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Sickle cell disease

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Search Period All yearsLast 12 monthsLast 5 years Topic All topicsGeneralNutrition and dietAlternative treatment methods Type of research Any type of researchHighest quality evidence only (77)Meta-analysis (14)Treatment guideline (2)Randomized trial (30)Systematic review (27)Phase 3 study (4)Clinical trial (631)Review article (208)Early study (phase 1 or 2) (15)Case report (141)Laboratory or animal research (19)Commentary or editorial (53)Retracted publication (2) Only studies currently recruiting participants (29)

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Publications and studies (2096)

• Early-stage study (phase 1 or 2)iEarly research in a small group, primarily aimed at safety and dosage. Whether it actually works still needs to be determined afterward. Escalating Doses of VAS-101 in Subjects With Stable Sickle Cell Disease (2026-08-05) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Investigating the Mechanistic Effects of Mitapivat in Subjects With Sickle Cell Disease (2026-08-04) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Effectiveness of a Computerized Tool (PAINRelieveIt) to Help Manage Pain Related to Sickle Cell Disease (2026-08-04) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Natural History of Sickle Cell Disease (2026-08-04) ♡
• Phase 3 studyiResearch in a large group of patients, the final step before a treatment can be approved. What comes out here carries significant weight. A Study to Investigate the Effect of Mitapivat on Transfusion Burden in Subjects With Sickle Cell Disease (SCD) (2026-08-04) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Genotype-Phenotype Correlation of PKLR Variants With Pyruvate Kinase, 2,3-Diphosphoglycerate and Adenosine Triphosphate Activities in Red Blood Cells of People With Sickle Cell Disease (2026-08-03) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. An mHealth Strategy to Improve Medication Adherence in Adolescents With Sickle Cell Disease (2026-07-31) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Integrative Medicine in Pain Management in Sickle Cell Disease (2026-07-31) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Integrative Medicine in Pain Management in Sickle Cell Disease, 2.0 (2026-07-31) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Acupressure in Patients With Sickle Cell Disease (2026-07-31) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. The Longitudinal Relationship of HU Adherence to HRQOL, Barriers to Adherence and Habit in SCD. (2026-07-31) ♡
• Early-stage study (phase 1 or 2)iEarly research in a small group, primarily aimed at safety and dosage. Whether it actually works still needs to be determined afterward. A Phase 1b, Open-Label Study of DISC-3405 in Participants With Sickle Cell Disease (SCD) (2026-07-30) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Blood Collection for Research Related to Certain Diseases Involving Blood Vessels (2026-07-30) ♡
• Early-stage study (phase 1 or 2)iEarly research in a small group, primarily aimed at safety and dosage. Whether it actually works still needs to be determined afterward. TMLI and Alemtuzumab for Treatment of Sickle Cell Disease (2026-07-30) ♡
• Early-stage study (phase 1 or 2)iEarly research in a small group, primarily aimed at safety and dosage. Whether it actually works still needs to be determined afterward. Partial Stem Cell Transplant for Sickle Cell Disease From Matched Donors (2026-07-29) ♡
• Phase 3 studyiResearch in a large group of patients, the final step before a treatment can be approved. What comes out here carries significant weight. The Efficacy and Safety of Rilzabrutinib in Participants Aged 10 to 65 Years With Sickle Cell Disease (2026-07-29) ♡
• Early-stage study (phase 1 or 2)iEarly research in a small group, primarily aimed at safety and dosage. Whether it actually works still needs to be determined afterward. Arginine Therapy for the Treatment of Pain in Children With Sickle Cell Disease (2026-07-29) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Insights Into Microbiome and Environmental Contributions to Sickle Cell Disease and Leg Ulcers Study (INSIGHTS Study) (2026-07-28) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Blood Sampling for Research Related to Sickle Cell Disease (2026-07-28) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Hyperbaric Oxygen Therapy in Sickle Cell Pain (2026-07-28) ♡
• Early-stage study (phase 1 or 2)iEarly research in a small group, primarily aimed at safety and dosage. Whether it actually works still needs to be determined afterward. Long-term Follow-up (LTFU) of Patients Treated With Genome-edited Autologous Hematopoietic Stem and Progenitor Cells (HSPC) (2026-07-28) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Cooperative Assessment of Late Effects for SCD Curative Therapies (2026-07-27) ♡
