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Lewy body dementia
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Publications and studies (1347)
- Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Protease-Sensitive and -Resistant Forms of Human and Murine Alpha-Synucleins in Distinct Brain Regions of Transgenic Mice (M83) Expressing the Human Mutated A53T Protein. (2023/12/13) ♡
- Glucocerebrosidase deficiency leads to neuropathology via cellular immune activation. (2023/12/13) ♡
- Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Frequency of Orthostatic Hypotension in Isolated REM Sleep Behavior Disorder. (2023/12/12) ♡
- Dementia subtypes, cognitive decline and survival among older adults attending a memory clinic in Cape Town, South Africa: a retrospective study. (2023/12/09) ♡
- Development and validation of an expanded antibody toolset that captures alpha-synuclein pathological diversity in Lewy body diseases. (2023/12/07) ♡
- Disease progression modelling reveals heterogeneity in trajectories of Lewy-type α-synuclein pathology. (2023/12/07) ♡
- α-Synuclein emulsifies TDP-43 prion-like domain-RNA liquid droplets to promote heterotypic amyloid fibrils. (2023/12/05) ♡
- (13)C and (15)N resonance assignments of alpha synuclein fibrils amplified from Lewy Body Dementia tissue. (2023/12/01) ♡
- Meta-analysisiAll studies on one question combined and calculated together. This is the strongest form of research that exists: a single loose study can be coincidence, dozens together much less so. The label says something about the design, not about the outcome — which can also be that something does NOT work. Transcranial magnetic stimulation neurophysiology in patients with non-Alzheimer's neurodegenerative diseases: A systematic review and meta-analysis. (2023/12/01) ♡
- Autonomic dysregulation during sleep in Parkinsonian spectrum disorders - A proof of concept. (2023/12/01) ♡
- Effective connectivity abnormalities in Lewy body disease with visual hallucinations. (2023/12/01) ♡
- Proteomic comparison between non-purified cerebrospinal fluid and cerebrospinal fluid-derived extracellular vesicles from patients with Alzheimer's, Parkinson's and Lewy body dementia. (2023/12/01) ♡
- Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Young-onset dementia with Lewy Bodies presenting with apathy and alexithymia. (2023/12/01) ♡
- Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. USP19 deubiquitinase inactivation regulates α-synuclein ubiquitination and inhibits accumulation of Lewy body-like aggregates in mice. (2023/11/28) ♡
- Neuronal SNCA transcription during Lewy body formation. (2023/11/23) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Clinical biomarkers for Lewy body diseases. (2023/11/14) ♡
- NeuroBooster Array: A Genome-Wide Genotyping Platform to Study Neurological Disorders Across Diverse Populations. (2023/11/14) ♡
- Heterogeneity of cortical pTDP-43 inclusion morphologies in amyotrophic lateral sclerosis. (2023/11/13) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Extracellular vesicles from bodily fluids for the accurate diagnosis of Parkinson's disease and related disorders: A systematic review and diagnostic meta-analysis. (2023/11/13) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Protein Biomarkers Shared by Multiple Neurodegenerative Diseases Are Calmodulin-Binding Proteins Offering Novel and Potentially Universal Therapeutic Targets. (2023/11/11) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Peptide-based approaches to directly target alpha-synuclein in Parkinson's disease. (2023/11/09) ♡
- Pareidolias are a function of visuoperceptual impairment. (2023/11/06) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Pharmacogenomics of Dementia: Personalizing the Treatment of Cognitive and Neuropsychiatric Symptoms. (2023/11/06) ♡
- Loss of Lipid Carrier ApoE Exacerbates Brain Glial and Inflammatory Responses after Lysosomal GBA1 Inhibition. (2023/11/02) ♡
- Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Progressive supranuclear palsy: A case report and brief review of the literature. (2023/11/02) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Elucidating distinct molecular signatures of Lewy body dementias. (2023/11/01) ♡
- Dementia: Dementia Types. (2023/11/01) ♡
- Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Formation of templated inclusions in a forebrain α-synuclein mouse model is independent of LRRK2. (2023/11/01) ♡
- Current evidence on the association of tongue strength with cognitive decline in older adults and the known risk factors of frailty, sarcopenia and nutritional health: a scoping review protocol. (2023/10/28) ♡
- Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. α-Synuclein aggregates amplified from patient-derived Lewy bodies recapitulate Lewy body diseases in mice. (2023/10/28) ♡
- Investigation of the genetic aetiology of Lewy body diseases with and without dementia. (2023/10/27) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Cerebrospinal fluid ubiquitin as a biomarker for neurodegenerative diseases: A systematic review. (2023/10/23) ♡
- Investigating the Pathogenic Interplay of Alpha-Synuclein, Tau, and Amyloid Beta in Lewy Body Dementia: Insights from Viral-Mediated Overexpression in Transgenic Mouse Models. (2023/10/22) ♡
- Computational analysis of five neurodegenerative diseases reveals shared and specific genetic loci. (2023/10/21) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Secondary Protein Aggregates in Neurodegenerative Diseases: Almost the Rule Rather than the Exception. (2023/10/20) ♡
- Factors affecting progression of non-Alzheimer dementia: a retrospective analysis with long-term follow-up. (2023/10/18) ♡
- Specific neuropsychiatric symptoms are associated with functional decline trajectories in Alzheimer's disease and Lewy body dementia: a five-year follow-up study. (2023/10/17) ♡
- Genome-wide association study identifies APOE and ZMIZ1 variants as mitophagy modifiers in Lewy body disease. (2023/10/16) ♡
- Investigation of the causal relationship between osteocalcin and dementia: A Mendelian randomization study. (2023/10/16) ♡
- Developing a core outcome set (COS) for Dementia with Lewy bodies (DLB). (2023/10/10) ♡
- Wake and non-rapid eye movement sleep dysfunction is associated with colonic neuropathology in Parkinson's disease. (2023/10/04) ♡
- Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Pimavanserin Use in Lewy Body Dementia: A Case Report Demonstrating the Medication's Efficacy. (2023/10/02) ♡
- Consensus recommendations for clinical assessment tools for the diagnosis of posterior cortical atrophy syndrome from the Atypical AD PIA of ISTAART. (2023/09/20) ♡
- Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Prodromal Dementia with Lewy Bodies: A Case Series of the 3 Prodromal Types from Clinical Practice. (2023/08/11) ♡
- A 14-day pulse of PLX5622 modifies α-synucleinopathy in preformed fibril-infused aged mice of both sexes. (2023/08/01) ♡
- Meta-analysisiAll studies on one question combined and calculated together. This is the strongest form of research that exists: a single loose study can be coincidence, dozens together much less so. The label says something about the design, not about the outcome — which can also be that something does NOT work. Blood Biomarkers for the Diagnosis of Neurodegenerative Dementia: A Systematic Review. (2023/07/01) ♡
- Hypertension and cognitive dysfunction: a narrative review. (2023/07/01) ♡
- Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. A Case Report of Treatment-Resistant Agitation in Dementia With Lewy Bodies: Medical Marijuana as an Alternative to Antipsychotics. (2023/05/01) ♡
- Prioritization of Drug Targets for Neurodegenerative Diseases by Integrating Genetic and Proteomic Data From Brain and Blood. (2023/05/01) ♡
- Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Dietary Trace Elements and the Pathogenesis of Neurodegenerative Diseases. (2023/04/25) ♡
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