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Primary lateral sclerosis
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Publications and studies (2508)
- Release of FUS into the extracellular space is regulated by its amino-terminal prion-like domain. (2025/04/01) ♡
- Loss of Insight in Syndromes Associated with Frontotemporal Lobar Degeneration: Clinical and Imaging Features. (2025/04/01) ♡
- Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Dual-tDCS Ameliorates Cerebral Injury and Promotes Motor Function Recovery via cGAS-STING Signaling Pathway in a Rat Model of Ischemic Stroke. (2025/04/01) ♡
- Associations of dietary factors with amyotrophic lateral sclerosis: A Mendelian randomization study. (2025/04/01) ♡
- Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Lysosomal Dysfunction in Amyotrophic Lateral Sclerosis: A Familial Case Linked to the p.G376D TARDBP Mutation. (2025/03/21) ♡
- Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Changes in sensory and motor neurons populations following LPC-induced sciatic nerve demyelination in rats: A study using CTB retrograde tracing. (2025/03/17) ♡
- Electroacupuncture promotes neural function recovery by alleviating mitochondria damage in cerebral ischemia mice. (2025/03/15) ♡
- Validation of the Caregiver Analysis of Reported Experiences with Swallowing Disorders (CARES) Screening Tool for Neurodegenerative Disease. (2025/03/10) ♡
- How Amyotrophic Lateral Sclerosis Contributes to Increased Venous Thromboembolism Risk. (2025/03/05) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Swallowing function in patients with spinal muscular atrophy before and after the introduction of new gene-based therapies: what has changed? (2025/03/01) ♡
- Clinician Perspectives Highlight the Need for Early Dyadic Coping Skills for People Living With Amyotrophic Lateral Sclerosis. (2025/03/01) ♡
- Longitudinal Efficacy of Nusinersen Treatment on Health-Related Quality of Life and Independence in Children With Later-Onset Spinal Muscular Atrophy. (2025/03/01) ♡
- Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Effects of ALS-associated 5'tiRNA(Gly-GCC) on the transcriptomic and proteomic profile of primary neurons in vitro. (2025/03/01) ♡
- Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Risdiplam in Adult Patients With 5q Spinal Muscular Atrophy: A Single-Center Longitudinal Study. (2025/03/01) ♡
- Dysregulation of synaptic transcripts underlies network abnormalities in ALS patient-derived motor neurons. (2025/03/01) ♡
- Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Generation of an induced pluripotent stem cell line from a Kennedy Disease patient with AR mutation. (2025/03/01) ♡
- Analysis of spinal muscular atrophy patients from the spinal muscular atrophy and muscular dystrophy registry of Pakistan. (2025/03/01) ♡
- Detection of motor nervous disease using deep learning based Duple feature extraction network. (2025/03/01) ♡
- Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Effects of Electroacupuncture on Syt3 and GluA2 in Rats With Limb Spasms After Intracerebral Hemorrhage. (2025/03/01) ♡
- Italian survey on evolving SMA care with disease-modifying therapies: a consensus workshop on nutrition, swallowing, respiratory and rehabilitation care. (2025/03/01) ♡
- Systematic reviewiAll research on one question is searched according to fixed rules and compared side by side, so that no studies with poor outcomes are missed. Systematic literature review of the impact of spinal muscular atrophy therapies on bulbar function. (2025/03/01) ♡
- Monoaminergic Alterations at the Subregional Cervical and Thoracic Spinal Cord Level of Patients Within the FTD-ALS Continuum and Early-Onset AD: Low Thoracic Dopaminergic Activity in ALS. (2025/03/01) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Advancements in genetic research and RNA therapy strategies for amyotrophic lateral sclerosis (ALS): current progress and future prospects. (2025/02/26) ♡
- Systematic reviewiAll research on one question is searched according to fixed rules and compared side by side, so that no studies with poor outcomes are missed. Evidence-Based Nutritional Recommendations for Maintaining or Restoring Nutritional Status in Patients with Amyotrophic Lateral Sclerosis: A Systematic Review. (2025/02/24) ♡