• Early-stage study (phase 1 or 2)iEarly research in a small group, primarily aimed at safety and dosage. Whether it actually works still needs to be determined afterward. Myeloablative Conditioning, Prophylactic Defibrotide and Haplo AlloSCT for Patients With Sickle Cell Disease (2026-07-27) ♡
• Phase 3 studyiResearch in a large group of patients, the final step before a treatment can be approved. What comes out here carries significant weight. A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE) (2026-07-24) ♡
• Early-stage study (phase 1 or 2)iEarly research in a small group, primarily aimed at safety and dosage. Whether it actually works still needs to be determined afterward. Haploidentical Donor Hematopoietic Cell Transplant for Sickle Cell Disease (2026-07-23) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. CPAP for Hypoxemic Acute Chest Syndrome in Sickle Cell Disease (2026-07-23) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Universal Newborn Screening For Sickle Cell Disease In Mozambique (2026-07-22) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Objective Neurocognitive Assessment of Young Children With Sickle Cell Disease by Eye-Tracking (2026-07-22) ♡
• Early-stage study (phase 1 or 2)iEarly research in a small group, primarily aimed at safety and dosage. Whether it actually works still needs to be determined afterward. Research Study Investigating How Well NDec Works in People With Sickle Cell Disease (2026-07-22) ♡
• Early-stage study (phase 1 or 2)iEarly research in a small group, primarily aimed at safety and dosage. Whether it actually works still needs to be determined afterward. A Phase I/II Study of ITU512 in Healthy Participants and Patients With Sickle Cell Disease (2026-07-20) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Peer i-Coaching for Activated Self-Management Optimization in Adolescents and Young Adults With Chronic Conditions (2026-07-17) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Secondary Pulmonary Hypertension in Adults With Sickle Cell Anemia (2026-07-16) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Hematopoietic Stem Cell BCL11A Enhancer Gene Editing for Sickle Cell Disease (2026-07-16) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Optimizing Hydroxyurea Therapy in Children With Sickle Cell Anemia In Malaria Endemic Areas: The NOHARM Maximum Tolerated Dose (MTD) Study (2026-07-16) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Alendronate for Osteonecrosis in Adults With Sickle Cell Disease (2026-07-16) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Early Life Exposures Among Children With Sickle Cell Disease (2026-07-15) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Best Noninvasive Predictor of Renal Function in Assessing Adult Sickle Nephropathy (2026-07-14) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Tocilizumab for Acute Chest Syndrome (2026-07-14) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Lidocaine for Opioid Sparing in Vaso-occlusive Crisis of Sickle Cell Disease (2026-07-13) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Sickle Cell, Pain and Mediterranean Diet (2026-07-13) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic Disorders (2026-07-13) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Observational Study to Deeply Phenotype Major Organs in Sickle Cell Disease After Curative Therapies (2026-07-13) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Study of Two Doses of Crizanlizumab Versus Placebo in Adolescent and Adult Sickle Cell Disease Patients (2026-07-10) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Ph I/II Study of Allogeneic SCT for Clinically Aggressive Sickle Cell Disease (SCD) (2026-07-08) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Study of HLA-Haploidentical Stem Cell Transplantation to Treat Clinically Aggressive Sickle Cell Disease (2026-07-08) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Haploidentical Bone Marrow Transplantation in Sickle Cell Patients (BMTCTN1507) (2026-07-08) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Developing the Family Map: Looking at Communal Coping (2026-07-08) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. mAnaging siCkle CELl disEase Through incReased AdopTion of hydroxyurEa in Nigeria (2026-07-07) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Long-term Mitapivat Dosing in Subjects With Stable Sickle Cell Disease: An Extension of a Phase I Pilot Study of Mitapivat (2026-07-07) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Study to Evaluate the Safety and Tolerability of Escalating Doses of Fostamatinib in Subjects With Stable Sickle Cell Disease (2026-07-07) ♡

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