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Frontotemporal dementia

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Search Period All yearsLast 12 monthsLast 5 years Topic All topicsGeneralNutrition and dietAlternative treatment methods Type of research Any type of researchOnly the strongest evidence (41)Meta-analysis (10)Treatment guideline (3)Systematic review (21)Phase 3 study (5)Randomized trial (2)Clinical trial (463)Review article (188)Early study (phase 1 or 2) (16)Case report (73)Laboratory or animal research (38)Commentary or editorial (26) Studies currently recruiting participants only (35)

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Publications and studies (1588)

• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Simply crushed zizyphi spinosi semen prevents neurodegenerative diseases and reverses age-related cognitive decline in mice. (2025/04/23) ♡
• The protective role of basal metabolic rate in cognitive decline: evidence from epidemiological and genetic studies. (2025/04/22) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Pathophysiology, Clinical Heterogeneity, and Therapeutic Advances in Amyotrophic Lateral Sclerosis: A Comprehensive Review of Molecular Mechanisms, Diagnostic Challenges, and Multidisciplinary Management Strategies. (2025/04/14) ♡
• Cognitive capacity in amyotrophic lateral sclerosis: the value of diagnostic markers in cerebrospinal fluid and the influence of nutrition and pulmonary function. (2025/04/08) ♡
• Systematic reviewiAll research on one question is searched according to fixed rules and compared side by side, so that no studies with poor outcomes are missed. The pharmacodynamics-based prophylactic benefits of GLP-1 receptor agonists and SGLT2 inhibitors on neurodegenerative diseases: evidence from a network meta-analysis. (2025/04/07) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Targeted protein degradation with bifunctional molecules as a novel therapeutic modality for Alzheimer's disease & beyond. (2025/04/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. NOTCH3 variants of unknown significance underpin vascular dysfunction in neurodegenerative disease: a case series of three nfvPPA-FTD patients. (2025/04/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Heterozygous p62/SQSTM1 mutation and right temporal variant of frontotemporal dementia: Α case report. (2025/04/01) ♡
• Loss of Insight in Syndromes Associated with Frontotemporal Lobar Degeneration: Clinical and Imaging Features. (2025/04/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Double dissociation between lexical decision and comprehension in a Japanese patient with semantic dementia: based on the characteristic processing of Kanji. (2025/04/01) ♡
• Nut consumption is associated with a lower risk of all-cause dementia in adults: a community-based cohort study from the UK Biobank. (2025/04/01) ♡
• Frontotemporal Dementia, Current Diagnosis and Treatment Emphasis on Natural Products: A Review. (2025/03/20) ♡
• 18 F-FDG metabolic abnormalities precede perfusion and atrophic changes in diagnosis of early frontotemporal dementia: study from a tertiary care university hospital. (2025/03/01) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Tau association with synaptic mitochondria coincides with energetic dysfunction and excitatory synapse loss in the P301S tauopathy mouse model. (2025/03/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Alzheimer's Disease Diagnosis and Management in the Age of Amyloid Monoclonal Antibodies. (2025/03/01) ♡
• Depressive Symptoms and Amyloid Pathology. (2025/03/01) ♡
• Monoaminergic Alterations at the Subregional Cervical and Thoracic Spinal Cord Level of Patients Within the FTD-ALS Continuum and Early-Onset AD: Low Thoracic Dopaminergic Activity in ALS. (2025/03/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Multitracer PET/CT Findings in a Case of Behavioral Variant Frontotemporal Dementia With Parkinsonism. (2025/02/01) ♡
• Non-right-handedness, male sex, and regional, network-specific, ventral occipito-temporal anomalous lateralization in adults with a history of reading disability. (2025/02/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Behavioral variant frontotemporal dementia with pathogenic variant in MAPT presenting as dementia with Lewy body disease. (2025/02/01) ♡
• Actigraphy validation in behavioral variant frontotemporal dementia. (2025/02/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Targeting tau in Alzheimer's and beyond: Insights into pathology and therapeutic strategies. (2025/02/01) ♡
• Mild cognitive impairment in spontaneous intracranial hypotension and its rapid reversal by repair of a spinal cerebrospinal fluid leak. (2025/02/01) ♡