- Cardio-metabolic and cytoskeletal proteomic signatures differentiate stress hypersensitivity in dystrophin-deficient mdx mice. (2025/02/20) ♡
- Clinical features of FOSMN syndrome in Korea: A comparative analysis with bulbar-onset amyotrophic lateral sclerosis. (2025/02/15) ♡
- Herbal Medicine Extracts Improve Motor Function by Anti-Inflammatory Activity in hSOD1(G93A) Animal Model. (2025/02/13) ♡
- Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Case report: A severe myositis mimicking bulbar palsy after administration of immune checkpoint inhibitors. (2025/02/10) ♡
- Electroacupuncture alleviates motor dysfunction after intracerebral hemorrhage via the PPARγ-EAAT2 pathway. (2025/02/05) ♡
- The Ile35 Residue of the ALS-Associated Mutant SOD1 Plays a Crucial Role in the Intracellular Aggregation of the Molecule. (2025/02/01) ♡
- Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Effect of Nusinersen on Respiratory and Bulbar Function in Children with Spinal Muscular Atrophy: Real-World Experience from a Single Center. (2025/02/01) ♡
- Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Blood glycated hemoglobin level is not associated with disease progression in amyotrophic lateral sclerosis. (2025/02/01) ♡
- ALSUntangled #76: Wahls protocol. (2025/02/01) ♡
- Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. CMT2 and distal hereditary motor neuropathy associated with VRK1 variants: Case series. (2025/02/01) ♡
- Systematic reviewiAll research on one question is searched according to fixed rules and compared side by side, so that no studies with poor outcomes are missed. Current evidence of arterial spin labeling in amyotrophic lateral sclerosis: A systematic review. (2025/02/01) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Novel biallelic nonsense mutation in IGHMBP2 gene linked to neuropathy (CMT2S): A comprehensive clinical, genetic and bioinformatic analysis of a Turkish patient with literature review. (2025/02/01) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Iron(ing) out parkinsonisms: The interplay of proteinopathy and ferroptosis in Parkinson's disease and tau-related parkinsonisms. (2025/02/01) ♡
- Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi007-A) from a patient with Kennedy disease. (2025/02/01) ♡
- Scoliosis development in 5q-spinal muscular atrophy under disease modifying therapies. (2025/02/01) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Zebrafish as a model to understand extraocular motor neuron diversity. (2025/02/01) ♡
- Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. The influence of genotype on the natural history of types 1 - 3 spinal muscular atrophy. (2025/02/01) ♡
- Electroacupuncture ameliorated locomotor symptoms in MPTP-induced mice model of Parkinson's disease by regulating autophagy via Nrf2 signaling. (2025/02/01) ♡
- Association between serum copper concentration and body composition in children with spinal muscular atrophy: a cross-sectional study. (2025/02/01) ♡
- Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Longer disease progression milestone-free time in people with amyotrophic lateral sclerosis treated versus not treated with intravenous edaravone: results from an administrative claims analysis. (2025/02/01) ♡
- Phase 3 studyiResearch in a large group of patients, the final step before a treatment can be approved. What comes out here carries significant weight. Safety and Efficacy of IV Onasemnogene Abeparvovec for Pediatric Patients With Spinal Muscular Atrophy: The Phase 3b SMART Study. (2025/01/28) ♡
- Polyamine metabolism dysregulation contributes to muscle fiber vulnerability in ALS. (2025/01/28) ♡
- Enhanced bioavailability of Quercetin-loaded niosomal in situ gel for the management of Parkinson's disease. (2025/01/27) ♡
- Manganese exposure induces parkinsonism-like symptoms by Serpina3n-TFEB-v/p-ATPase signaling mediated lysosomal dysfunction. (2025/01/23) ♡
- Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Long-term lung volume recruitment therapy maintains ventilator weaning in a patient with ALS following tracheostomy. (2025/01/19) ♡
- Rapid and relaying deleterious effects of a gastrointestinal pathogen, Citrobacter rodentium, on bone, an extra-intestinal organ. (2025/01/16) ♡
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