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Sickle cell disease

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Search Period All yearsLast 12 monthsLast 5 years Topic All topicsGeneralNutrition and dietAlternative treatment methods Type of research Any type of researchOnly the most robust evidence (78)Meta-analysis (14)Treatment guideline (2)Randomized trial (30)Systematic review (27)Phase 3 study (5)Clinical trial (630)Review article (208)Early study (phase 1 or 2) (15)Case report (141)Laboratory or animal research (19)Commentary or editorial (54)Retracted publication (2) Studies currently recruiting participants only (32)

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Publications and studies (2099)

• CRISPR-HAWK: Haplotype- and Variant-aware guide design toolkit for CRISPR-Cas. (2025/12/27) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Advances in Gene Therapy for Inherited Haemoglobinopathies. (2025/12/27) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Fulminant Pneumococcal Meningitis With Neurovascular Complications in an Adult With Sickle Cell Anemia: A Case Report. (2025/12/24) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Heterozygous ABCC6 mutation in a patient with sickle cell disease: Pseudoxanthoma elasticum or pseudoxanthoma elasticum-like phenotype? (2025/12/24) ♡
• Temporal analysis of sickle cell disease mortality in adults (1999-2020): insights from the CDC WONDER database. (2025/12/23) ♡
• Prevalence, predictors, and moderators of transfer in primary care. (2025/12/22) ♡
• Hydroxyurea utilization among individuals with sickle cell disease in Tennessee: a pooled analysis of claims data. (2025/12/19) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Biosensors for Detection of Labile Heme in Biological Samples. (2025/12/19) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Monocellular and Multicellular Parasites Infesting Humans: A Review of Calcium Ion Mechanisms. (2025/12/19) ♡
• Assessing educational needs of sickle cell anemia healthcare providers in sub-Saharan Africa and the Caribbean. (2025/12/18) ♡
• Commentary or editorialiAn expert's opinion or commentary, not new research. Novel Compounds for Treating Hemoglobinopathies, Namely, Anemia, Sickle Cell Disease, or Thalassemia. (2025/12/18) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Behçet's disease and avascular necrosis of the knees: a case report. (2025/12/18) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Self-Management Interventions in Young Adults (18-30 Years) With Type 1 Diabetes, Sickle Cell Disease, and Inflammatory Bowel Disease: A Scoping Review. (2025/12/17) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Therapeutic applications of CRISPR-Cas9 gene editing. (2025/12/16) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Stroke risk assessment in children with sickle cell disease using transcranial Doppler ultrasound in Cameroon. (2025/12/16) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Gene Therapy of Beta Hemoglobinopathies. (2025/12/15) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. Acute Soft Head Syndrome: A Case Report in Kuwait and a Clinical Framework for Management. (2025/12/14) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Methodology for the Pediatric Dose Optimization for Seizures in Emergency Medical Services (PediDOSE) study. (2025/12/13) ♡
• Simplified Assessment of Erectile Dysfunction in Adult Men With Sickle Cell Disease: A Cross-Sectional Validation Study. (2025/12/12) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Molecular mastery: Harnessing DNA technology for disease prevention. (2025/12/11) ♡
• Hydroxycarbamide and Sickle Cell Anemia: Paradoxical Effects Related to Redox Mechanisms of Cellular Adaptation. (2025/12/09) ♡
• A 36-Year-Old Black Male With Sickle Cell Disease and Coexisting Psychiatric Comorbidity: Utilizing Open Dialogue Practices to Overcome Stigma and Enhance Patient-Centered Care. (2025/12/09) ♡
• Clinical trialiResearch in patients, without randomization between groups. Useful, but less certain than a randomized trial. Chronic Pediatric Diseases in Remote Villages of French Guiana Over a 9-Year Period. (2025/12/09) ♡
• Description of individual patientsiThe story of one or a couple of patients. Informative, but you cannot infer from it whether something works in general. SMARCB1-Deficient Renal Medullary Carcinoma: A Case Report Highlighting the Value of History and Race Information. (2025/12/05) ♡