• Time-Frequency functional connectivity alterations in Alzheimer's disease and frontotemporal dementia: An EEG analysis using machine learning. (2025/02/01) ♡
• TMEM106B C-terminal fragments aggregate and drive neurodegenerative proteinopathy in transgenic Caenorhabditis elegans. (2025/02/01) ♡
• Factors associated with care-resistant behavior in the National Alzheimer's Coordinating Center's Uniform Data Set. (2025/02/01) ♡
• Psychotropic medication usage in sporadic versus genetic behavioral-variant frontotemporal dementia. (2025/02/01) ♡
• In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds. (2025/02/01) ♡
• Structural inequality linked to brain volume and network dynamics in aging and dementia across the Americas. (2025/02/01) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Introduction to the DETeCD-ADRD special issue. (2025/02/01) ♡
• Linking structural and functional changes during healthy aging and semantic dementia using multilayer brain network analysis. (2025/02/01) ♡
• Meta-analysisiAll studies on one question combined and calculated together. This is the strongest form of research that exists: a single loose study can be coincidence, dozens together much less so. The label says something about the design, not about the outcome — which can also be that something does NOT work. Dementia subtypes and suicidality: A systematic review and meta-analysis. (2025/02/01) ♡
• Data-driven prediction of regional brain metabolism using neuropsychological assessment in Alzheimer's disease and behavioral variant Frontotemporal dementia. (2025/02/01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Relationship of urate-lowering drugs with cognition and dementia: A Mendelian randomization and observational study. (2025/02/01) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Effects of age and dietary methionine restriction on cognitive and behavioural phenotypes in the rTg4510 mouse model of frontotemporal dementia. (2025/02/01) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Clinical Reasoning: A 35-Year-Old Woman With Personality Change and Gait Impairment. (2025/01/28) ♡
• RIPK1 expression and inhibition in tauopathies: implications for neuroinflammation and neuroprotection. (2025/01/27) ♡
• Retinal biomarkers for the risk of Alzheimer's disease and frontotemporal dementia. (2025/01/10) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Searching for new drugs to treat Alzheimer's disease dementia through multiple pathways. (2025/01/06) ♡
• The detection of GRN mutation carriers by progranulin blood protein levels from finger-stick collection. (2025/01/01) ♡
• Skull defect - Frontotemporal dementia sagging brain syndrome. (2025/01/01) ♡
• Laboratory or animal researchiNo research in humans yet. Promising in a test tube or in mice unfortunately means nothing for patients. Examining the potential involvement of NONO in TDP-43 proteinopathy in Drosophila. (2025/01/01) ♡
• Treatment guidelineiAn official agreement between doctors about how this disease should be treated. This is not a single study but the conclusion of an entire medical field. The Alzheimer's Association clinical practice guideline for the diagnostic evaluation, testing, counseling, and disclosure of suspected Alzheimer's disease and related disorders (DETeCD-ADRD): Validated clinical assessment instruments. (2025/01/01) ♡
• Treatment guidelineiAn official agreement between doctors about how this disease should be treated. This is not a single study but the conclusion of an entire medical field. The Alzheimer's Association clinical practice guideline for the Diagnostic Evaluation, Testing, Counseling, and Disclosure of Suspected Alzheimer's Disease and Related Disorders (DETeCD-ADRD): Executive summary of recommendations for specialty care. (2025/01/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Precision diagnosis of cognitive impairment due to Alzheimer's disease for therapeutic interventions. (2025/01/01) ♡
• PLB2(Tau) mice are impaired in novel and temporal object recognition and show corresponding traits in brain MRI. (2025/01/01) ♡
• Rivastigmine interferes with the pharmacological activity of hydromethylthionine on presynaptic proteins in the line 66 model of frontotemporal dementia. (2025/01/01) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. A Biomarker-chip Assay in Preserved Red Blood Cells for the Diagnosis of Alzheimer's Disease (2025-12-29) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Safety, Tolerability and Pharmacokinetics of Multiple Ascending Doses of NIO752 in Progressive Supranuclear Palsy (2025-12-24) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Incremental Diagnostic Value of Tau-PET With [18F]RO948 vs Amyloid-PET in Patients With Cognitive Impairment (2025-12-23) ♡

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