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Primary lateral sclerosis
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Publications and studies (2510)
- Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. A Study to Learn More About the Long-Term Safety of Tofersen (Qalsody) in Chinese Participants With SOD-1 Amyotrophic Lateral Sclerosis (ALS) (2026-01-20) ♡
- Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. A Physiotherapy Intervention Study in Patients With Amyotrophic Lateral Sclerosis (ALS) (2026-01-15) ♡
- Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Control Cohort CTRL COH (2026-01-15) ♡
- Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. The NO-ALS Study: A Trial of Nicotinamide/Pterostilbene Supplement in ALS. (2026-01-12) ♡
- Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Identifying Biomarkers in ALS Patients Using Neuronal Derived Extracellular Vesicles (2026-01-12) ♡
- Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Atalante Exoskeleton in the Rehabilitation of Patients With Amyotrophic Lateral Sclerosis (2026-01-12) ♡
- Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Precise Robotically IMplanted Brain-Computer InterfacE (2026-01-09) ♡
- Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Amyotrophic Lateral Sclerosis (ALS) Families Project (2026-01-07) ♡
- Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. This Study Evaluates the Safety, Target Engagement, and Preliminary Efficacy of Galunisertib (TGF-βR1/ALK5 Inhibitor)Combined With Nerandomilast (PDE4 Inhibitor) in GREM2-positive ALS, a Biomarker-defined Subgroup Hypothesized to Reflect Heightened TGF-β/SMAD-driven Astrocytic and Fibrotic Signaling (2026-01-07) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Expanding the neurological spectrum of HTLV-1 beyond HAM/TSP: a contemporary perspective. (2025/12/31) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Glutamate Receptor Agonists as Triggers of Neurotoxicity: Decoding Pathways of Five Neurotoxins and Potential Therapeutic Targets. (2025/12/31) ♡
- Polygenic associations with clinical and neuropathological trait heterogeneity across TDP-43 proteinopathies. (2025/12/30) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Establishing Diagnostic and Differential Diagnostic Criteria for Amyotrophic Lateral Sclerosis. (2025/12/30) ♡
- LINE-1 retrotransposition in a mouse TDP-43 model of neurodegeneration marks motor cortex neurons for cell-intrinsic and cell non-autonomous programmed cell death. (2025/12/29) ♡
- Spatiotemporal dynamics of neuronal subtypes and their interactions with glia following intracortical electrode implantation. (2025/12/29) ♡
- Commentary or editorialiAn expert's opinion or commentary, not new research. ALS: a field in motion. (2025/12/29) ♡
- Short-Term Effects of Exercise Therapy on Muscle Characteristics in Patients With Mild-to-Moderate Amyotrophic Lateral Sclerosis: A Preliminary Case Series Study. (2025/12/29) ♡
- Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. A mouse model of CHCHD10 p.R15L familial ALS presents mild, age-related motor neuron degeneration without protein instability or mitochondrial dysfunction. (2025/12/29) ♡
- Preventing spinal muscular atrophy through the national premarital screening program in Türkiye: an economic comparison with treatment costs. (2025/12/28) ♡
- Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Integrative behavioral, histological, and proteomics profiling identifies cerebellar drivers of motor dysfunction in a rat model of hepatic encephalopathy. (2025/12/27) ♡
- Effectiveness and safety of Risdiplam for types 1-3 spinal muscular atrophy in a single center. (2025/12/26) ♡
- PBX-dependent and independent Hox programs establish and maintain motor neuron terminal Identity. (2025/12/26) ♡
- Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Multilevel Screening Platform Utilizing Cellular and Zebrafish Models to Identify Short Peptides with High Improvement of Motor Neuron Growth. (2025/12/26) ♡
- mGluR4-NPDC1 complex mediates α-synuclein fibril-induced neurodegeneration. (2025/12/25) ♡
