/15) ♡
• Genetic analyses identify brain imaging-derived phenotypes associated with the risk of amyotrophic lateral sclerosis. (2024/01/14) ♡
• Towards a Machine Learning Empowered Prognostic Model for Predicting Disease Progression for Amyotrophic Lateral Sclerosis. (2024/01/11) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Clinical, Imaging, Genetic, and Disease Course Characteristics in Patients With GM2 Gangliosidosis: Beyond Age of Onset. (2024/01/09) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Autophagy in spinal muscular atrophy: from pathogenic mechanisms to therapeutic approaches. (2024/01/08) ♡
• Micropopulation mapping of the mouse parafascicular nucleus connections reveals diverse input-output motifs. (2024/01/08) ♡
• Electromyography varies by stage in inclusion body myositis. (2024/01/05) ♡

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