• You only work with what you know: Healthcare providers' experiences using non-pharmacological interventions in managing sickle cell crisis pain in adolescents. (2025/12/01) ♡
• Randomized researchiParticipants were divided into groups by lottery and compared with each other. This reduces the chance that a difference is due to something other than the treatment. Nurse-Performed Bladder Ultrasound Effect on Pediatric Bladder Catheterization Success. (2025/12/01) ♡
• Randomized researchiParticipants were divided into groups by lottery and compared with each other. This reduces the chance that a difference is due to something other than the treatment. Including malnourished siblings in treatment improves nutritional outcomes for children with sickle cell anemia in Northern Nigeria: Results from a feasibility trial. (2025/12/01) ♡
• Purine Nucleoside Phosphorylase Inhibition Rebalances Purine Metabolism and Attenuates Organ Damage in Sickle Cell Mice. (2025/12/01) ♡
• Validation of a Pediatric Cognitive Assessment Tool to Advance Knowledge on Children's Cognitive Development, Health Risk Factors, and Health-promoting Interventions in Sub-Saharan Regions. (2025/12/01) ♡
• Exploring the quality of life of caregivers of children with sickle cell disease in a secondary health facility in Ghana. (2025/12/01) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Exploring the latest emerging drugs for the treatment of sickle cell disease. (2025/12/01) ♡
• Neurocognitive functioning of patients with sickle cell disease in low- and middle-income countries. (2025/12/01) ♡
• A novel transdermal curcumin gel shows potential in improving cardiac bioenergetic functions in Berkeley sickle cell mice. (2025/11/26) ♡
• Heme Modulates Bladder Contractility Through the HO-CO-sGC-cGMP Pathway: Insights into Sickle Cell Disease-Associated Bladder Dysfunction. (2025/11/25) ♡
• Review articleiA summary of what is known about a topic, written by experts. Not compiled according to fixed search rules, so the selection of studies may be biased. Innovative hematological strategies to combat maternal and child mortality in Africa: focus on anemia and sickle cell disease. (2025/11/18) ♡
• Echocardiographic and platelet markers of cardiovascular strain in sickle cell disease with superimposed preeclampsia: a perspective. (2025/11/17) ♡
• Systematic reviewiAll research on one question is searched according to fixed rules and compared side by side, so that no studies with poor outcomes are missed. Genetic patterns & public health implications of sickle cell anaemia across populations: A systematic review. (2025/11/01) ♡
• AI-assisted diagnosis of anemia through peripheral smear image analysis: A cross-validation study. (2025/10/31) ♡
• Elevated VWF with normal ADAMTS13 in pediatric sickle cell disease: links to crises and ischemic stroke. (2025/10/28) ♡
• Efficacy of traditional medicine in the management of sickle cell disease: a scoping review of current evidence. (2025/10/28) ♡
• Equipping Persons with Sickle Cell Disease, Transforming Care: A Protocol Paper on Feasibility and Acceptability of Self-Management Package in the Tribal Communities of Southern India. (2025/10/27) ♡
• Addressing anaemia in adivasi women of reproductive age: urgent policy imperatives for Karnataka. (2025/10/24) ♡
• Sustained expression of hemopexin in an animal model of sickle cell anemia. (2025/10/22) ♡
• A rare case of pediatric autoimmune pancreatitis and autoimmune hepatitis in a patient with sickle cell disease. (2025/10/21) ♡
• Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023. (2025/10/18) ♡
• Global age-sex-specific all-cause mortality and life expectancy estimates for 204 countries and territories and 660 subnational locations, 1950-2023: a demographic analysis for the Global Burden of Disease Study 2023. (2025/10/18) ♡
• Global burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023. (2025/10/18) ♡
• The small-molecule Syk inhibitor R788 inhibits hematopoiesis and worsens anemia in sickle cell disease mice. (2025/10/16) ♡
• The global, regional, and national burden of cancer, 1990-2023, with forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2023. (2025/10/11) ♡
• The role of hemoglobin F in sickle cell disease complications: a descriptive secondary analysis. (2025/10/09) ♡

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