- Human midbrain organoids reveal the characteristics of axonal mitochondria specific to dopaminergic neurons. (2025/12/25) ♡
- Detection of inflammation and glial cell-related biomarkers in adults with spinal muscular atrophy receiving nusinersen therapy. (2025/12/25) ♡
- Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. [Effect of formononetin on endoplasmic reticulum stress and neuronal apoptosis in rats with chronic compressive cervical spinal cord injury]. (2025/12/25) ♡
- Loss of Y chromosome and its implications in male amyotrophic lateral sclerosis: insights from the UK Biobank. (2025/12/24) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. A Comprehensive Overview of Neurophysiological Correlates of Cognitive Impairment in Amyotrophic Lateral Sclerosis. (2025/12/24) ♡
- Body Weight and Range of Motion as Predictors of Trunk Asymmetry in Children With Spinal Muscular Atrophy: A Prospective Functional Assessment. (2025/12/23) ♡
- Parkinsonism Reversal and Dopaminergic Resilience: Lessons from a Rotenone-induced Parkinson's Disease Model. (2025/12/23) ♡
- Carrier screening for multiple complex monogenic diseases using long-read sequencing: a population-based study of premarital couples in Shanghai. (2025/12/22) ♡
- Lysosomal escape and TMEM106B fibrillar core determine TDP-43 seeding outcomes. (2025/12/22) ♡
- Multidimensional Characterization of Parkinson's Disease Subtypes Through Motor Neuron Excitability and Peripheral Immune Dynamics: Insights from F-Wave Modulation Metrics. (2025/12/22) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Cellular and Molecular Mechanisms of Neuroprotection in Deep Brain Stimulation for Parkinson's Disease. (2025/12/21) ♡
- Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Awake Rat Model of Ischemic Stroke with Neuropsychiatric Complications During a Seven-Day Observation. (2025/12/19) ♡
- Primate-specific adaptation of Ku protects transcriptomic integrity by suppressing Alu-mediated alternative splicing. (2025/12/18) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. GLP-1 Signalling as a Therapeutic Avenue in Parkinson's Disease: A Comprehensive Review. (2025/12/18) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Amyotrophic Lateral Sclerosis With Concurrent LHON-associated m.14484T>C Mutation: A Case Report and Literature Review. (2025/12/18) ♡
- Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Preclinical Evaluation of the Assembly Modulator PAV-615 in a Mouse Model of C9orf72-Associated ALS/FTD. (2025/12/17) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. The application of fecal microbiota transplantation in Parkinson's disease. (2025/12/17) ♡
- Cross-species consensus atlas of the primate basal ganglia. (2025/12/16) ♡
- Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Identification of myokymia in adult-onset hereditary spastic paraplegia type 79A: Implications for the phenotypic spectrum. (2025/12/15) ♡
- Neuroplastic Effects Induced by Hypercapnic Hypoxia in Rat Focal Ischemic Stroke Are Driven via BDNF and VEGF Signaling. (2025/12/13) ♡
- TMT-based quantitative proteomic assessment of Vicia sativa induced neurotoxicity by β-cyano-L-alanine and γ-glutamyl-β-cyano-L-alanine in SH-SY5Y cells. (2025/12/11) ♡
- Aqueous Extract of Bacopa procumbens and the NAPEL Formulation Mitigate MPTP-Induced Neurotoxicity via Nrf2/HSF1/HIF-1α Signaling in a Parkinson's Disease Model. (2025/12/10) ♡
- Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. [Clinical characteristics and genetic analysis of a patient with Kennedy disease with secondary infertility as the initial symptom]. (2025/12/10) ♡
- Prevalence and Clinical Associations of A-Waves in Routine Nerve Conduction Studies: A Retrospective Analysis. (2025/12/08) ♡
- Combined Histological and Proteomic Analysis Reveals Muscle Denervation in KMT5B-Related Neurodevelopmental Disorder: A Case Report. (2025/12/05) ♡
- ABCA1 acts as a protective modulator in amyotrophic lateral sclerosis. (2025/12/03) ♡
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