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Chronic kidney disease, stage 4-5

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Search Period All yearsLast 12 monthsLast 5 years Topic All topicsGeneralNutrition and dietAlternative treatment methods Type of research Any type of researchHighest level evidence only (171)Meta-analysis (31)Treatment guideline (9)Randomized controlled trial (79)Systematic review (35)Phase 3 study (17)Clinical trial (146)Review article (468)Early-stage study (phase 1 or 2) (13)Case description (154)Laboratory or animal research (105)Commentary or editorial (59)Retracted Publication (4) Studies currently recruiting participants only (55)

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Publications and studies (2797)

• Phase 3 studyiResearch in a large group of patients, the final step before a treatment can be approved. What comes out here carries significant weight. Niaoduqing Granules in Older Adults With Impaired Kidney Function (2026-08-03) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Real-World Study of Enarodustat for Anemia in Non-Dialysis CKD Patients (2026-08-03) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Primary Palliative Care - a Feasibility Cluster Trial (2026-08-03) ♡
• Early-stage study (phase 1 or 2)iEarly research in a small group, primarily aimed at safety and dosage. Whether it actually works still needs to be determined afterward. Pharmacokinetics of Zoledronic Acid in Patients on Dialysis (2026-08-03) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Kidney RISE: Randomized Integrated Supportive CarE Trial (2026-08-03) ♡
• Phase 3 studyiResearch in a large group of patients, the final step before a treatment can be approved. What comes out here carries significant weight. Intensification of Blood Pressure Lowering Therapeutics Based on Diuretics Versus Usual Management for Uncontrolled Hypertension IN Patients With Moderate to Severe Chronic Kidney Disease (2026-08-03) ♡
• Early-stage study (phase 1 or 2)iEarly research in a small group, primarily aimed at safety and dosage. Whether it actually works still needs to be determined afterward. A Study to Evaluate Safety, Tolerability and Efficacy of AP306 at Fixed Doses in Dialysis Participants With Hyperphosphatemia (2026-08-03) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Investigating Vascular Properties of HEMI and SPG Signals in Individuals With or at Risk for Chronic Kidney Disease (2026-07-31) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. The Effect of Patient Empowerment Learning (With AI) About Itching in Hemodialysis Patients. (2026-07-31) ♡
• Phase 3 studyiResearch in a large group of patients, the final step before a treatment can be approved. What comes out here carries significant weight. Tacrolimus/Everolimus vs. Tacrolimus/MMF in Pediatric Heart Transplant Recipients Using the MATE Score (2026-07-31) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Pro-social Power Training Activity for Aging and Well-being With Chronic Kidney Disease (2026-07-31) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Dialysis Less Frequently in the Elderly (2026-07-31) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Association Between Chronic Kidney Disease Stage and Circulating FGF23 Cleavage Intensity in Patients With Chronic Kidney Disease (2026-07-31) ♡
• Phase 3 studyiResearch in a large group of patients, the final step before a treatment can be approved. What comes out here carries significant weight. A Rollover Extension Program (REP) to Evaluate the Long-term Safety and Tolerability of Open Label Iptacopan/LNP023 in Participants With Primary IgA Nephropathy (2026-07-30) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. ECHO for Diabetes and Multiple Chronic Conditions Study (2026-07-30) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. JAK-STAT pathway activation compromises nephrocyte function in a Drosophila high-fat diet model of chronic kidney disease. (2025/12/31) ♡
• A PROSPECTIVE, OBSERVATIONAL STUDY ON ETIOLOGICAL SPECTRUM OF END STAGE KIDNEY DISEASE IN NORTH INDIA: DOMINANCE OF DIABETIC KIDNEY DISEASE AND EMERGING TRENDS. (2025/12/31) ♡
• Sex-Specific Sub-Acute Toxicity and Immunomodulatory Profile of a Nigerian Polyherbal Supplement (Napherbs) In Albino Wistar Rats. (2025/12/31) ♡
• Predictive value of serum chitinase 3-like 1 for dysfunctional autogenous arteriovenous fistulas in patients with chronic kidney disease stage G5. (2025/12/30) ♡
• Fatigue and Related Sleep Disturbances in Hemodialysis Patients: Prevalence, Associated Factors, and the Influence of Nutritional Status. (2025/12/30) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Phosphate and Inflammation in Health and Kidney Disease. (2025/12/30) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Tumoral calcinosis complicating CKD-MBD in hemodialysis: a case report. (2025/12/30) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Prevalence and Incidence of Type 1 Diabetes Among Children and Adults in the United States and Comparison With Other Countries. (2025/12/29) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Sex-related Differences in Health Related Quality of Life Among Hemodialysis Patients: A Systematic Review and Meta Analysis. (2025/12/29) ♡
• Heatwaves, Cold Spells, and Renal Disease Mortality in Japan: Vulnerable Populations and Temporal Trends (1979-2019). (2025/12/29) ♡
• U- and inverted U-shaped link between weight-adjusted waist index and chronic kidney disease in hyperuricemic adults. (2025/12/28) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Human Albumin-enriched Peritoneal Dialysis: A Novel Approach to Manage Refractory Ascites and Kidney Dysfunction in Decompensated Advanced Chronic Liver Disease. (2025/12/28) ♡
• Impact of CKD on Life Participation in Latin America. (2025/12/27) ♡
• Comparing Age- and Sex-Specific Reference Values of eGFR between the United States and Europe. (2025/12/26) ♡
• Exploring the association between pulse wave velocity and CKD progression: a longitudinal study in Mashhad, Iran. (2025/12/26) ♡
• Association Between the Planetary Health Diet Index and Chronic Kidney Disease Prevalence and Mortality: An Analysis of NHANES 2005-2018. (2025/12/26) ♡
• Association between dietary protein intake and all-cause mortality among individuals with different estimated glomerular filtration rates: A cohort study from NHANES. (2025/12/26) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. A retrospective analysis of clinical characteristics and risk factors of renal anemia in elderly patients on maintenance hemodialysis. (2025/12/26) ♡
• CKD-M2 study: 2-year mortality prediction tool for advanced kidney disease. (2025/12/25) ♡
• Clinical characteristics and maternal and fetal outcomes of pregnancy complicated with chronic kidney disease stage 4-5. (2025/12/25) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Dietary management of patients with type 2 diabetes and chronic kidney disease: A comprehensive literature review. (2025/12/25) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Kidney transplant outcomes in obese pediatric patients. (2025/12/25) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. APOL1 G1 and G2 risk alleles modulate severity of diet-induced obesity in a transgenic mouse model. (2025/12/25) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Serum Amyloid A (SAA) and Its Interaction with High-Density Lipoprotein Cholesterol (HDL-C): A Comprehensive Review. (2025/12/25) ♡
• Melatonin Administration Attenuates High-Fat-Diet-Induced Renal Damage in Wistar Rats. (2025/12/25) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Hyperuricemia and elevated creatinine in a child with anemia. (2025/12/25) ♡
• Technical issues in exercise video consultations do not negatively impact exercise intensity for participants with complex chronic conditions: a retrospective audit. (2025/12/24) ♡
• ILK Deletion Protects Against Chronic Kidney Disease-Associated Vascular Damage. (2025/12/24) ♡
• Geographic disparities in kidney function decline: a matched cohort analysis of urban and rural populations in Korea. (2025/12/24) ♡
• Home-Based Exercise Improves Muscle Oxidative Capacity in Kidney Disease. (2025/12/23) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Diabetes in Children and Adolescents. (2025/12/22) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Current Controversies on Adequate Circulating Vitamin D Levels in CKD. (2025/12/22) ♡
• Global Research on Hemodialysis Nutrition and Patient-Centered Priorities: A Bibliometric Analysis (2006-2025). (2025/12/22) ♡
• Increased albuminuria is highly prevalent in the general population: prevalence of CKD in the Gutenberg Health Study. (2025/12/22) ♡
• Randomized researchiParticipants were divided into groups by lottery and compared with each other. This reduces the chance that a difference is due to something other than the treatment. Probiotic Supplementation in Chronic Kidney Disease: Outcomes on Uremic Toxins, Inflammation, and Vascular Calcification from Experimental and Clinical Models. (2025/12/20) ♡

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